AOPs

OECD View API
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Showing 1 to 25 of 589 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
651 Suppression, Estrogen receptor (ER) activity leads to Impaired, Spermatogenesis via epigenetic modifications John Frisch BY-SA 1046: Suppression, Estrogen receptor (ER) activity 1758: Impaired, Spermatogenesis
650 Polystyrene nanoplastic-induced PPAR signaling dysregulation leading to hepatic steatosis and metabolic dysfunction via oxidative stress-driven lipid metabolism reprogramming Ying Wang All rights reserved None None
649 Photocatalytic ROS generation by titanium dioxide nanoparticles leading to visual dysfunction and reduced larval survival via retinal photoreceptor oxidative damage Ying Wang All rights reserved None None
648 Nanomaterial-induced ferritinophagy activation leading to Parkinson's-like motor dysfunction via iron-dependent ferroptotic neurodegeneration Ying Wang All rights reserved None None
647 ROS formation leading to growth inhibition modulated by the Keap1–Nrf2 antioxidant response Ying Wang All rights reserved 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
646 Binding and activation of AhR/PPARγ lead to lipid metabolism disorders Shiheng Gui BY-SA 1995: Abnormal lipid metabolism
645 Binding and activation of AhR lead to cardiovascular aging Shiheng Gui BY-SA 2430: Aryl hydrocarbon receptor（AhR）activation 2438: Increase, Cardiovascular aging
644 Bulky DNA adducts leading to chromosomal aberrations and mutations Beckner Andersano BY-SA 1879: Bulky DNA adducts, increase
642 Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation Jung-Hwa Oh BY-SA 2421: Inhibition, Intestinal FXR 1489: Increase, Steatohepatitis
641 Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2418: Increased, phenotypic female-biased sex ratio
640 Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle John Frisch BY-SA 1065: Activation, estrogen receptor alpha 406: decreased, Fertility
639 Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2415: Precocious puberty
638 Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis Wei Mu BY-SA
637 Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2413: Increased, uterine weight
636 Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS) Shihori Tanabe All rights reserved 1115: Increase, Reactive oxygen species 2416: human amyotrophic lateral sclerosis (ALS)
635 Increased adrenal glucocorticoid production leading to MASLD progression (6) You Song BY-SA None None
634 Increased adrenal glucocorticoid production leading to MASLD progression (5) You Song BY-SA None None
633 Increased adrenal glucocorticoid production leading to MASLD progression (4) You Song BY-SA None None
632 Increased adrenal glucocorticoid production leading to MASLD progression (3) You Song BY-SA None None
631 Decreased thyroid hormone receptor beta transcriptional activity leading to MASLD progression via endoplasmic reticulum stress You Song BY-SA None None
630 Decreased 11β-Hydroxysteroid dehydrogenase type 2 activity leading to MASLD progression via insulin resistance-associated mitochondrial dysfunction You Song BY-SA 2409: Decrease, 11β-Hydroxysteroid dehydrogenase type 2 activity None Under Development
629 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
628 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
627 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development
626 Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress You Song BY-SA 2410: Increase, 11β-Hydroxysteroid dehydrogenase type 1 activity Under Development