Key Event Relationships (KERs)

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Showing 2076 to 2100 of 3081 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
2868 1350: Increased, glutamate 2123: decreased, Bcl-2 Apr 4, 2023 Apr 4, 2023
2869 1350: Increased, glutamate 2124: increased, Bax Apr 4, 2023 Apr 4, 2023
1206 1158: Increased, Hepatic thyroid hormone uptake/transport 401: Increase, Biliary excretion TH glucuronide Nov 29, 2016 Dec 3, 2016 None
2237 1158: Increased, Hepatic thyroid hormone uptake/transport 281: T4 in serum, Decreased Dec 9, 2020 Dec 9, 2020
2479 1158: Increased, Hepatic thyroid hormone uptake/transport 961: Increased, Clearance of thyroxine from serum Sep 10, 2021 Sep 10, 2021
803 802: Increased, HIF-1 alpha transcription 799: Increased, HIF-1 heterodimer Nov 29, 2016 Dec 3, 2016
800 799: Increased, HIF-1 heterodimer 800: Decreased, Aromatase (Cyp19a1) mRNA Nov 29, 2016 Dec 3, 2016
1459 1362: Increased, hippocampal hyperdepolarization 1348: Increase, seizure Apr 14, 2017 Apr 14, 2017
1549 1362: Increased, hippocampal hyperdepolarization 1344: Increased, seizure Jun 2, 2017 Jun 2, 2017
3118 2206: Increased, histomorphological alteration of testis 1758: Impaired, Spermatogenesis Jan 24, 2024 Apr 11, 2024
1068 1025: Increased, Hyperplasia (follicular cells) 1026: Increased Apoptosis, Adenomas/carcinomas (follicular cell) Nov 29, 2016 Dec 3, 2016 None
2426 1025: Increased, Hyperplasia (follicular cells) 741: Increase, Adenomas/carcinomas (follicular cell) Jul 7, 2021 Jul 7, 2021 None
1107 1069: Increased, Hyperplasia (glandular epithelial cells of endometrium) 1070: Increased, adenosquamous carcinomas of endometrium Nov 29, 2016 Dec 3, 2016 None
1123 1085: Increased, hyperplasia (mammary gland) 1080: Increased, latency period Nov 29, 2016 Dec 3, 2016
1124 1085: Increased, hyperplasia (mammary gland) 1079: Increased, Adenomas/carcinomas (mammary) Nov 29, 2016 Dec 3, 2016
1067 1024: Increased, Hypertrophy and proliferation (follicular cell) 1025: Increased, Hyperplasia (follicular cells) Nov 29, 2016 Dec 3, 2016 None
2427 1024: Increased, Hypertrophy and proliferation (follicular cell) 740: Increase, Hyperplasia (follicular cells) Jul 7, 2021 Jul 7, 2021 None
342 376: Increased, Induced Mutations in Critical Genes 377: Increased, Proliferation/Clonal Expansion of Mutant Cells (Pre-Neoplastic Lesions/Altered H Nov 29, 2016 Nov 29, 2016 None
346 376: Increased, Induced Mutations in Critical Genes 378: Tumorigenesis, Hepatocellular carcinoma Nov 29, 2016 Nov 30, 2016
351 376: Increased, Induced Mutations in Critical Genes 384: Increased, Clonal Expansion / Cell Proliferatin to form Pre-Neoplastic Altered Hepatic Foci Nov 29, 2016 Nov 29, 2016 None
549 376: Increased, Induced Mutations in Critical Genes 491: Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) Nov 29, 2016 Nov 29, 2016
891 376: Increased, Induced Mutations in Critical Genes 872: Increase, Site of Contact Nasal Tumors Nov 29, 2016 Dec 3, 2016 None
762 726: Increased, Induction of pyruvate dehydrogenase (PDH) 769: Increase, Oxidative metabolism Nov 29, 2016 Dec 3, 2016
1063 1020: Increased, induction of UDPGT's in liver 1021: Increased, T4/T3 catabolism Nov 29, 2016 Dec 3, 2016 None
1127 1087: Increased, inflammation 1032: Increased, secretion of local growth factors Nov 29, 2016 Dec 3, 2016