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All KERs

Showing 1126 to 1150 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1775	1539: Endocytosis	898: Disruption, Lysosome	Nov 12, 2018	Nov 12, 2018	2 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption
1106	1068: Endometrial squamous metaplasia, Increase	1069: Increased, Hyperplasia (glandular epithelial cells of endometrium)	Nov 29, 2016	Dec 3, 2016	None
3607	1068: Endometrial squamous metaplasia, Increase	772: Increase, Hyperplasia (glandular epithelial cells of endometrium)	Aug 26, 2025	Aug 26, 2025	None
3610	1068: Endometrial squamous metaplasia, Increase	1070: Increased, adenosquamous carcinomas of endometrium	Aug 26, 2025	Sep 18, 2025	1 AOP 167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
2711	2017: Endoplasmic reticulum stress	1512: Unfolded Protein Response	Jul 25, 2022	Jul 25, 2022	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
2453	1913: Endothelial cell dysfunction	87: Release, Cytokine	Aug 4, 2021	Aug 4, 2021	1 AOP 412: Endothelial cell dysfunction leading to thromboinflammation
2511	1913: Endothelial cell dysfunction	1666: dysfunction of microcirculation	Oct 28, 2021	Oct 28, 2021	None
3170	2212: Epididymal agenesis	1758: Impaired, Spermatogenesis	Mar 20, 2024	Dec 3, 2024	1 AOP 526: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis
2970	2152: Epigenetic modification process	2153: Expression of factors ruling proliferation, modified	Jul 27, 2023	Mar 27, 2025	1 AOP 503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation
1627	1457: EMT	1273: Expression of Collagen	Jul 26, 2017	Jul 26, 2017	None
1655	1457: EMT	68: Increase, Collagen accumulation	Aug 16, 2017	Aug 16, 2017	1 AOP 241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
1725	1457: EMT	1276: Lung fibrosis	Mar 18, 2018	Mar 18, 2018	None
1779	1457: EMT	1275: Collagen Deposition	Nov 20, 2018	Nov 20, 2018	1 AOP 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis
1840	1457: EMT	1587: Fibroproliferative airway lesions	Jan 30, 2019	Jan 30, 2019	1 AOP 280: α-diketone-induced bronchiolitis obliterans
2154	1457: EMT	1458: Pulmonary fibrosis	Jul 9, 2020	Jul 9, 2020	1 AOP 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
2614	1457: EMT	1982: Metastasis, Breast Cancer	Mar 22, 2022	Sep 26, 2023	1 AOP 443: DNA damage and mutations leading to Metastatic Breast Cancer
3200	1457: EMT	1651: Resistant gastric cancer	Apr 23, 2024	Apr 23, 2024	1 AOP 298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
3204	1457: EMT	2013: Airway remodeling	May 1, 2024	May 1, 2024	1 AOP 452: Adverse outcome pathway of PM-induced respiratory toxicity
3306	1457: EMT	885: Increase, Cancer	Jul 18, 2024	Jul 18, 2024	1 AOP 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT
3391	2251: Increased E2 availability	1065: Activation, ERα	Nov 15, 2024	Nov 21, 2024	3 AOPs 504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol 565: 17β-Hydroxysteroid dehydrogenase 2, inhibition leading to activation, estrogen receptor alpha
2880	2126: ERa inactivation	2127: Increased adipocyte size	Apr 6, 2023	Apr 6, 2023	1 AOP 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2881	2126: ERa inactivation	2128: Increased adipocyte numbers	Apr 6, 2023	Apr 6, 2023	1 AOP 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2906	2126: ERa inactivation	2130: increased lipid accumulation	May 4, 2023	May 4, 2023	1 AOP 493: ERa inactivation alters AT expansion and functions and leads to insulin resistance and metabolically unhealthy obesity
2929	2126: ERa inactivation	179: Decrease, Fatty acid β-oxidation	May 25, 2023	May 25, 2023	1 AOP 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome
2930	2126: ERa inactivation	1115: Increase, ROS	May 25, 2023	May 25, 2023	1 AOP 497: ERa inactivation alters mitochondrial functions and insulin signalling in skeletal muscle and leads to insulin resistance and metabolic syndrome

Key Event Relationships (KERs)

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