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All KERs

Showing 426 to 450 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2374	1877: Altered, retinal layer structure	1643: Altered, Visual function	May 11, 2021	Jul 8, 2022	1 AOP 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
2244	1829: Altered, TH-dependent gene expression	1101: Altered, Amphibian metamorphosis	Dec 9, 2020	Dec 9, 2020	1 AOP 191: Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis
316	286: Altered, Transcription of genes by the AR	240: Feminisation or incomplete development, Primary and accessory male sex organs	Nov 29, 2016	Dec 3, 2016	1 AOP 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
317	286: Altered, Transcription of genes by the AR	310: Alteration, Wnt pathway	Nov 29, 2016	Dec 3, 2016	1 AOP 19: Androgen receptor antagonism leading to adverse effects in the male foetus (mammals)
2127	286: Altered, Transcription of genes by the AR	1688: AGD, decreased	May 11, 2020	Feb 4, 2026	3 AOPs 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
2132	286: Altered, Transcription of genes by the AR	1786: nipple retention, increased	May 11, 2020	May 11, 2020	None
2273	286: Altered, Transcription of genes by the AR	1800: Reduced granulosa cell proliferation	Jan 28, 2021	Mar 18, 2025	1 AOP 345: Androgen receptor (AR) antagonism leading to decreased fertility in females
2909	286: Altered, Transcription of genes by the AR	2134: Increase, AR protein expression/abundance	May 11, 2023	May 11, 2023	1 AOP 495: Androgen receptor activation leading to prostate cancer
1919	1643: Altered, Visual function	361: Decline, Population	May 22, 2019	May 22, 2019	None
2143	1643: Altered, Visual function	360: Decrease, Population growth rate	May 25, 2020	May 25, 2020	1 AOP 297: Inhibition of retinaldehyde dehydrogenase leads to population decline
2375	1643: Altered, Visual function	351: Increased Mortality	May 11, 2021	Jul 8, 2022	4 AOPs 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning
3192	2108: Altered, white brain matter	341: Impairment, Learning and memory	Apr 12, 2024	Apr 12, 2024	2 AOPs 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
3667	2108: Altered, white brain matter	2231: Impaired locomotor function	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
1970	1673: Alveolar collapse	1674: Alveolar reopening	Jul 3, 2019	Jul 3, 2019	None
1974	1673: Alveolar collapse	1677: Reduced tidal volume	Jul 3, 2019	Jul 3, 2019	1 AOP 302: Lung surfactant function inhibition leading to decreased lung function
2284	1673: Alveolar collapse	1498: Loss of alveolar capillary membrane integrity	Feb 16, 2021	Feb 1, 2022	1 AOP 302: Lung surfactant function inhibition leading to decreased lung function
2285	1673: Alveolar collapse	1833: Impaired lung function	Feb 16, 2021	Feb 16, 2021	None
2371	1673: Alveolar collapse	1250: Decreased lung function	Apr 27, 2021	Apr 27, 2021	1 AOP 302: Lung surfactant function inhibition leading to decreased lung function
1971	1674: Alveolar reopening	1675: Loss of barrier function	Jul 3, 2019	Jul 3, 2019	None
2173	1674: Alveolar reopening	1498: Loss of alveolar capillary membrane integrity	Oct 22, 2020	Oct 22, 2020	None
3379	2274: Androgen receptor activation, increased	286: Altered, Transcription of genes by the AR	Nov 2, 2024	Nov 24, 2024	None
3628	2274: Androgen receptor activation, increased	2365: AGD, increased	Sep 5, 2025	Sep 5, 2025	1 AOP 547: Androgen receptor agonism leading to long anogenital distance in female offspring
3706	2393: AR transcriptional activity in GT tissues, reduced	2399: FGF10/FGFR2-IIIb signaling in genital tissue, reduced	Dec 16, 2025	Dec 16, 2025	1 AOP 619: Androgen receptor antagonism leads to delayed preputial seperation via reduced fibroblast growth factor in genital-tubercle tissues
2983	2160: Angiogenesis disfunction	2161: Increase, Vascular disrupting effects	Aug 19, 2023	Aug 19, 2023	None
3032	2181: Angiogenesis dysfunction	2161: Increase, Vascular disrupting effects	Aug 28, 2023	Aug 28, 2023	5 AOPs 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 510: Demethylation of PPAR promotor leading to vascular disrupting effects 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway 508: Nrf2 inhibition leading to vascular disrupting effects through activating HIF1α, Semaphorin 6A, and Dll4-Notch pathway

Key Event Relationships (KERs)

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