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Showing 751 to 775 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

886	867: Decrease, Intracellular pH	768: Increase, Cytotoxicity	Nov 29, 2016	Nov 29, 2016	1 AOP 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors
3448	2298: Decrease, intratesticular testosterone	1690: Decrease, circulating testosterone levels	Dec 12, 2024	May 7, 2025	3 AOPs 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring
3449	2298: Decrease, intratesticular testosterone	1688: AGD, decreased	Dec 12, 2024	May 6, 2025	1 AOP 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring
3487	2298: Decrease, intratesticular testosterone	1786: nipple retention, increased	Jan 30, 2025	Sep 17, 2025	1 AOP 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring
3488	2298: Decrease, intratesticular testosterone	2082: Hypospadias	Feb 15, 2025	Sep 18, 2025	1 AOP 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring
2753	2059: Decrease, knickkopf gene	2060: Decrease, Chitin laminar organization	Aug 28, 2022	Aug 28, 2022	1 AOP 467: Knickkopf leading to mortality
2754	2059: Decrease, knickkopf gene	2061: Decrease, Prevent chitin degradation by chitinases	Aug 28, 2022	Aug 28, 2022	1 AOP 467: Knickkopf leading to mortality
1671	1478: Decrease, Leaf cell mitosis	1479: Decrease, Leaf development	Oct 10, 2017	Oct 10, 2017	1 AOP 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
1672	1479: Decrease, Leaf development	1480: Increase, Growth hormone	Oct 10, 2017	Oct 10, 2017	None
2283	1479: Decrease, Leaf development	1521: Decrease, Growth	Feb 16, 2021	Feb 16, 2021	1 AOP 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
2335	1479: Decrease, Leaf development	1863: Decrease, Reproduction	Apr 11, 2021	Apr 11, 2021	1 AOP 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
1666	1474: Decrease, Light harvest capacity	1475: Decrease, Photosynthesis	Oct 10, 2017	Oct 10, 2017	1 AOP 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
3061	2198: Decrease, mbp	352: N/A, Neurodegeneration	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
3643	2375: Decrease, Mis-timed EcR-responsive NR cascade	988: Decrease, Circulating ETH	Sep 29, 2025	Sep 29, 2025	1 AOP 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
3644	2375: Decrease, Mis-timed EcR-responsive NR cascade	1522: Inhibition, CHS-1	Sep 29, 2025	Sep 29, 2025	1 AOP 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
2094	1770: Decrease, MMP	1477: OXPHOS, decreased	Apr 30, 2020	Apr 30, 2020	2 AOPs 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 328: Excessive reactive oxygen species production leading to mortality (2)
2347	1770: Decrease, MMP	1864: Increase, Programmed cell death	Apr 11, 2021	Apr 11, 2021	None
3163	1770: Decrease, MMP	177: Increase, Mitochondrial dysfunction	Mar 14, 2024	Mar 14, 2024	1 AOP 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways
3613	1770: Decrease, MMP	40: Mitochondrial ATP production, decreased	Sep 2, 2025	Sep 2, 2025	1 AOP 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction
3657	2377: neural network formation	2231: Impaired locomotor function	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
3659	2377: neural network formation	341: Impairment, Learning and memory	Oct 8, 2025	Oct 8, 2025	1 AOP 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
2758	2063: Decrease, New cuticle secretion	990: Increase, Incomplete ecdysis	Aug 28, 2022	Aug 28, 2022	1 AOP 467: Knickkopf leading to mortality
559	572: Decrease, Number of worker bees	563: Death/Failure, Colony	Nov 29, 2016	Dec 3, 2016	2 AOPs 81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure 85: Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
573	572: Decrease, Number of worker bees	568: impaired, Hive thermoregulation	Nov 29, 2016	Dec 3, 2016	2 AOPs 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
1470	1366: Decrease, Oogenesis	488: Decrease, Ovulation	Apr 15, 2017	Apr 15, 2017	None

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