Prototypical Stressors

Showing 476 to 500 of 874 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

551	Losartan	Losartan, CAS-RN: 114798-26-4, DTXSID7023227	319: Binding to ACE2 leading to lung fibrosis
779	lotenone		475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
502	Low LET Radiation		None
334	low molecular weight proteins		257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
374	LPS		None
575	Lysodren, Mitotan, Mitotane	Lysodren, Mitotan, Mitotane, CAS-RN: 164203-73-0, DTXSID30425146	349: Inhibition of 11β-hydroxylase leading to decresed population trajectory
245	Makisterone A		4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1
546	Malathion	Malathion, CAS-RN: 121-75-5, DTXSID4020791	2 AOPs 551: Increased Muscarinic M2 Receptor leading to Arrhythmia 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
606	Malonoben	Malonoben, CAS-RN: 10537-47-0, DTXSID1042106	None
314	Mancozeb	Mancozeb, CAS-RN: 8018-01-7, DTXSID0034695	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
33	Maneb	Maneb, CAS-RN: 12427-38-2, DTXSID9020794	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
721	Manganese	Manganese, CAS-RN: 7439-96-5, DTXSID2024169	2 AOPs 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
263	Meclofenamic acid	Meclofenamic acid, CAS-RN: 644-62-2, DTXSID0048559	152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
679	Meconium		None
189	Mefenamic acid	Mefenamic acid, CAS-RN: 61-68-7, DTXSID5023243	None
192	Meloxicam	Meloxicam, CAS-RN: 71125-38-7, DTXSID1020803	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
271	Mental stress		403: combined unhealthy lifestyle factors leading to metabolic syndrome
58	Mercaptobenzole		None
34	Mercaptobenzothiazole	2-Mercaptobenzothiazole, CAS-RN: 149-30-4, DTXSID1020807	2 AOPs 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
35	Mercuric chloride	Mercuric chloride, CAS-RN: 7487-94-7, DTXSID5020811	2 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
36	Mercury	Mercury, CAS-RN: 7439-97-6, DTXSID1024172	3 AOPs 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) 556: Decreased Na/K ATPase activity leading to heart failure 558: Phosphodiesterase inhibition leading to heart failure
381	Mercury chloride	Mercury chloride, CAS-RN: 51312-24-4, DTXSID40858724	None
422	Metformin	Metformin, CAS-RN: 657-24-9, DTXSID2023270	None
37	Methimazole	Methimazole, CAS-RN: 60-56-0, DTXSID4020820	5 AOPs 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
537	Methotrexate	Methotrexate, CAS-RN: 59-05-2, DTXSID4020822	None