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All KERs

Showing 751 to 775 of 3164 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1345	1265: Decrease, Ftz-f1 expression	988: Decrease, Circulating ETH	Feb 9, 2017	Feb 9, 2017	1 AOP 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1
2722	2040: Decrease, GLI1/2 target gene expression	1821: Decrease, Cell proliferation	Jul 28, 2022	Nov 17, 2022	None
2723	2040: Decrease, GLI1/2 target gene expression	1365: Increase, Apoptosis	Jul 28, 2022	Jul 28, 2022	None
2731	2040: Decrease, GLI1/2 target gene expression	2043: Decrease, SHH second messenger production	Aug 23, 2022	Apr 3, 2025	2 AOPs 460: Antagonism of Smoothened receptor leading to orofacial clefting 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting
2805	2040: Decrease, GLI1/2 target gene expression	2041: Decrease, facial prominence outgrowth	Nov 17, 2022	Nov 17, 2022	None
2882	2040: Decrease, GLI1/2 target gene expression	1262: Apoptosis	Apr 6, 2023	Apr 4, 2025	1 AOP 460: Antagonism of Smoothened receptor leading to orofacial clefting
2721	2028: Decrease, GLI1/2 translocation	2040: Decrease, GLI1/2 target gene expression	Jul 28, 2022	Apr 2, 2025	1 AOP 460: Antagonism of Smoothened receptor leading to orofacial clefting
2102	1773: Decrease, Global DNA methylation	1774: Increase, Casp transcription	Apr 30, 2020	Apr 30, 2020	2 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2)
2110	1773: Decrease, Global DNA methylation	1778: Decrease, Heritable DNA methylation (F3)	Apr 30, 2020	Apr 30, 2020	2 AOPs 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
2795	2071: Decrease, Glucose pool	1821: Decrease, Cell proliferation	Nov 1, 2022	Nov 1, 2022	1 AOP 267: Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion
2530	1951: Decrease, Glucose uptake	1952: Abnormal, Glucose homeostasis	Nov 18, 2021	Nov 18, 2021	1 AOP 431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
2529	1949: Decrease, GLUT4	1951: Decrease, Glucose uptake	Nov 18, 2021	Nov 18, 2021	1 AOP 431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
1668	1476: Decrease, Glycolysis	1477: OXPHOS, decreased	Oct 10, 2017	Oct 10, 2017	1 AOP 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
1738	1476: Decrease, Glycolysis	40: Mitochondrial ATP production, decreased	May 24, 2018	May 24, 2018	None
2169	1521: Decrease, Growth	360: Decrease, Population growth rate	Oct 8, 2020	Oct 8, 2020	1 AOP 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
2804	1521: Decrease, Growth	1141: Decreased, Reproductive Success	Nov 16, 2022	Nov 16, 2022	1 AOP 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin
2111	1778: Decrease, Heritable DNA methylation (F3)	1779: Increase, Casp transcription (F3)	Apr 30, 2020	Apr 30, 2020	2 AOPs 340: DNA methyltransferase inhibition leading to transgenerational effects (1) 341: DNA methyltransferase inhibition leading to transgenerational effects (2)
649	633: Decrease, histaminergic neuron excitation	634: N/A, sedation	Nov 29, 2016	Dec 3, 2016	1 AOP 99: Histamine (H2) receptor antagonism leading to reduced survival
1643	633: Decrease, histaminergic neuron excitation	341: Impairment, Learning and memory	Aug 11, 2017	Aug 11, 2017	1 AOP 99: Histamine (H2) receptor antagonism leading to reduced survival
791	788: Decrease, Incorporation of active iodide into iodotyrosines	771: Decrease, Serum thyroid hormone (T4/T3)	Nov 29, 2016	Dec 3, 2016	None
886	867: Decrease, Intracellular pH	768: Increase, Cytotoxicity	Nov 29, 2016	Nov 29, 2016	1 AOP 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
3448	2298: Decrease, intratesticular testosterone	1690: Decrease, circulating testosterone levels	Dec 12, 2024	Mar 20, 2026	3 AOPs 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring
3449	2298: Decrease, intratesticular testosterone	1688: AGD, decreased	Dec 12, 2024	May 6, 2025	1 AOP 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
3487	2298: Decrease, intratesticular testosterone	1786: nipple retention, increased	Jan 30, 2025	Mar 20, 2026	1 AOP 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring
3488	2298: Decrease, intratesticular testosterone	2082: Hypospadias	Feb 15, 2025	Apr 7, 2026	1 AOP 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring

Key Event Relationships (KERs)

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