AOPs

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Showing 1 to 25 of 595 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
657 Atrazine-induced photosystem II inhibition leading to yield loss in rice (Oryza sativa) SURIYA S BY-SA 2456: Photosystem II inhibition 2462: Yield loss in rice paddy ecosystems
656 Competitive inhibition of lactate dehydrogenase leading to impaired vascular development Yanhong Wei BY-SA None None
655 Activation of Transient Receptor Potential A1 (TRPA1) Leading to Pulmonary Fibrosis Yuan Luo All rights reserved 1215: TRPA1 activation, TRPA1 Receptor 1458: Pulmonary fibrosis
654 Oxidative stress leading to emphysema via apoptosis All rights reserved None None
653 Inhibition to Microsomal Triglyceride Transfer Protein Leads to Steatosis Huan Yang All rights reserved 2452: Inhibition to Microsomal Triglyceride Transfer Protein
652 Inhibition of brain insulin-degrading enzyme (IDE) leads to cognitive decline (adult) Barbara Viviani All rights reserved 2448: Brain insulin-degrading enzyme (IDE), inhibition 2450: Cognitive Decline
651 Suppression, Estrogen receptor (ER) activity leads to Impaired, Spermatogenesis via epigenetic modifications John Frisch BY-SA 1046: Suppression, Estrogen receptor (ER) activity 1758: Impaired, Spermatogenesis
650 Polystyrene nanoplastic-induced PPAR signaling dysregulation leading to hepatic steatosis and metabolic dysfunction via oxidative stress-driven lipid metabolism reprogramming Ying Wang All rights reserved None None
649 Photocatalytic ROS generation by titanium dioxide nanoparticles leading to visual dysfunction and reduced larval survival via retinal photoreceptor oxidative damage Ying Wang All rights reserved None None
648 Nanomaterial-induced ferritinophagy activation leading to Parkinson's-like motor dysfunction via iron-dependent ferroptotic neurodegeneration Ying Wang All rights reserved None None
647 ROS formation leading to growth inhibition modulated by the Keap1–Nrf2 antioxidant response Ying Wang All rights reserved 1115: Increase, Reactive oxygen species 1521: Decrease, Growth
646 Binding and activation of AhR/PPARγ lead to lipid metabolism disorders Shiheng Gui BY-SA 1995: Abnormal lipid metabolism
645 Binding and activation of AhR lead to cardiovascular aging Shiheng Gui BY-SA 2430: Aryl hydrocarbon receptor（AhR）activation 2438: Increase, Cardiovascular aging
644 Bulky DNA adducts leading to chromosomal aberrations and mutations Beckner Andersano BY-SA 1879: Bulky DNA adducts, increase
642 Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation Jung-Hwa Oh BY-SA 2421: Inhibition, Intestinal FXR 1489: Increase, Steatohepatitis
641 Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2418: Increased, phenotypic female-biased sex ratio
640 Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle John Frisch BY-SA 1065: Activation, estrogen receptor alpha 406: decreased, Fertility
639 Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2415: Precocious puberty
638 Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis Wei Mu BY-SA
637 Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2413: Increased, uterine weight
636 Increase in reactive oxygen species (ROS) leading to human amyotrophic lateral sclerosis (ALS) Shihori Tanabe All rights reserved 1115: Increase, Reactive oxygen species 2416: human amyotrophic lateral sclerosis (ALS)
635 Increased adrenal glucocorticoid production leading to MASLD progression (6) You Song BY-SA None None
634 Increased adrenal glucocorticoid production leading to MASLD progression (5) You Song BY-SA None None
633 Increased adrenal glucocorticoid production leading to MASLD progression (4) You Song BY-SA None None
632 Increased adrenal glucocorticoid production leading to MASLD progression (3) You Song BY-SA None None