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Showing 1601 to 1625 of 1939 Key Events

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ID Title Event Component Count Biological Organization Created At Last Updated AOPs
664 Overwhelmed, Mitochondrial DNA repair mechanisms
1 Cellular Nov 29, 2016 Sep 16, 2017 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
663 Desensitization, Nicotinic acetylcholine receptor
2 Molecular Nov 29, 2016 Jun 7, 2018
662 Decreased testosterone by the fetal Leydig cells, Hypermethylation in the fetal testis
1 Molecular Nov 29, 2016 Dec 3, 2016 74: Modulation of Adult Leydig Cell Function Subsequent to Hypermethylation in the Fetal Testis
661 Decreased testosterone by the fetal Leydig cells, Alterations in the fetal testis proteome
1 Molecular Nov 29, 2016 Dec 3, 2016 68: Modulation of Adult Leydig Cell Function Subsequent to Alterations in the Fetal Testis Protome
660 decreased testosterone by fetal Leydig cells, Dysgenesis of fetal Leydig cells
2 Organ Nov 29, 2016 Sep 16, 2017 67: Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis
659 Decreased testosterone by the fetal Leydig cells, Activation by other estradiol agonists
1 Cellular Nov 29, 2016 Dec 3, 2016 67: Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis
658 Decreased testosterone by the fetal Leydig cells, Increased estradiol
1 Cellular Nov 29, 2016 Sep 16, 2017 67: Modulation of Adult Leydig Cell Function Subsequent to Estradiaol Activation in the Fetal Testis
657 Decreased testosterone by the fetal Leydig cells, Dysgenesis of fetal Leydig cells
2 Organ Nov 29, 2016 Dec 3, 2016
656 Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII)
1 Cellular Nov 29, 2016 Dec 3, 2024
655 Decreased testosterone by the fetal Leydig cells, Increased COUP-TFII in fetal Leydig cells
1 Cellular Nov 29, 2016 Dec 3, 2016
654 Decreased testosterone by the fetal Leydig cells, Activation by other glucocorticoid receptor agonists
1 Cellular Nov 29, 2016 Dec 3, 2016 66: Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis
653 Decreased testosterone by the fetal Leydig cells, Increased corticosterone
1 Cellular Nov 29, 2016 Sep 16, 2017 66: Modulation of Adult Leydig Cell Function Subsequent Glucocorticoid Activation in the Fetal Testis
652 Direct effects of Corticosterone on steroidogenesis, Decreased testosterone by adult Leydig cells
1 Cellular Nov 29, 2016 Dec 3, 2016 71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
651 Glucocorticoid Receptor mediated alterations in steriodogenic enzymes, Decreased testosterone by adult Leydig cells
1 Cellular Nov 29, 2016 Dec 3, 2016 71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
650 Stimulation of adult Leydig cells via the Adrenal Corticosterone, Increased Glucocorticoid
2 Molecular Nov 29, 2016 Dec 3, 2016 71: Modulation of Adult Leydig Cell Function Subsequent to Glucocorticoid Activation
649 Decreased steroidogenesis, Alterations in the Leydig Cell Cytoskeleton
1 Tissue Nov 29, 2016 Sep 16, 2017 70: Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell
648 Decreased steroidogenesis, Increased Apoptosis of Adult Leydig Cells
1 Tissue Nov 29, 2016 Sep 16, 2017 70: Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell
647 Decreased, steroidogenic protein expression
1 Cellular Nov 29, 2016 Dec 3, 2024
646 Decreased Cholesterol, Decreased sperm quantity and/or quality in the adult testis
1 Organ Nov 29, 2016 Dec 3, 2016 69: Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell
645 Decreased Cholesterol, Decreased Testosterone Production by Adult Leydig Cells
1 Cellular Nov 29, 2016 Sep 16, 2017 69: Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell
644 Decreased Cholesterol, Decreased Transport of Cholesterol to the Inner Mitochondrial Membrane
1 Molecular Nov 29, 2016 Dec 3, 2016 69: Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell
643 Decreased Cholesterol, Decreased Uptake of Lipoproteins
1 Molecular Nov 29, 2016 Sep 16, 2017 69: Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell
642 Decreased Cholesterol, Decreased De Novo Biosynthesis of Choleseterol
1 Molecular Nov 29, 2016 Sep 16, 2017 69: Modulation of Adult Leydig Cell Function Subsequent to Decreased Cholesterol Synthesis or Transport in the Adult Leydig Cell
640 Decreased steroidogenesis, Proteomic alterations in the adult Leydig cell
1 Molecular Nov 29, 2016 Sep 16, 2017 70: Modulation of Adult Leydig Cell Function Subsequent to Proteomic Alterations in the Adult Leydig Cell
638 Antagonism, Histamine Receptor (H2)
1 Molecular Nov 29, 2016 Sep 16, 2017 99: Histamine (H2) receptor antagonism leading to reduced survival