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Showing 3101 to 3125 of 3164 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

472	327: Accumulation, Fatty acid	291: Accumulation, Triglyceride	Nov 29, 2016	May 28, 2024	1 AOP 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
514	327: Accumulation, Fatty acid	454: Increased, Triglyceride formation	Nov 29, 2016	Dec 3, 2016	1 AOP 58: NR1I3 (CAR) suppression leading to hepatic steatosis
515	327: Accumulation, Fatty acid	459: Increase, Liver steatosis	Nov 29, 2016	Dec 3, 2016	4 AOPs 58: NR1I3 (CAR) suppression leading to hepatic steatosis 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis 57: AhR activation leading to hepatic steatosis
662	570: Accumulation, Damaged mitochondrial DNA	571: Accelerated, Aging	Nov 29, 2016	Dec 3, 2016	1 AOP 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
2503	1942: Accumulation, Toxic Tau oligomers	1582: Impaired axonial transport	Oct 26, 2021	Oct 26, 2021	1 AOP 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
2507	1942: Accumulation, Toxic Tau oligomers	188: Neuroinflammation	Oct 26, 2021	Oct 26, 2021	1 AOP 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
1865	1605: Accumulation, misfolded proteins	1512: Unfolded Protein Response	Mar 6, 2019	Mar 6, 2019	1 AOP 285: Inhibition of N-linked glycosylation leads to liver injury
3045	1605: Accumulation, misfolded proteins	2017: Endoplasmic reticulum stress	Sep 14, 2023	Sep 14, 2023	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
3046	1605: Accumulation, misfolded proteins	2188: Caspase activation	Sep 14, 2023	Sep 14, 2023	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
663	571: Accelerated, Aging	572: Decrease, Number of worker bees	Nov 29, 2016	Dec 3, 2016	1 AOP 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
1844	1591: Absorption of photon energy	1593: Radical generation	Feb 4, 2019	Feb 4, 2019	None
3299	2242: Dendritic spine abnormality	341: Impairment, Learning and memory	Jul 14, 2024	Jul 14, 2024	None
3301	2242: Dendritic spine abnormality	1944: Dysfunctional synapses	Jul 17, 2024	Apr 3, 2025	1 AOP 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
565	564: Abnormal, Roll change within caste	565: Reduced, Brood care	Nov 29, 2016	Dec 3, 2016	3 AOPs 82: Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
579	564: Abnormal, Roll change within caste	561: Reduced, Food storage	Nov 29, 2016	Dec 3, 2016	1 AOP 86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
580	564: Abnormal, Roll change within caste	572: Decrease, Number of worker bees	Nov 29, 2016	Dec 3, 2016	None
1149	564: Abnormal, Roll change within caste	1107: Weakened, Colony	Nov 29, 2016	Dec 3, 2016	None
1151	1108: Abnormal, Role change within caste	1107: Weakened, Colony	Nov 29, 2016	Dec 3, 2016	3 AOPs 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 184: Nosema infection causes abnormal role change that leads to colony loss/failure
2408	1891: abnormal, placental labyrinth vasculature morphology	1892: increase, placental insufficiency	May 31, 2021	May 31, 2021	1 AOP 151: AhR activation leading to preeclampsia
196	183: Abnormal, Morphogenesis	342: Increased, Lethality	Nov 29, 2016	Dec 3, 2016	None
197	183: Abnormal, Morphogenesis	366: Increased, Structural malformations	Nov 29, 2016	Dec 3, 2016	None
1025	183: Abnormal, Morphogenesis	1001: Increased, Developmental Defects	Nov 29, 2016	Dec 3, 2016	None
2531	1952: Abnormal, Glucose homeostasis	1953: GDM	Nov 18, 2021	Nov 18, 2021	1 AOP 431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
569	560: Abnormal, Foraging activity and behavior	572: Decrease, Number of worker bees	Nov 29, 2016	Dec 3, 2016	2 AOPs 81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure 85: Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
584	560: Abnormal, Foraging activity and behavior	561: Reduced, Food storage	Nov 29, 2016	Dec 3, 2016	None

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