AOP-Wiki

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All Key Events

Showing 1126 to 1150 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1584	Interaction of α-diketones with arginine residues Short Name	0	Molecular	Jan 30, 2019	Jan 30, 2019	280: α-diketone-induced bronchiolitis obliterans
1585	Proteasomal dysfunction Short Name Proteasomal dysfunction	0	Molecular	Jan 30, 2019	Jan 30, 2019	2 AOPs 280: α-diketone-induced bronchiolitis obliterans 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
1586	Airway epithelial injury Short Name Airway epithelial injury	0	Cellular	Jan 30, 2019	Jan 30, 2019	2 AOPs 280: α-diketone-induced bronchiolitis obliterans 481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
1587	Fibroproliferative airway lesions Short Name Fibroproliferative airway lesions	0	Tissue	Jan 30, 2019	Jan 30, 2019	280: α-diketone-induced bronchiolitis obliterans
1588	Bronchiolitis obliterans Short Name Bronchiolitis obliterans	0	Individual	Jan 30, 2019	Jan 30, 2019	280: α-diketone-induced bronchiolitis obliterans
1589	Systemic or topical administration of chemicals Short Name Administration of chemicals	0	Molecular	Feb 3, 2019	Feb 3, 2019	None
1590	Distribution and deposition of chemicals to skin and/or eyes Short Name Distribution of chemicals	0	Molecular	Feb 3, 2019	Feb 3, 2019	None
1591	Absorption of photon energy Short Name Absorption of photon energy	0	Molecular	Feb 3, 2019	Feb 5, 2019	None
1593	Radicals of target chemicals Short Name Radical generation	0	Molecular	Feb 3, 2019	Feb 3, 2019	None
1594	Oxidation of membrane lipids Short Name Oxidation of membrane lipids	0	Cellular	Feb 3, 2019	Jul 4, 2019	282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
1595	Oxidation/denatuation of membrane proteins Short Name	0	Cellular	Feb 3, 2019	Jul 4, 2019	282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
1596	Oxidation of DNA Short Name Oxidation of DNA	0	Cellular	Feb 3, 2019	Feb 3, 2019	None
1597	Formation of DNA photo-adducts Short Name DNA photo-adducts	0	Cellular	Feb 3, 2019	Feb 3, 2019	None
1598	Formation of protein photo-adducts Short Name Protein photo-adducts	0	Cellular	Feb 3, 2019	Feb 3, 2019	None
1599	Inflamatory events in light-exposed tissues Short Name Inflammatory events	0	Organ	Feb 3, 2019	Jul 4, 2019	2 AOPs 282: Adverse outcome pathway on photochemical toxicity initiated by light exposure 495: Androgen receptor activation leading to prostate cancer
1600	Eczematous eruption (Erythema, Papules, Vesicles, Pruritius, Weeping, Oozing, Crusting) Short Name Eczematous eruption	0	Organ	Feb 3, 2019	Feb 3, 2019	None
1601	Scaling, Lichenification Short Name Scaling, Lichenification	0	Organ	Feb 3, 2019	Feb 3, 2019	None
1602	Increased Muscarinic Acetylcholine Receptors Short Name	1	Molecular	Feb 6, 2019	Dec 2, 2024	3 AOPs 281: Acetylcholinesterase Inhibition Leading to Neurodegeneration 551: Increased Muscarinic M2 Receptor leading to Arrhythmia 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
1603	Chronic kidney disease Short Name Chronic kidney disease	0	Organ	Feb 18, 2019	Feb 18, 2019	2 AOPs 284: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease 384: Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease
1604	Inhibition of N-linked glycosylation Short Name Inhibition of N-linked glycosylation	0	Molecular	Mar 6, 2019	Mar 6, 2019	285: Inhibition of N-linked glycosylation leads to liver injury
1605	Accumulation of misfolded proteins Short Name Accumulation, misfolded proteins	0	Cellular	Mar 6, 2019	Mar 6, 2019	2 AOPs 285: Inhibition of N-linked glycosylation leads to liver injury 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
1606	Activation, Stellate cell Short Name Activation, Stellate cell	0	Cellular	Mar 6, 2019	Feb 11, 2026	285: Inhibition of N-linked glycosylation leads to liver injury
1607	Increase, Necrosis Short Name Increase, Necrosis	0	Tissue	Mar 19, 2019	Mar 19, 2019	413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure
1609	Inhibition, Cytochrome P450 enzyme (CYP17A1) activity Short Name Inhibition of Cyp17A1 activity	0	Molecular	Apr 10, 2019	Apr 8, 2025	288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)
1610	Reduction, dehydroepiandrosterone Short Name Reduction, DHEA	0	Tissue	Apr 10, 2019	Apr 8, 2025	288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals)