Key Event Relationships (KERs)

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Showing 2601 to 2625 of 3081 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1556 1417: NFE2/Nrf2 repression 1419: Reduced, FXR activity Jun 2, 2017 Jun 2, 2017
2984 1417: NFE2/Nrf2 repression 2162: Activation, HIF1α Aug 20, 2023 Aug 20, 2023
3035 1417: NFE2/Nrf2 repression 2009: Activation, inflammation pathway Aug 28, 2023 Aug 28, 2023
3276 1417: NFE2/Nrf2 repression 1392: Increase, Oxidative Stress Jul 4, 2024 Jul 4, 2024
3685 1417: NFE2/Nrf2 repression 2386: Lipid-peroxidation overload Nov 4, 2025 Nov 4, 2025 None
3712 1417: NFE2/Nrf2 repression 1445: Increase, LPO Jan 19, 2026 Jan 19, 2026
2414 1895: inflammasome activity, increased 1868: Hyperinflammation Jun 25, 2021 Jun 25, 2021
2667 2007: Non-coding RNA expression，alteration 2009: Activation, inflammation pathway Jun 17, 2022 Jun 17, 2022
2668 2007: Non-coding RNA expression，alteration 1392: Increase, Oxidative Stress Jun 17, 2022 Jun 17, 2022
2670 2007: Non-coding RNA expression，alteration 2012: Fibroblast proliferation and differentiation Jun 17, 2022 Jun 17, 2022
2671 2007: Non-coding RNA expression，alteration 1262: Apoptosis Jun 17, 2022 Jun 17, 2022
2672 2007: Non-coding RNA expression，alteration 1945: Dysfunctional autophagy Jun 17, 2022 Jun 17, 2022
3203 2007: Non-coding RNA expression，alteration 1457: EMT May 1, 2024 May 1, 2024
1287 1235: Non-neuronal production of IL-8/CXCL1, Epithelial irritation 1218: Opening of calcium channel, Calcium influx Nov 29, 2016 Dec 3, 2016 None
1277 1224: Non-neuronal production of TNF, Epithelial irritation 1225: Leukocyte infiltration Nov 29, 2016 Dec 3, 2016 None
1288 1224: Non-neuronal production of TNF, Epithelial irritation 1218: Opening of calcium channel, Calcium influx Nov 29, 2016 Dec 3, 2016 None
884 862: Not Increased, Circulating Ketone Bodies 863: Increased, Catabolism of Muscle Protein Nov 29, 2016 Jun 11, 2018
1640 1466: Notochord malformation 1005: Reduced, Swimming performance Aug 3, 2017 Aug 3, 2017
630 616: Occurrence, A paroxysmal depolarizing shift 613: Occurrence, Epileptic seizure Nov 29, 2016 May 22, 2018
853 835: Occurrence, Ballooning degeneration (hepatocyte) 838: Induction, Microvesicular fat Nov 29, 2016 Dec 3, 2016
854 835: Occurrence, Ballooning degeneration (hepatocyte) 839: Formation, Mallory body Nov 29, 2016 Dec 3, 2016
1141 1106: Occurrence, cardiac arrhythmia 351: Increased Mortality Nov 29, 2016 Dec 3, 2016
2854 1106: Occurrence, cardiac arrhythmia 1919: Increased，Cardiac dysfunction Jan 29, 2023 Jan 29, 2023 None
1136 1100: Occurrence, cardiac arrthymia 351: Increased Mortality Nov 29, 2016 Dec 3, 2016 None
821 823: Occurrence, Cystic dilatation (renal tubule) 819: Decreased, Glomerular filtration Nov 29, 2016 Dec 3, 2016