AOPs

OECD View API
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Showing 1 to 10 of 10 Fulltext Results
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ID Title Point of Contact License MIE AO OECD Status OECD Project
17 Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory Marie-Gabrielle Zurich BY-SA 1487: Binding, Thiol/seleno-proteins involved in protection against oxidative stress 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.13
37 PPARĪ± activation leading to hepatocellular adenomas and carcinomas in rodents Chris Corton BY-SA 227: Activation, PPARĪ± 719: Increase, hepatocellular adenomas and carcinomas Under Development 1.17
296 Oxidative DNA damage leading to chromosomal aberrations and mutations Carole Yauk BY-SA 1634: Increase, Oxidative DNA damage WPHA/WNT Endorsed 1.76
470 Deposition of energy leads to abnormal vascular remodeling Vinita Chauhan BY-SA 1686: Deposition of Energy 2069: Occurrence, Abnormal Vascular Remodeling WPHA/WNT Endorsed 1.89
478 Deposition of energy leading to occurrence of cataracts Vinita Chauhan BY-SA 1686: Deposition of Energy 2083: Occurrence of Cataracts WPHA/WNT Endorsed 1.89
482 Deposition of energy leading to occurrence of bone loss Vinita Chauhan BY-SA 1686: Deposition of Energy 2091: Occurrence, Bone Loss WPHA/WNT Endorsed 1.89
483 Deposition of Energy Leading to Learning and Memory Impairment Vinita Chauhan BY-SA 1686: Deposition of Energy 341: Impairment, Learning and memory WPHA/WNT Endorsed 1.89
492 Glutathione conjugation leading to reproductive dysfunction via oxidative stress Leonardo Vieira All rights reserved 2131: Conjugation, GSH 406: decreased, Fertility
593 Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons Stefan Schildknecht BY-SA 2362: Redox cycling of a chemical by mitochondria 896: Parkinsonian motor deficits
622 Calcineurin inhibitor induced nephrotoxicity leading to kidney failure Kate Liang All rights reserved None 759: Increased, Kidney Failure