Key Event Relationships (KERs)

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Showing 276 to 300 of 3081 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1418 1310: Activation, PI3K 1299: Activation, AKT Apr 13, 2017 Apr 13, 2017 None
1419 1310: Activation, PI3K 1302: Activation, L-FABP Apr 13, 2017 Apr 13, 2017 None
1420 1310: Activation, PI3K 1309: Activation, aPKC Apr 13, 2017 Apr 13, 2017 None
369 227: Activation, PPARα 266: Decrease, Steroidogenic acute regulatory protein (STAR) Nov 29, 2016 Dec 2, 2016
370 227: Activation, PPARα 289: Decrease, Translocator protein (TSPO) Nov 29, 2016 Dec 2, 2016
535 227: Activation, PPARα 483: Activation, LXR alpha Nov 29, 2016 Dec 3, 2016
1229 227: Activation, PPARα 1170: Increase, Phenotypic enzyme activity Nov 29, 2016 Dec 31, 2020
1233 227: Activation, PPARα 1175: Increase, Genes involved in fatty acid oxidation Nov 29, 2016 Dec 3, 2016 None
1236 227: Activation, PPARα 1174: Activation, NADPH Oxidase Nov 29, 2016 Dec 3, 2016 None
1410 227: Activation, PPARα 1303: Activation, HSD17B4 Apr 12, 2017 Apr 12, 2017 None
2073 227: Activation, PPARα 807: Decreased, cholesterol Apr 6, 2020 May 1, 2020
2134 227: Activation, PPARα 1756: Decreased, 11KT May 11, 2020 May 11, 2020 None
2252 227: Activation, PPARα 716: Increase, cell proliferation (hepatocytes) Dec 31, 2020 Dec 31, 2020
2253 227: Activation, PPARα 719: Increase, hepatocellular adenomas and carcinomas Dec 31, 2020 Dec 31, 2020
3675 227: Activation, PPARα 1312: Increase, Fatty acid β-oxidation Oct 30, 2025 Oct 30, 2025
3681 227: Activation, PPARα 948: reduced production, VEGF Oct 30, 2025 Oct 30, 2025
340 380: Activation, Pre-MIE: Metabolism of AFB1 373: Formation, Pro-mutagenic DNA Adducts Nov 29, 2016 Dec 3, 2016 None
2482 239: Activation, Pregnane-X receptor, NR1l2 295: Induction, Upregulation of glucuronyltransferase activity Sep 14, 2021 Sep 14, 2021
3100 239: Activation, Pregnane-X receptor, NR1l2 54: Up Regulation, CD36 Nov 30, 2023 Mar 27, 2024
3365 239: Activation, Pregnane-X receptor, NR1l2 2268: Decreased, INSIG1 protein activity Oct 22, 2024 Feb 10, 2025
1480 1369: Activation, PTGS-1 1375: Increase, platelet aggregation Apr 17, 2017 Apr 17, 2017
1481 1369: Activation, PTGS-1 1374: Increase, mucosal blood flow Apr 17, 2017 Apr 17, 2017
1482 1369: Activation, PTGS-1 1373: Increase, mucous Apr 17, 2017 Apr 17, 2017
1483 1369: Activation, PTGS-1 1372: Increase, bicarbonate Apr 17, 2017 Apr 17, 2017
1478 1370: Activation, PTGS-2 1377: Decrease, leukocyte adherence Apr 17, 2017 Apr 17, 2017