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Showing 2426 to 2450 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

552	424: Inhibition, Na+/I- symporter (NIS)	277: TH synthesis, Decreased	Nov 29, 2016	Dec 3, 2016	2 AOPs 65: XX Inhibition of Sodium Iodide Symporter and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse)
1503	424: Inhibition, Na+/I- symporter (NIS)	341: Impairment, Learning and memory	May 10, 2017	Apr 4, 2019	1 AOP 54: Inhibition of Na+/I- symporter (NIS) leads to learning and memory impairment
2232	424: Inhibition, Na+/I- symporter (NIS)	281: T4 in serum, Decreased	Dec 9, 2020	Nov 19, 2025	1 AOP 176: Sodium Iodide Symporter (NIS) Inhibition leading to altered amphibian metamorphosis
934	887: Inhibition, NADH-ubiquinone oxidoreductase (complex I)	177: Increase, Mitochondrial dysfunction	Nov 29, 2016	Oct 3, 2025	1 AOP 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
1809	887: Inhibition, NADH-ubiquinone oxidoreductase (complex I)	1477: OXPHOS, decreased	Dec 20, 2018	Dec 20, 2018	1 AOP 276: Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome
1940	887: Inhibition, NADH-ubiquinone oxidoreductase (complex I)	1545: Decrease in mitochondrial oxidative phosphorylation	Jun 7, 2019	Jun 7, 2019	1 AOP 273: Mitochondrial complex inhibition leading to liver injury
213	195: Inhibition, NMDARs	52: Decreased, Calcium influx	Nov 29, 2016	Apr 7, 2018	2 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
214	195: Inhibition, NMDARs	341: Impairment, Learning and memory	Nov 29, 2016	Dec 3, 2016	None
215	195: Inhibition, NMDARs	191: Neuronal dysfunction	Nov 29, 2016	Dec 3, 2016	None
3124	195: Inhibition, NMDARs	2208: Aberrant, synaptic formation and plasticity	Jan 25, 2024	Jan 25, 2024	1 AOP 522: Estrogen antagonism leading to increased risk of autism-like behavior
387	202: Inhibition, Nuclear factor kappa B (NF-kB)	152: Suppression, Inflammatory cytokines	Nov 29, 2016	Dec 3, 2016	1 AOP 14: Glucocorticoid Receptor Activation Leading to Increased Disease Susceptibility
1828	202: Inhibition, Nuclear factor kappa B (NF-kB)	1575: Activation, Caspase 8 pathway	Jan 7, 2019	Mar 7, 2019	1 AOP 278: IKK complex inhibition leading to liver injury
1871	202: Inhibition, Nuclear factor kappa B (NF-kB)	986: Impairment of TDAR	Mar 12, 2019	Mar 12, 2019	None
1921	202: Inhibition, Nuclear factor kappa B (NF-kB)	1569: Impaired T cell activation	May 23, 2019	Jun 25, 2019	None
2003	202: Inhibition, Nuclear factor kappa B (NF-kB)	1702: Suppression of T cell activation	Nov 17, 2019	Mar 2, 2023	1 AOP 277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
2306	202: Inhibition, Nuclear factor kappa B (NF-kB)	1496: Increased proinflammatory mediators	Mar 30, 2021	Mar 30, 2021	None
2644	202: Inhibition, Nuclear factor kappa B (NF-kB)	1633: Increase in inflammation	Apr 8, 2022	Apr 8, 2022	1 AOP 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
3698	202: Inhibition, Nuclear factor kappa B (NF-kB)	2394: Lower survival B lymphocytes	Dec 3, 2025	Dec 3, 2025	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
3699	202: Inhibition, Nuclear factor kappa B (NF-kB)	2395: Diminished proliferation of activated B lymphocytes	Dec 3, 2025	Dec 3, 2025	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
3700	202: Inhibition, Nuclear factor kappa B (NF-kB)	2396: Diminished differentiation of activated B lymphocytes	Dec 3, 2025	Dec 3, 2025	1 AOP 618: PPARgamma activation leads to a diminished vaccine response
1131	877: Inhibition, organic anion transporter 1 (OAT1)	1096: Increased, blood uric acid concentration	Nov 29, 2016	Dec 3, 2016	1 AOP 138: Organic anion transporter (OAT1) inhibition leading to renal failure and mortality
3652	2376: Inhibition, OATP1C1	2093: Decreased brain T4/T3	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
1202	1155: Inhibition, Pendrin	277: TH synthesis, Decreased	Nov 29, 2016	Dec 3, 2016	1 AOP 192: Pendrin inhibition leading to altered amphibian metamorphosis
836	828: Inhibition, Phospholipase A	829: Damage, Lipid bilayer	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
837	828: Inhibition, Phospholipase A	831: Disturbance, Lysosomal function	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity

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