Prototypical Stressors

Showing 476 to 500 of 853 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

58	Mercaptobenzole		None
34	Mercaptobenzothiazole	2-Mercaptobenzothiazole, CAS-RN: 149-30-4, DTXSID1020807	2 AOPs 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
35	Mercuric chloride	Mercuric chloride, CAS-RN: 7487-94-7, DTXSID5020811	2 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
36	Mercury	Mercury, CAS-RN: 7439-97-6, DTXSID1024172	3 AOPs 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) 556: Decreased Na/K ATPase activity leading to heart failure 558: Phosphodiesterase inhibition leading to heart failure
381	Mercury chloride	Mercury chloride, CAS-RN: 51312-24-4, DTXSID40858724	None
422	Metformin	Metformin, CAS-RN: 657-24-9, DTXSID2023270	None
37	Methimazole	Methimazole, CAS-RN: 60-56-0, DTXSID4020820	5 AOPs 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
537	Methotrexate	Methotrexate, CAS-RN: 59-05-2, DTXSID4020822	None
340	Methoxyacetic acid	Methoxyacetic acid, CAS-RN: 625-45-6, DTXSID1031591	212: Histone deacetylase inhibition leading to testicular atrophy
828	Methoxychlor	Methoxychlor, CAS-RN: 72-43-5, DTXSID9020827	561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
238	Methoxyfenozide	Methoxyfenozide, CAS-RN: 161050-58-4, DTXSID3032628	2 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
353	Methoxyflurane	Methoxyflurane, CAS-RN: 76-38-0, DTXSID7025556	260: CYP2E1 activation and formation of protein adducts leading to neurodegeneration
38	Methyl methanesulfonate	Methyl methanesulfonate, CAS-RN: 66-27-3, DTXSID7020845	None
650	Methyl parathion	Methyl parathion, CAS-RN: 298-00-0, DTXSID1020855	3 AOPs 405: Organo-Phosphate Chemicals induced inhibition of AChE leading to impaired cognitive function 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality 561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
39	Methyl-l-N'-nitro-N-nitroguanidine	Methylnitronitrosoguanidine, CAS-RN: 70-25-7, DTXSID2020846	None
359	Methylcarbino		None
639	Methyldihydrotestosterone		376: Androgen receptor agonism leading to male-biased sex ratio
40	Methylmercuric(II) chloride	Methylmercuric(II) chloride, CAS-RN: 115-09-3, DTXSID5020813	17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
218	metofluthrin	Metofluthrin, CAS-RN: 240494-70-6, DTXSID4034738	107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat
830	Metolachlor	Metolachlor, CAS-RN: 51218-45-2, DTXSID4022448	561: Aromatase induction leading to estrogen receptor alpha activation via increased estradiol
855	Metribuzin	Metribuzin, CAS-RN: 21087-64-9, DTXSID6024204	567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
574	Metyrapone	Metyrapone, CAS-RN: 54-36-4, DTXSID1023314	349: Inhibition of 11β-hydroxylase leading to decresed population trajectory
289	Miconazole	Miconazole, CAS-RN: 22916-47-8, DTXSID6023319	None
799	Milrinone		2 AOPs 554: β-adrenergic receptor agonists leading to arrhythmias. 558: Phosphodiesterase inhibition leading to heart failure
486	minocycline	Minocycline, CAS-RN: 10118-90-8, DTXSID1045033	277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response