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Showing 2876 to 2900 of 3119 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1558	1420: Reduced, SHP activity	1421: Activated, LXR	Jun 2, 2017	Jun 2, 2017	1 AOP 232: NFE2/Nrf2 repression to steatosis
673	673: Reduced, Spawning behavior	674: Reduced, Ability to attract spawning mates	Nov 29, 2016	Dec 3, 2016	1 AOP 100: Cyclooxygenase inhibition leading to reproductive dysfunction via inhibition of female spawning behavior
1641	1005: Reduced, Swimming performance	1467: Growth, reduction	Aug 3, 2017	Aug 3, 2017	1 AOP 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
1642	1005: Reduced, Swimming performance	636: Decreased, survival	Aug 3, 2017	Aug 3, 2017	1 AOP 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
2081	1005: Reduced, Swimming performance	360: Decrease, Population growth rate	Apr 21, 2020	Jun 4, 2020	1 AOP 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration
2212	1005: Reduced, Swimming performance	351: Increased Mortality	Nov 30, 2020	Sep 8, 2021	5 AOPs 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
3674	1005: Reduced, Swimming performance	2382: Increase, nerve spasm	Oct 20, 2025	Oct 20, 2025	1 AOP 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
587	586: Reduced, swimming speed	587: Reduced, feeding 1	Nov 29, 2016	Dec 3, 2016	2 AOPs 91: Sodium channel inhibition leading to reduced survival 95: Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival
588	586: Reduced, swimming speed	588: Increased, predation	Nov 29, 2016	Dec 3, 2016	3 AOPs 91: Sodium channel inhibition leading to reduced survival 95: Ether-a-go-go (ERG) voltage-gated potassium channel inhibition leading to reduced survival 93: sodium channel inhibition leading to increased predation
1895	1631: Reduction fo Pigmentation pattern	360: Decrease, Population growth rate	May 3, 2019	May 3, 2019	1 AOP 292: Inhibition of tyrosinase leads to decreased population in fish
1893	1629: Reduction in melanin level	1630: Reduction of melanosome level	May 3, 2019	May 3, 2019	1 AOP 292: Inhibition of tyrosinase leads to decreased population in fish
396	408: reduction in ovarian granulosa cells, Aromatase (Cyp19a1)	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	Nov 29, 2016	Nov 29, 2016	1 AOP 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female
1638	1464: Reduction of collagen crosslinking	1465: Weak collagen matrix	Aug 3, 2017	Aug 3, 2017	1 AOP 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
1892	1628: Reduction of L-Dopaquinone	1629: Reduction in melanin level	May 3, 2019	May 3, 2019	1 AOP 292: Inhibition of tyrosinase leads to decreased population in fish
1894	1630: Reduction of melanosome level	1631: Reduction fo Pigmentation pattern	May 3, 2019	May 3, 2019	1 AOP 292: Inhibition of tyrosinase leads to decreased population in fish
5	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	219: Reduction, Plasma 17beta-estradiol concentrations	Nov 29, 2016	Mar 20, 2017	6 AOPs 7: Aromatase (Cyp19a1) reduction leading to impaired fertility in adult female 25: Aromatase inhibition leading to reproductive dysfunction 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish) 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription 310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
3326	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	285: Reduction, Vitellogenin synthesis in liver	Jul 26, 2024	Jul 26, 2024	1 AOP 540: Oxidative Stress in the Fish Ovary Leads to Reproductive Impairment via Reduced Vitellogenin Production
3624	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	1696: Decrease of egg production and cummulative fecundity	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
2145	1789: Reduction, E2 Synthesis by the undifferentiated gonad	1790: Increased, Differentiation to Testis	Jun 15, 2020	Jul 11, 2022	1 AOP 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
3229	1611: Reduction, androstenedione	1690: Decrease, circulating testosterone levels	May 24, 2024	Apr 8, 2025	1 AOP 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
36	28: Reduction, Angiogenesis	110: Impairment, Endothelial network	Nov 29, 2016	Jan 18, 2022	1 AOP 43: Disruption of VEGFR Signaling Leading to Developmental Defects
3683	28: Reduction, Angiogenesis	2383: Increase, Hemopericardium	Oct 30, 2025	Oct 30, 2025	1 AOP 614: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced vascular endothelial growth factor
59	49: Reduction, Ca and HCO3 transport to shell gland	106: Reduction, Eggshell thickness	Nov 29, 2016	Dec 3, 2016	1 AOP 28: Cyclooxygenase inhibition leading reproductive failure
438	447: Reduction, Cholesterol transport in mitochondria	413: Reduction, Testosterone synthesis in Leydig cells	Nov 29, 2016	Dec 2, 2016	2 AOPs 18: PPARα activation in utero leading to impaired fertility in males 51: PPARα activation leading to impaired fertility in adult male rodents
3517	447: Reduction, Cholesterol transport in mitochondria	2319: Decreased, Pregnenolone levels	Apr 8, 2025	Apr 8, 2025	None

Key Event Relationships (KERs)

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