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Showing 2576 to 2600 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3070	352: N/A, Neurodegeneration	388: Overactivation, NMDARs	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
3075	352: N/A, Neurodegeneration	637: impaired, Learning and memory	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
3081	352: N/A, Neurodegeneration	1348: Increase, seizure	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
242	213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin	21: Altered regulation, Alpha hemoglobin	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
243	213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin	118: Formation, Formation of hemoglobin adducts	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
245	213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin	250: Damaging, Red blood cells; hemolysis	Nov 29, 2016	Dec 3, 2016	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
3323	213: N/A, Parent compound is converted to the reactive metabolite and forms free radicals leadin	1392: Increase, Oxidative Stress	Jul 24, 2024	Jul 24, 2024	1 AOP 31: Oxidation of iron in hemoglobin leading to hematotoxicity
650	634: N/A, sedation	635: Decreased, locomotion	Nov 29, 2016	Dec 3, 2016	1 AOP 99: Histamine (H2) receptor antagonism leading to reduced survival
324	294: N/A, Unknown	57: Proliferation, Cell proliferation in the absence of cytotoxicity	Nov 29, 2016	Dec 3, 2016	1 AOP 1: Uncharacterized liver damage leading to hepatocellular carcinoma
751	294: N/A, Unknown	759: Increased, Kidney Failure	Nov 29, 2016	Dec 3, 2016	1 AOP 33: Kidney toxicity induced by activation of 5HT2C
3148	1259: narcosis	177: Increase, Mitochondrial dysfunction	Mar 13, 2024	Mar 13, 2024	1 AOP 205: AOP from chemical insult to cell death
1789	1548: Necrotic Tissue	1549: Liver Injury	Dec 19, 2018	Mar 7, 2019	2 AOPs 273: Mitochondrial complex inhibition leading to liver injury 278: IKK complex inhibition leading to liver injury
1803	1557: Reduced neural crest cell migration	1558: Reduced collagen production	Dec 20, 2018	Dec 20, 2018	1 AOP 274: Histone deacetylase inhibition leads to impeded craniofacial development
2563	1557: Reduced neural crest cell migration	1970: Transposition of the great arteries	Feb 8, 2022	Feb 15, 2022	1 AOP 436: Inhibition of RALDH2 causes reduced all-trans retinoic acid levels, leading to transposition of the great arteries
208	188: Neuroinflammation	352: N/A, Neurodegeneration	Nov 29, 2016	Feb 23, 2021	4 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis 471: Neuron defect induced early behavioral change
759	188: Neuroinflammation	385: Synaptogenesis, Decreased	Nov 29, 2016	Dec 3, 2016	None
906	188: Neuroinflammation	890: Degeneration of dopaminergic neurons of the nigrostriatal pathway	Nov 29, 2016	Aug 25, 2017	2 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 471: Neuron defect induced early behavioral change
1687	188: Neuroinflammation	55: Cell injury/death	Nov 9, 2017	Nov 7, 2019	2 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms
2288	188: Neuroinflammation	1841: Encephalitis	Feb 23, 2021	Feb 23, 2021	1 AOP 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis
2500	188: Neuroinflammation	386: Neuronal network function, Decreased	Oct 26, 2021	Oct 26, 2021	1 AOP 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
2717	188: Neuroinflammation	1825: Increase, Cell death	Jul 25, 2022	Jul 25, 2022	None
3255	188: Neuroinflammation	341: Impairment, Learning and memory	Jun 19, 2024	Jun 19, 2024	1 AOP 535: Binding and activation of GPER leading to learning and memory impairments
210	191: Neuronal dysfunction	188: Neuroinflammation	Nov 29, 2016	Nov 29, 2016	None
2941	191: Neuronal dysfunction	2150: Neurological disorder	Jun 15, 2023	Jun 15, 2023	2 AOPs 498: Increased LCN2/iron complex leading to neurological disorders 471: Neuron defect induced early behavioral change
2457	1915: Neutrophil activation, Increased	1857: Platelet-neutrophil interactions, Increased	Aug 4, 2021	Aug 4, 2021	1 AOP 412: Endothelial cell dysfunction leading to thromboinflammation

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