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Showing 326 to 350 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

301	272: Activation/Proliferation, T-cells	312: N/A, Allergic contact dermatitis on challenge	Nov 29, 2016	Dec 3, 2016	None
835	272: Activation/Proliferation, T-cells	827: sensitisation, skin	Nov 29, 2016	Dec 3, 2016	1 AOP 40: Covalent Protein binding leading to Skin Sensitisation
1701	272: Activation/Proliferation, T-cells	313: Increase, Allergic Respiratory Hypersensitivity Response	Dec 7, 2017	Aug 1, 2022	1 AOP 39: Covalent Binding, Protein, leading to Increase, Allergic Respiratory Hypersensitivity Response
3332	272: Activation/Proliferation, T-cells	2256: Activation of gluten- and TG2-reactive B cells	Aug 13, 2024	Aug 13, 2024	None
3334	272: Activation/Proliferation, T-cells	1931: Disruption of the intestinal barrier	Aug 13, 2024	Aug 13, 2024	None
3337	272: Activation/Proliferation, T-cells	2252: Formation of HLA-DQ2/8-gluten complexes	Aug 13, 2024	Aug 13, 2024	None
2157	1793: AP-1 activation	1795: TGFbeta expression	Jul 9, 2020	Jul 9, 2020	1 AOP 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
2523	1937: ADAM17 induction	1938: ACE2 increased shedding	Oct 28, 2021	Oct 28, 2021	None
2696	2025: Affected folate transporter	2026: decrease folate	Jul 19, 2022	Jul 19, 2022	1 AOP 449: Ceramide synthase inhibition leading to neural tube defects
31	25: Agonism, Androgen receptor	129: Reduction, Gonadotropins, circulating concentrations	Nov 29, 2016	Mar 20, 2017	1 AOP 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
32	25: Agonism, Androgen receptor	274: Reduction, Testosterone synthesis by ovarian theca cells	Nov 29, 2016	Mar 20, 2017	1 AOP 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
1384	25: Agonism, Androgen receptor	3: Reduction, 17beta-estradiol synthesis by ovarian granulosa cells	Mar 17, 2017	Mar 20, 2017	1 AOP 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
1385	25: Agonism, Androgen receptor	285: Reduction, Vitellogenin synthesis in liver	Mar 17, 2017	Mar 20, 2017	1 AOP 23: Androgen receptor agonism leading to reproductive dysfunction (in repeat-spawning fish)
2260	25: Agonism, Androgen receptor	1790: Increased, Differentiation to Testis	Jan 12, 2021	Jan 3, 2023	1 AOP 376: Androgen receptor agonism leading to male-biased sex ratio
2349	25: Agonism, Androgen receptor	1791: Increased, Male Biased Sex Ratio	Apr 12, 2021	Jan 3, 2023	1 AOP 376: Androgen receptor agonism leading to male-biased sex ratio
2926	25: Agonism, Androgen receptor	2139: Reduction, the ratio of E2/11-KT in plasma	May 22, 2023	May 22, 2023	None
3378	25: Agonism, Androgen receptor	2274: Androgen receptor activation, increased	Nov 2, 2024	Nov 24, 2024	1 AOP 547: Androgen receptor agonism leading to long anogenital distance in female offspring
3392	25: Agonism, Androgen receptor	286: Altered, Transcription of genes by the AR	Nov 16, 2024	Nov 16, 2024	2 AOPs 496: Androgen receptor agonism leading to reproduction dysfunction （in zebrafish） 495: Androgen receptor activation leading to prostate cancer
3450	25: Agonism, Androgen receptor	716: Increase, cell proliferation (hepatocytes)	Dec 23, 2024	Dec 23, 2024	1 AOP 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat)
3462	25: Agonism, Androgen receptor	1599: Inflammatory events	Dec 31, 2024	Dec 31, 2024	1 AOP 495: Androgen receptor activation leading to prostate cancer
3463	25: Agonism, Androgen receptor	1183: Decreased, Apoptosis (Epithelial Cells)	Dec 31, 2024	Dec 31, 2024	1 AOP 495: Androgen receptor activation leading to prostate cancer
126	111: Agonism, Estrogen receptor	363: Altered, Reproductive behaviour	Nov 29, 2016	Dec 3, 2016	1 AOP 29: Estrogen receptor agonism leading to reproductive dysfunction
127	111: Agonism, Estrogen receptor	364: Impaired development of, Reproductive organs	Nov 29, 2016	Dec 3, 2016	1 AOP 29: Estrogen receptor agonism leading to reproductive dysfunction
128	111: Agonism, Estrogen receptor	307: Increase, Vitellogenin synthesis in liver	Nov 29, 2016	Jun 24, 2024	3 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
3525	111: Agonism, Estrogen receptor	749: Decreased, Progesterone from corpus luteum	Apr 17, 2025	Apr 17, 2025	1 AOP 112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)

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