Key Event Relationships (KERs)

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Showing 226 to 250 of 3081 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
1391 1297: Activation, insulin receptor 1298: Activation, mTORC2 Apr 12, 2017 Apr 12, 2017 None
1051 762: Activation, ionotropic GABA Receptor chloride channel 761: Increased, Chloride conductance Nov 29, 2016 Dec 3, 2016
1369 1282: Activation, JAK/STAT pathway 1283: Activation, TGF-beta pathway Feb 15, 2017 Feb 15, 2017
1380 1292: Activation, JNK 1293: Activation, FOXO Feb 15, 2017 Feb 15, 2017
2149 1292: Activation, JNK 1793: AP-1 activation Jul 9, 2020 Jul 9, 2020
2150 1292: Activation, JNK 1794: Pin-1 activation Jul 9, 2020 Jul 9, 2020
1261 1205: Activation, Juvenile hormone receptor 1206: Induction, Doublesex1 gene Nov 29, 2016 Dec 3, 2016
834 826: Activation, Keratinocytes 398: Activation, Dendritic Cells Nov 29, 2016 Dec 3, 2016
1401 1302: Activation, L-FABP 1305: Increase, cytosolic fatty acid Apr 12, 2017 Apr 12, 2017 None
1423 1302: Activation, L-FABP 228: demethylation, PPARg promoter Apr 13, 2017 Apr 13, 2017 None
1651 1468: TGFbeta1 activation 1469: TGFbeta pathway activation Aug 16, 2017 Aug 16, 2017
172 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes 139: N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects Nov 29, 2016 Nov 29, 2016
874 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes 853: Changes/Inhibition, Cellular Homeostasis and Apoptosis Nov 29, 2016 Nov 29, 2016
875 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes 854: Alterations, Cellular proliferation / hyperplasia Nov 29, 2016 Nov 29, 2016
876 165: Activation, Long term AHR receptor driven direct and indirect gene expression changes 856: Formation, Hepatocellular and Bile duct tumors Nov 29, 2016 Nov 29, 2016
1425 1314: Activation, LRH-1 116: Activation, FAS Apr 13, 2017 Apr 13, 2017 None
173 167: Activation, LXR 54: Up Regulation, CD36 Nov 29, 2016 Dec 3, 2016
174 167: Activation, LXR 66: Activation, ChREBP Nov 29, 2016 Dec 3, 2016
175 167: Activation, LXR 116: Activation, FAS Nov 29, 2016 Dec 3, 2016
176 167: Activation, LXR 258: Activation, SCD-1 Nov 29, 2016 Dec 3, 2016
177 167: Activation, LXR 264: Activation, SREBP-1c Nov 29, 2016 Dec 3, 2016
479 167: Activation, LXR 457: Activation, SREBF1 Nov 29, 2016 Dec 3, 2016
490 167: Activation, LXR 463: Up Regulation, FAS Nov 29, 2016 Dec 3, 2016
491 167: Activation, LXR 462: Up Regulation, SCD-1 Nov 29, 2016 Dec 3, 2016
510 167: Activation, LXR 468: Inhibition, PPAR alpha Nov 29, 2016 Dec 3, 2016