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Showing 851 to 875 of 3119 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1617	1451: decreased reward	1450: decreased dopamine	Jul 24, 2017	Jul 24, 2017	1 AOP 72: Epigenetic modification of PPARG leading to adipogenesis
2611	1981: Decrease,SIRT1(sirtuin 1) levels	1172: Increased activation, Nuclear factor kappa B (NF-kB)	Mar 22, 2022	Aug 27, 2023	1 AOP 443: DNA damage and mutations leading to Metastatic Breast Cancer
1650	520: Decreased sperm quantity or quality in the adult, Decreased fertility	406: decreased, Fertility	Aug 11, 2017	Aug 11, 2017	1 AOP 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
3619	520: Decreased sperm quantity or quality in the adult, Decreased fertility	1863: Decrease, Reproduction	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
2161	1798: Decreased spermatogenesis	406: decreased, Fertility	Jul 13, 2020	Jul 13, 2020	2 AOPs 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2388	1798: Decreased spermatogenesis	1696: Decrease of egg production and cummulative fecundity	May 12, 2021	May 12, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2620	1798: Decreased spermatogenesis	328: Decrease, Fecundity	Mar 28, 2022	Mar 28, 2022	1 AOP 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2623	1798: Decreased spermatogenesis	1863: Decrease, Reproduction	Mar 28, 2022	Mar 28, 2022	1 AOP 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2624	1798: Decreased spermatogenesis	360: Decrease, Population growth rate	Mar 28, 2022	Mar 28, 2022	1 AOP 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2076	1756: Decreased, 11KT	1758: Impaired, Spermatogenesis	Apr 16, 2020	Apr 19, 2021	2 AOPs 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
2165	1756: Decreased, 11KT	330: Decrease, Fertility	Jul 21, 2020	Jul 21, 2020	None
2166	1756: Decreased, 11KT	1798: Decreased spermatogenesis	Jul 21, 2020	Jul 21, 2020	1 AOP 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory
3518	2320: Decreased, 17βHSD3 activity	1690: Decrease, circulating testosterone levels	Apr 8, 2025	Apr 8, 2025	None
9	8: Decreased, 3-hydroxyacyl-CoA dehydrogenase type-2 activity	179: Decrease, Fatty acid β-oxidation	Nov 29, 2016	Dec 3, 2016	1 AOP 36: Peroxisomal Fatty Acid Beta-Oxidation Inhibition Leading to Steatosis
1530	1401: Decreased, 5-HT3	1344: Increased, seizure	Jun 1, 2017	Jun 1, 2017	1 AOP 223: Serotonin transporter activation to seizure
2401	1880: Decreased, ALDH1A activity	1881: Decreased, atRA concentration	May 24, 2021	Dec 18, 2024	2 AOPs 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
2477	1881: Decreased, atRA concentration	1882: Disrupted, meiotic initiation in oocyte	Sep 10, 2021	Jul 4, 2025	None
2561	1881: Decreased, atRA concentration	1682: Disruption, Progenitor cells of second heart field	Feb 8, 2022	Feb 15, 2022	1 AOP 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
3776	1881: Decreased, atRA concentration	2419: Decreased, RAR activation	Apr 24, 2026	Apr 24, 2026	1 AOP 398: Decreased ALDH1A (RALDH) activity leading to decreased fertility via disrupted meiotic initiation of fetal oogonia
2630	1987: Decreased , Androgen and Progestin	1988: Decreased, Maturation Inducing Steroids Surge by Granulosa cells	Apr 5, 2022	Apr 5, 2022	1 AOP 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
1542	1409: Decreased, angiogenesis	1385: Activated, gastric ulcer formation	Jun 2, 2017	Jun 2, 2017	1 AOP 228: NSAID induced PTGS2 inactivation to gastric ulcer
645	627: Decreased, anxiety	629: Decreased, sheltering	Nov 29, 2016	Dec 3, 2016	1 AOP 98: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to decreased shelter seeking and increased predation
1248	1183: Decreased, Apoptosis (Epithelial Cells)	1192: Increased, Ductal Hyperplasia	Nov 29, 2016	Dec 3, 2016	1 AOP 200: Estrogen receptor activation leading to breast cancer
2914	1183: Decreased, Apoptosis (Epithelial Cells)	854: Alterations, Cellular proliferation / hyperplasia	May 11, 2023	May 11, 2023	1 AOP 495: Androgen receptor activation leading to prostate cancer
801	800: Decreased, Aromatase (Cyp19a1) mRNA	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	Nov 29, 2016	Dec 3, 2016	2 AOPs 122: Prolyl hydroxylase inhibition leading to reproductive dysfunction via increased HIF1 heterodimer formation 123: Unknown MIE leading to reproductive dysfunction via increased HIF-1alpha transcription

Key Event Relationships (KERs)

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