Prototypical Stressors

Showing 476 to 500 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

502	Low LET Radiation		None
334	low molecular weight proteins		257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
374	LPS		None
575	Lysodren, Mitotan, Mitotane	Lysodren, Mitotan, Mitotane, CAS-RN: 164203-73-0, DTXSID30425146	349: Inhibition of 11β-hydroxylase leading to decresed population trajectory
245	Makisterone A		4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1
546	Malathion	Malathion, CAS-RN: 121-75-5, DTXSID4020791	2 AOPs 551: Increased Muscarinic M2 Receptor leading to Arrhythmia 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
606	Malonoben	Malonoben, CAS-RN: 10537-47-0, DTXSID1042106	None
314	Mancozeb	Mancozeb, CAS-RN: 8018-01-7, DTXSID0034695	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
33	Maneb	Maneb, CAS-RN: 12427-38-2, DTXSID9020794	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
721	Manganese	Manganese, CAS-RN: 7439-96-5, DTXSID2024169	2 AOPs 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
263	Meclofenamic acid	Meclofenamic acid, CAS-RN: 644-62-2, DTXSID0048559	152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
679	Meconium		None
189	Mefenamic acid	Mefenamic acid, CAS-RN: 61-68-7, DTXSID5023243	None
192	Meloxicam	Meloxicam, CAS-RN: 71125-38-7, DTXSID1020803	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
271	Mental stress		403: combined unhealthy lifestyle factors leading to metabolic syndrome
58	Mercaptobenzole		None
34	Mercaptobenzothiazole	2-Mercaptobenzothiazole, CAS-RN: 149-30-4, DTXSID1020807	2 AOPs 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
35	Mercuric chloride	Mercuric chloride, CAS-RN: 7487-94-7, DTXSID5020811	2 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
36	Mercury	Mercury, CAS-RN: 7439-97-6, DTXSID1024172	3 AOPs 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) 556: Decreased Na/K ATPase activity leading to heart failure 558: Phosphodiesterase inhibition leading to heart failure
381	Mercury chloride	Mercury chloride, CAS-RN: 51312-24-4, DTXSID40858724	None
422	Metformin	Metformin, CAS-RN: 657-24-9, DTXSID2023270	None
37	Methimazole	Methimazole, CAS-RN: 60-56-0, DTXSID4020820	5 AOPs 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
537	Methotrexate	Methotrexate, CAS-RN: 59-05-2, DTXSID4020822	None
340	Methoxyacetic acid	Methoxyacetic acid, CAS-RN: 625-45-6, DTXSID1031591	212: Histone deacetylase inhibition leading to testicular atrophy
828	Methoxychlor	Methoxychlor, CAS-RN: 72-43-5, DTXSID9020827	561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol