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All Key Events

Showing 701 to 725 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1705	Impaired coordination and movement Short Name Impaired coordination and movement	0	Individual	Dec 20, 2019	Dec 20, 2019	312: Acetylcholinesterase Inhibition leading to Acute Mortality via Impaired Coordination & Movement
1704	testJF Short Name test	0	Molecular	Dec 5, 2019	Dec 5, 2019	None
1703	Dysregulation of heart rate and vascular tone Short Name Cardiovascular dysregulation	0	Organ	Nov 25, 2019	Dec 20, 2019	16: Acetylcholinesterase inhibition leading to acute mortality
1702	Suppression of T cell activation Short Name Suppression of T cell activation	1	Cellular	Nov 17, 2019	Mar 6, 2023	277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
1701	Suppression of NF-kB Short Name Suppression of NF-kB	0	Molecular	Nov 17, 2019	Nov 17, 2019	None
1700	Impaired IL-1R1 signaling in T cell Short Name Impaired IL-1R1 signaling	1	Molecular	Nov 17, 2019	Mar 2, 2023	277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
1699	Decrease, expression of gonadotropin releasing hormone receptor Short Name Decease, expression of GnRHR	0	Molecular	Oct 30, 2019	Oct 30, 2019	310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
1698	Increase, hypermethylation of the promotor region of gonadotropin releasing hormone receptor Short Name	0	Molecular	Oct 30, 2019	Oct 30, 2019	310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
1697	Increase, DNA methyltransferase expression Short Name Increase, DNMT expression	0	Molecular	Oct 30, 2019	Oct 30, 2019	310: Embryonic Activation of the AHR leading to Reproductive failure, via epigenetic down-regulation of GnRHR
1696	Decrease of egg production and cummulative fecundity Short Name	0	Individual	Oct 3, 2019	Oct 3, 2019	3 AOPs 309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction 396: Deposition of ionizing energy leads to population decline via impaired meiosis 595: Emerging OPFRS reproductive outcome pathway
1695	Impaired ovulation Short Name Impaired ovulation	1	Organ	Oct 3, 2019	Jan 3, 2025	2 AOPs 309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction 566: Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation
1694	Reduction, progesterone uptake, decresed maturation Short Name	0	Cellular	Oct 3, 2019	Oct 3, 2019	309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
1693	Decreased, Progesterone levels Short Name Decreased, Progesterone levels	0	Tissue	Oct 3, 2019	Apr 8, 2025	309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
1692	Reduction, Progesterone synthesis Short Name Reduction, Progesterone synthesis	0	Cellular	Oct 3, 2019	Oct 3, 2019	309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
1691	Antagonism,LH receptor Short Name Antagonism,LH receptor	0	Molecular	Oct 3, 2019	Oct 3, 2019	309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
1690	Decrease, circulating testosterone levels Short Name	2	Tissue	Aug 30, 2019	Mar 20, 2026	12 AOPs 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 526: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Impaired, Spermatogenesis 124: HMG-CoA reductase inhibition leading to decreased fertility 18: PPARα activation in utero leading to impaired fertility in males 51: PPARα activation leading to impaired fertility in adult male rodents 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility 120: Inhibition of 5α-reductase leading to Leydig cell tumors (in rat) 288: Inhibition of 17α-hydrolase/C 10,20-lyase (Cyp17A1) activity leads to birth reproductive defects (cryptorchidism) in male (mammals) 570: Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring 575: Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring 595: Emerging OPFRS reproductive outcome pathway
1688	anogenital distance (AGD), decreased Short Name AGD, decreased	1	Tissue	Aug 30, 2019	Dec 22, 2022	4 AOPs 305: 5α-reductase inhibition leading to short anogenital distance (AGD) in male (mammalian) offspring 306: Androgen receptor (AR) antagonism leading to short anogenital distance (AGD) in male (mammalian) offspring 307: Decreased testosterone synthesis leading to short anogenital distance (AGD) in male (mammalian) offspring 476: Adverse Outcome Pathways diagram related to PBDEs associated male reproductive toxicity
1686	Deposition of Energy Short Name Energy Deposition	1	Molecular	Aug 22, 2019	Aug 23, 2024	17 AOPs 272: Deposition of energy leading to lung cancer 432: Deposition of Energy by Ionizing Radiation leading to Acute Myeloid Leukemia 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 388: Deposition of ionising energy leading to population decline via programmed cell death 435: Deposition of ionising energy leads to population decline via pollen abnormal 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 441: Ionizing radiation-induced DNA damage leads to microcephaly via apoptosis and premature cell differentiation 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 470: Deposition of energy leads to abnormal vascular remodeling 473: Energy deposition from internalized Ra-226 decay lower oxygen binding capacity of hemocyanin 478: Deposition of energy leading to occurrence of cataracts 482: Deposition of energy leading to occurrence of bone loss 483: Deposition of Energy Leading to Learning and Memory Impairment
1685	Anomalies, Congenital cardiac conotruncal Short Name	0	Individual	Aug 13, 2019	Aug 13, 2019	304: TBX1 inhibition leading to congenital cardiac conotruncal anomalies
1684	Abnormalities, Cardiac outflow tract formation Short Name	0	Organ	Aug 13, 2019	Aug 13, 2019	304: TBX1 inhibition leading to congenital cardiac conotruncal anomalies
1683	Impairment, Fourth pharyngeal arch development Short Name	0	Tissue	Aug 13, 2019	Aug 13, 2019	304: TBX1 inhibition leading to congenital cardiac conotruncal anomalies
1682	Disruption, Progenitor cells of second heart field Short Name	0	Cellular	Aug 13, 2019	Feb 15, 2022	2 AOPs 304: TBX1 inhibition leading to congenital cardiac conotruncal anomalies 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
1681	Disruption, Neural crest cell migration Short Name Disruption, Neural crest cell migration	0	Cellular	Aug 13, 2019	Aug 13, 2019	304: TBX1 inhibition leading to congenital cardiac conotruncal anomalies
1680	Inhibition, TBX1 Short Name Inhibition, TBX1	0	Molecular	Aug 13, 2019	Aug 13, 2019	304: TBX1 inhibition leading to congenital cardiac conotruncal anomalies
1679	Acute inhalation toxicity Short Name Acute inhalation toxicity	0	Individual	Jul 3, 2019	Jul 3, 2019	None