AOP-Wiki

API

All Key Events

Showing 601 to 625 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1832	Coordinated gene expression changes by PPARα activation Short Name Coordinated gene expression changes	1	Molecular	Dec 19, 2020	Dec 19, 2020	None
1831	Binding, Thyroid binding globulin in serum Short Name	0	Molecular	Dec 9, 2020	Nov 19, 2025	367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
1830	Displacement, Serum thyroxine (T4) from carrier protein Short Name	0	Molecular	Dec 9, 2020	Dec 9, 2020	2 AOPs 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
1829	Altered, Thyroid hormone-dependent gene expression Short Name Altered, TH-dependent gene expression	0	Molecular	Dec 9, 2020	Dec 9, 2020	4 AOPs 190: Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis 191: Type III iodotyrosine deiodinase (DIO3) inhibition leading to altered amphibian metamorphosis 393: AOP for thyroid disorder caused by triphenyl phosphate via TRβ activation 402: Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain
1828	Increased, Thyroxine (T4) in serum Short Name Increased, Thyroxine (T4) in serum	0	Organ	Dec 9, 2020	Dec 9, 2020	190: Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis
1827	Increase, Global DNA methylation Short Name Increase, Global methylation	0	Molecular	Dec 4, 2020	Dec 4, 2020	None
1826	Increase, Oxygen consumption Short Name Increase, Oxygen consumption	0	Cellular	Dec 4, 2020	Dec 4, 2020	None
1825	Increase, Cell death Short Name Increase, Cell death	2	Cellular	Dec 4, 2020	Nov 27, 2024	12 AOPs 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2) 287: Mitochondrial complex III antagonism leading to growth inhibition (2) 368: Cytochrome oxidase inhibition leading to increased nasal lesions 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear 418: Aryl hydrocarbon receptor activation leading to impaired lung function through AHR-ARNT toxicity pathway 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death) 482: Deposition of energy leading to occurrence of bone loss 573: Inhibition, cytochrome oxidase leads to Increased, pulmonary edema 574: Inhibition, cytochrome oxidase leads to Loss of olfactory function 472: DNA adduct formation leading to kidney failure
1824	Decrease, Fatty acid β-oxidation Short Name Decrease, FAO	0	Cellular	Nov 25, 2020	Nov 25, 2020	646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
1822	Maturation of TNF/iNOS-Producing Dendritic Cells Short Name	0	Cellular	Nov 23, 2020	Nov 23, 2020	313: Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
1821	Decrease, Cell proliferation Short Name Decrease, Cell proliferation	1	Cellular	Nov 12, 2020	Dec 7, 2020	16 AOPs 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 286: Mitochondrial complex III antagonism leading to growth inhibition (1) 399: Inhibition of Fyna leading to increased mortality via decreased eye size (Microphthalmos) 460: Antagonism of Smoothened receptor leading to orofacial clefting 267: Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion 491: Decrease, GLI1/2 target gene expression leads to orofacial clefting 502: Decrease, cholesterol synthesis leads to orofacial clefting 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration 598: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell proliferation 602: Excessive reactive oxygen species leading to growth inhibition via oxidative DNA damage 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation 324: Reactive oxygen species leading to growth inhibition via oxidative DNA damage and cell cycle disruption 326: Reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation 332: Reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation
1820	Immune mediated hepatitis Short Name hepatitis	0	Organ	Nov 2, 2020	Nov 2, 2020	362: Immune mediated hepatitis
1819	IFNγ signaling Short Name IFNγ signaling	0	Cellular	Nov 2, 2020	Nov 2, 2020	362: Immune mediated hepatitis
1818	Immune cell activation Short Name Immune cell activation	0	Cellular	Nov 2, 2020	Nov 2, 2020	362: Immune mediated hepatitis
1817	Apoptotic cell death Short Name Apoptotic cell death	0	Cellular	Nov 2, 2020	Nov 2, 2020	2 AOPs 362: Immune mediated hepatitis 423: Toxicological mechanisms of hepatocyte apoptosis through the PARP1 dependent cell death pathway
1816	Mitochondrial dysfunction EMPTY Short Name Mitochondrial dysfunction EMPTY	0	Cellular	Nov 2, 2020	Apr 17, 2024	429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
1815	Increase, Endoplasmic reticulum stress Short Name Increase, ER stress	0	Cellular	Nov 2, 2020	Feb 11, 2026	4 AOPs 362: Immune mediated hepatitis 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways 626: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via insulin resistance-associated endoplasmic reticulum stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
1814	benzoquinone imine and acylglucuronide metabolites Short Name Reactive Metabolite	0	Molecular	Nov 2, 2020	Nov 2, 2020	362: Immune mediated hepatitis
1813	Increase, Mitochondrial complex I dysfunction Short Name Increase, Complex I dysfunction	0	Molecular	Nov 2, 2020	Nov 2, 2020	None
1812	Increase, Cytochrome c release Short Name Increase, Cyt c release	0	Cellular	Nov 2, 2020	Nov 2, 2020	464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
1811	Increase, Mitochondrial complex III dysfunction Short Name Increase, Complex III dysfunction	0	Molecular	Nov 2, 2020	Nov 2, 2020	None
1810	Decrease, Plasma membrane ATPase activity Short Name Decrease, ATPase activity	0	Cellular	Nov 2, 2020	Nov 2, 2020	None
1809	Increase, Tissue/organ damage Short Name Increase, Tissue/organ damage	0	Organ	Nov 2, 2020	Nov 2, 2020	377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1808	Decrease, ATP synthase activity Short Name Decrease, ATP synthase activity	0	Molecular	Nov 2, 2020	Nov 2, 2020	None
1807	Inhibition, Chitobiase Short Name Inhibition, Chitobiase	0	Molecular	Oct 21, 2020	Sep 8, 2021	359: Chitobiase inhibition leading to mortality