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All Key Events

Showing 326 to 350 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

651	Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
652	Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
653	Decreased testosterone by the fetal Leydig cells, Increased corticosterone Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	66: Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis
654	Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	66: Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis
655	Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	4 AOPs 66: Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis 67: Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis 68: Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome 74: Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
656	Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) Short Name Decreased COUP-TFII in Leydig cells	1	Cellular	Nov 29, 2016	Dec 3, 2024	5 AOPs 66: Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis 67: Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis 68: Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome 526: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis 527: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased
657	Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells Short Name	2	Organ	Nov 29, 2016	Dec 3, 2016	2 AOPs 66: Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis 68: Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome
658	Decreased testosterone by the fetal Leydig cells, Increased estradiol Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	67: Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis
659	Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	67: Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis
660	decreased testosterone by fetal Leydig cells, Dysgenesis of fetal Leydig cells Short Name	2	Organ	Nov 29, 2016	Sep 16, 2017	67: Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis
661	Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	68: Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome
662	Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	74: Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
663	Desensitization, Nicotinic acetylcholine receptor Short Name	2	Molecular	Nov 29, 2016	Jun 7, 2018	3 AOPs 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2
664	Overwhelmed, Mitochondrial DNA repair mechanisms Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
667	Binding at picrotoxin site, iGABAR chloride channel Short Name	3	Molecular	Nov 29, 2016	Apr 29, 2019	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
669	Reduction, Neuronal synaptic inhibition Short Name Reduction, Neuronal synaptic inhibition	1	Cellular	Nov 29, 2016	May 16, 2018	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
671	Reduced, Prostaglandin F2alpha concentration, plasma Short Name	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
672	Reduced, Prostaglandin F2alpha synthesis, ovary Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
673	Reduced, Spawning behavior Short Name Reduced, Spawning behavior	1	Individual	Nov 29, 2016	Dec 3, 2016	100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
674	Reduced, Ability to attract spawning mates Short Name	1	Individual	Nov 29, 2016	Dec 3, 2016	2 AOPs 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
675	Reduced, Reproductive Success Short Name Reduced, Reproductive Success	2	Individual	Nov 29, 2016	Dec 3, 2016	5 AOPs 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior 101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release 63: Cyclooxygenase inhibition leading to reproductive dysfunction 102: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with meiotic prophase I /metaphase I transition 103: Cyclooxygenase inhibition leading to reproductive dysfunction via interference with spindle assembly checkpoint
678	Reduced, Pheromone release Short Name Reduced, Pheromone release	1	Individual	Nov 29, 2016	Dec 3, 2016	101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
679	Decline, Population trajectory Short Name Decline, Population trajectory	1	Population	Nov 29, 2016	Dec 3, 2016	309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
681	Decreased, Prostaglandin F2alpha synthesis, ovary Short Name	1	Organ	Nov 29, 2016	Sep 16, 2017	101: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of pheromone release
682	Generation, Amplified excitatory postsynaptic potential (EPSP) Short Name	1	Cellular	Nov 29, 2016	May 18, 2018	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain