AOP-Wiki

API

All Key Events

Showing 1126 to 1150 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1262	Apoptosis Short Name Apoptosis	1	Cellular	Feb 7, 2017	May 31, 2025	21 AOPs 205: AOP from chemical insult to cell death 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans 212: Histone deacetylase inhibition leading to testicular atrophy 285: Inhibition of N-linked glycosylation leads to liver injury 419: Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway 439: Activation of the AhR leading to metastatic breast cancer 452: Adverse outcome pathway of PM-induced respiratory toxicity 393: AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 502: Decrease, cholesterol synthesis leads to orofacial clefting 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation 535: Binding and activation of GPER leading to learning and memory impairments 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production 563: Aryl hydrocarbon Receptor (AHR) activation causes Premature Ovarian Insufficiency via Bax mediated apoptosis 595: Emerging OPFRS reproductive outcome pathway 616: organic UV filter and its Photoproducts reproductive toxicity pathways 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis 322: Alkylation of DNA leading to decreased sperm count
1260	Direct mitochondrial inhibition Short Name Direct mitochondrial inhibition	1	Molecular	Feb 7, 2017	Sep 16, 2017	205: AOP from chemical insult to cell death
1259	narcosis Short Name narcosis	1	Cellular	Feb 7, 2017	Sep 16, 2017	205: AOP from chemical insult to cell death
1258	Decompartmentalization Short Name Decompartmentalization	1	Cellular	Feb 7, 2017	Sep 16, 2017	205: AOP from chemical insult to cell death
1257	Induced parturition Short Name Induced parturition	0	Individual	Jan 13, 2017	Jan 13, 2017	2 AOPs 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
1256	increased mantel display Short Name increased mantel display	0	Organ	Jan 13, 2017	Jan 13, 2017	2 AOPs 203: 5-hydroxytryptamine transporter inhibition leading to decreased reproductive success and population decline 204: 5-hydroxytryptamine transporter inhibition leading to increased reproductive success and population increase
1255	induced spawning Short Name induced spawning	1	Individual	Jan 13, 2017	Jan 13, 2017	195: 5-hydroxytryptamine transporter (5-HTT) inhibition leading to population increase
1254	Infant leukaemia Short Name IFL	0	Individual	Dec 16, 2016	Aug 1, 2022	202: Inhibitor binding to topoisomerase II leading to infant leukaemia
1253	MLL chromosomal translocation Short Name MLL translocation	1	Cellular	Dec 16, 2016	Aug 1, 2022	202: Inhibitor binding to topoisomerase II leading to infant leukaemia
1252	Binding to (interferes with) topoisomerase II enzyme Short Name Binding, topoisomerase II	1	Molecular	Dec 16, 2016	Aug 1, 2022	202: Inhibitor binding to topoisomerase II leading to infant leukaemia
1251	Chronic, Mucus hypersecretion Short Name Chronic, Mucus hypersecretion	1	Tissue	Nov 29, 2016	Aug 25, 2021	None
1250	Decrease, Lung function Short Name Decreased lung function	1	Individual	Nov 29, 2016	Sep 8, 2021	7 AOPs 148: EGFR Activation Leading to Decreased Lung Function 302: Lung surfactant function inhibition leading to decreased lung function 411: Oxidative stress Leading to Decreased Lung Function 418: Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway 419: Aryl hydrocarbon receptor activation leading to impaired lung function through P53 toxicity pathway 424: Oxidative stress Leading to Decreased Lung Function via CFTR dysfunction 425: Oxidative Stress Leading to Decreased Lung Function via Decreased FOXJ1
1248	EGFR , Activation Short Name EGFR , Activation	0		Nov 29, 2016	Nov 29, 2016	None
1247	EGFR , PPAR-alpha activation Short Name EGFR , PPAR-alpha activation	0		Nov 29, 2016	Nov 29, 2016	None
1246	Lung function, Decrease Short Name Lung function, Decrease	0		Nov 29, 2016	Nov 29, 2016	None
1245	Mucus , Hypersecretion Short Name Mucus , Hypersecretion	0		Nov 29, 2016	Nov 29, 2016	None
1244	Mucus hypersecretion, Short Name Mucus hypersecretion,	0		Nov 29, 2016	Nov 29, 2016	None
1243	Altered, Ca2+-calmodulin activated signal transduction Short Name	3	Cellular	Nov 29, 2016	Jun 7, 2018	4 AOPs 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
1242	Increased, Second Messenger Production Short Name Increased, Second Messenger Production	1	Cellular	Nov 29, 2016	Sep 16, 2017	200: Estrogen receptor activation leading to breast cancer
1241	Increased, Motility Short Name Increased, Motility	1	Cellular	Nov 29, 2016	Feb 28, 2024	2 AOPs 200: Estrogen receptor activation leading to breast cancer 439: Activation of the AhR leading to metastatic breast cancer
1240	Altered, Protein Production Short Name Altered, Protein Production	1	Cellular	Nov 29, 2016	Sep 16, 2017	200: Estrogen receptor activation leading to breast cancer
1239	Altered, Gene Expression Short Name Altered, Gene Expression	1	Molecular	Nov 29, 2016	Mar 6, 2019	3 AOPs 200: Estrogen receptor activation leading to breast cancer 275: Histone deacetylase inhibition leads to neural tube defects 533: Retinoic acid receptor antagonism during neurodevelopment leading to impaired learning and memory
1238	Activation of oxidative stress pathway Short Name Oxidation	3	Molecular	Nov 29, 2016	Jun 19, 2017	594: Micro plastic effect on reproduction
1237	Sensitization, Immune system Short Name Sensitization, Immune system	1	Individual	Nov 29, 2016	Dec 3, 2016	None
1236	Generation of novel epitopes , Antigen presentation Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	None