Prototypical Stressors

Showing 376 to 400 of 855 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

36	Mercury	Mercury, CAS-RN: 7439-97-6, DTXSID1024172	3 AOPs 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) 556: Decreased Na/K ATPase activity leading to heart failure 558: Phosphodiesterase inhibition leading to heart failure
35	Mercuric chloride	Mercuric chloride, CAS-RN: 7487-94-7, DTXSID5020811	2 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress
34	Mercaptobenzothiazole	2-Mercaptobenzothiazole, CAS-RN: 149-30-4, DTXSID1020807	2 AOPs 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
58	Mercaptobenzole		None
271	Mental stress		403: combined unhealthy lifestyle factors leading to metabolic syndrome
192	Meloxicam	Meloxicam, CAS-RN: 71125-38-7, DTXSID1020803	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
189	Mefenamic acid	Mefenamic acid, CAS-RN: 61-68-7, DTXSID5023243	None
679	Meconium		None
263	Meclofenamic acid	Meclofenamic acid, CAS-RN: 644-62-2, DTXSID0048559	152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
721	Manganese	Manganese, CAS-RN: 7439-96-5, DTXSID2024169	2 AOPs 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
33	Maneb	Maneb, CAS-RN: 12427-38-2, DTXSID9020794	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
314	Mancozeb	Mancozeb, CAS-RN: 8018-01-7, DTXSID0034695	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
606	Malonoben	Malonoben, CAS-RN: 10537-47-0, DTXSID1042106	None
546	Malathion	Malathion, CAS-RN: 121-75-5, DTXSID4020791	2 AOPs 551: Increased Muscarinic M2 Receptor leading to Arrhythmia 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
245	Makisterone A		4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1
575	Lysodren, Mitotan, Mitotane	Lysodren, Mitotan, Mitotane, CAS-RN: 164203-73-0, DTXSID30425146	349: Inhibition of 11β-hydroxylase leading to decresed population trajectory
374	LPS		None
334	low molecular weight proteins		257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
502	Low LET Radiation		None
779	lotenone		475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
551	Losartan	Losartan, CAS-RN: 114798-26-4, DTXSID7023227	319: Binding to ACE2 leading to lung fibrosis
376	Lipopolysaccharride	Lipopolysaccharride, CAS-RN: NOCAS, DTXSID4036695	237: Substance interaction with lung resident cell membrane components leading to atherosclerosis
564	Linuron	Linuron, CAS-RN: 330-55-2, DTXSID2024163	None
112	Lindane	Lindane, CAS-RN: 58-89-9, DTXSID2020686	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
415	Light (290-700 nm)		282: Adverse outcome pathway on photochemical toxicity initiated by light exposure