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All Key Events

Showing 401 to 425 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

760	Activation, Glutamate-gated chloride channel Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	113: Glutamate-gated chloride channel activation leading to acute mortality
761	Increased, Chloride conductance Short Name Increased, Chloride conductance	1	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 113: Glutamate-gated chloride channel activation leading to acute mortality 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality
762	Activation, ionotropic GABA Receptor chloride channel Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality
763	hyperpolarisation, neuron Short Name hyperpolarisation, neuron	1	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 113: Glutamate-gated chloride channel activation leading to acute mortality 233: Mu Opioid Receptor Agonism leading to Analgesia via K Channel Opening 235: Serotonin 1A Receptor Agonism leading to Anti-depressant Activity via K Channel Opening
764	N/A, Ataxia, paralysis, or hyperactivity Short Name	3	Organ	Nov 29, 2016	Sep 16, 2017	113: Glutamate-gated chloride channel activation leading to acute mortality
765	Decreased, population 1 Short Name Decreased, population 1	1	Population	Nov 29, 2016	Dec 3, 2016	113: Glutamate-gated chloride channel activation leading to acute mortality
766	Inhibition, 4-hydroxyphenyl-pyruvate dioxygenase (HPPD) enzyme Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	114: HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
767	Increase, Hyperplasia (renal tubular cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	105: Alpha2u-microglobulin cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
768	Increase, Cytotoxicity Short Name Increase, Cytotoxicity	2	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat) 136: Intracellular Acidification Induced Olfactory Epithelial Injury Leading to Site of Contact Nasal Tumors 284: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease
769	Increase, Oxidative metabolism Short Name Increase, Oxidative metabolism	1	Cellular	Nov 29, 2016	Dec 3, 2016	108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
770	Increase, Cytotoxicity (club cells) Short Name Increase, Cytotoxicity (club cells)	1	Cellular	Nov 29, 2016	Sep 16, 2017	109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
771	Decrease, Serum thyroid hormone (T4/T3) Short Name Decrease, Serum thyroid hormone (T4/T3)	1	Tissue	Nov 29, 2016	Sep 16, 2017	402: Thyroid peroxidase (TPO) inhibition leads to periventricular heterotopia formation in the developing rat brain
772	Increase, Hyperplasia (glandular epithelial cells of endometrium) Short Name	2	Cellular	Nov 29, 2016	Sep 18, 2025	3 AOPs 112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) 503: Activation of uterine estrogen receptor-alfa leading to endometrial adenocarcinoma, via epigenetic modulation 167: Early-life estrogen receptor agonism leading to endometrial adenosquamous carcinoma via promotion of sine oculis homeobox 1 progenitor cells
773	Increase, Endometrial adenocarcinomas Short Name Increase, Endometrial adenocarcinomas	2	Tissue	Nov 29, 2016	Sep 16, 2017	112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
774	Increase, Preneoplastic foci (hepatocytes) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) 118: Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
775	Increased, Plasma tyrosine Short Name Increased, Plasma tyrosine	1	Tissue	Nov 29, 2016	Sep 16, 2017	114: HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
776	Increase, Cytotoxicity (corneal cells) Short Name Increase, Cytotoxicity (corneal cells)	1	Cellular	Nov 29, 2016	Sep 16, 2017	114: HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
777	Increase, Inflammation (corneal cells) Short Name Increase, Inflammation (corneal cells)	1	Cellular	Nov 29, 2016	Sep 16, 2017	114: HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
778	Increase, Regenerative cell proliferation (corneal cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	114: HPPD inhibition leading to corneal papillomas and carcinomas (in rat)
779	Increase, Papillomas/carcinomas (squamous cells) Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 114: HPPD inhibition leading to corneal papillomas and carcinomas (in rat) 115: Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
780	Increase, Cytotoxicity (epithelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 115: Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat) 451: Interaction with lung resident cell membrane components leads to lung cancer
781	Increase, Regenerative cell proliferation (forestomach epithelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	115: Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
782	Increase, Hyperplasia (forestomach epithelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	115: Epithelial cytotoxicity leading to forestomach tumors (in mouse and rat)
783	Increase, Cytotoxicity (tubular epithelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	116: Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)
784	Increase, Hyperplasia (tubular epithelial cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	116: Cytotoxicity leading to renal tubular adenomas and carcinomas (in male rat)