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All Key Events

Showing 876 to 900 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1326	Increased, 5-HT3 (5-hydroxytryptamine) Short Name Increased, 5-HT3	0	Molecular	Apr 13, 2017	Jun 1, 2017	214: Network of SSRIs (selective serotonin reuptake inhibitors)
1327	Decreased, seizure Short Name Decreased, seizure	0	Individual	Apr 13, 2017	Apr 13, 2017	None
1328	Inactivated, 5-HTR (serotonin receptors) Short Name Inactivated, 5-HTR	0	Molecular	Apr 13, 2017	May 31, 2017	5 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 225: Serotonin transporter activation to agitation 224: Serotonin transporter activation to depression
1329	Reduce expression, BDNF (Brain-derived neurotrophic factor) Short Name Reduce expression, BDNF	0	Molecular	Apr 13, 2017	May 31, 2017	5 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 225: Serotonin transporter activation to agitation 224: Serotonin transporter activation to depression
1330	Decreased, neuroplasticity Short Name Decreased, neuroplasticity	0	Molecular	Apr 13, 2017	Nov 10, 2025	6 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 225: Serotonin transporter activation to agitation 224: Serotonin transporter activation to depression 604: Binding of Alpha 1-Adrenergics to Antagonists Leading to Depression
1331	Inhibit, agitation Short Name Inhibit, agitation	0	Individual	Apr 13, 2017	Apr 13, 2017	None
1332	Inhibit, depression Short Name Inhibit, depression	0	Individual	Apr 13, 2017	Apr 13, 2017	None
1333	Increase, mental stress Short Name Increase, mental stress	0	Individual	Apr 13, 2017	Apr 13, 2017	None
1334	Increase, cortisone Short Name Increase, cortisone	0	Molecular	Apr 13, 2017	Apr 13, 2017	214: Network of SSRIs (selective serotonin reuptake inhibitors)
1335	Reduced, BDNF (Brain-derived neurotrophic factor) Short Name Reduced, BDNF	0	Molecular	Apr 13, 2017	Nov 10, 2025	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 604: Binding of Alpha 1-Adrenergics to Antagonists Leading to Depression
1336	Activation, 5-HT2A (Serotonin 2A) Short Name Activation, 5-HT2A	0	Molecular	Apr 13, 2017	Apr 13, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1337	Activate, PLC (Phospholipase C) Short Name Activate, PLC	0	Molecular	Apr 13, 2017	Apr 13, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1338	Increase, inositol triphosphate Short Name Increase, inositol triphosphate	0	Molecular	Apr 13, 2017	Apr 13, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1339	Increase, intracellular calcium Short Name Increase, intracellular calcium	1	Cellular	Apr 13, 2017	Jul 21, 2023	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
1340	Activate, calmodulin Short Name Activate, calmodulin	0	Molecular	Apr 13, 2017	Apr 13, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1341	Increase, myosin light chain phosphorylation Short Name	0	Molecular	Apr 13, 2017	Apr 13, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1342	Increase, vascular smooth muscle contraction Short Name	0	Molecular	Apr 13, 2017	Apr 13, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1343	Increase, hypertension Short Name Increase, hypertension	0	Individual	Apr 13, 2017	Apr 13, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1344	Increased, seizure Short Name Increased, seizure	0	Individual	Apr 13, 2017	Jun 1, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 223: Serotonin transporter activation to seizure 230: presynaptic neuron 1 activation to epilepsy 231: presynaptic neuron 2 repression to epilepsy
1345	Increased, agitation Short Name Increased, agitation	0	Molecular	Apr 13, 2017	Jun 1, 2017	3 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 222: Mental stress to agitation 225: Serotonin transporter activation to agitation
1346	Increased, depression Short Name Increased, depression	0	Individual	Apr 13, 2017	Feb 6, 2026	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 224: Serotonin transporter activation to depression 604: Binding of Alpha 1-Adrenergics to Antagonists Leading to Depression
1347	Decreased, extracellular serotonin Short Name Decreased, extracellular serotonin	0	Molecular	Apr 14, 2017	May 31, 2017	7 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1348	Increase, seizure Short Name Increase, seizure	0	Individual	Apr 14, 2017	Apr 14, 2017	3 AOPs 215: Molecular events lead to epilepsy 402: Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain 471: Neuron defect induced early behavioral change
1349	Activated, presynaptic neuron 1 Short Name Activated, presynaptic neuron 1	0	Molecular	Apr 14, 2017	Jun 2, 2017	3 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 471: Neuron defect induced early behavioral change
1350	Increased, glutamate Short Name Increased, glutamate	1	Molecular	Apr 14, 2017	Oct 11, 2021	4 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms