Key Event Relationships (KERs)

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Showing 2226 to 2250 of 3081 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
3476 2308: Increased, stimulation of brain serotonin 5-HT1a, 5-HT2c receptors 1016: Inhibition, Feeding Jan 14, 2025 Feb 20, 2025
296 366: Increased, Structural malformations 342: Increased, Lethality Nov 29, 2016 Dec 3, 2016 None
1527 1400: Increased, synaptic release 1320: Increased, extracellular serotonin Jun 1, 2017 Jun 1, 2017
1064 1021: Increased, T4/T3 catabolism 1022: Decreased, serum T4/T3 Nov 29, 2016 Dec 3, 2016 None
2423 1021: Increased, T4/T3 catabolism 281: T4 in serum, Decreased Jul 7, 2021 Jul 7, 2021 None
1066 1023: Increased, Thyroid-stimulating hormone (TSH) 1024: Increased, Hypertrophy and proliferation (follicular cell) Nov 29, 2016 Dec 3, 2016 None
2240 1023: Increased, Thyroid-stimulating hormone (TSH) 1828: Increased, Thyroxine (T4) in serum Dec 9, 2020 Dec 9, 2020
2424 1023: Increased, Thyroid-stimulating hormone (TSH) 739: Increase, Hypertrophy and proliferation (follicular cell) Jul 7, 2021 Jul 7, 2021
2425 1023: Increased, Thyroid-stimulating hormone (TSH) 753: Increase, Thyroid-stimulating hormone (TSH) Jul 7, 2021 Jul 7, 2021 None
2241 1828: Increased, Thyroxine (T4) in serum 1101: Altered, Amphibian metamorphosis Dec 9, 2020 Dec 9, 2020
2242 1828: Increased, Thyroxine (T4) in serum 1829: Altered, TH-dependent gene expression Dec 9, 2020 Dec 9, 2020
486 454: Increased, Triglyceride formation 459: Increase, Liver steatosis Nov 29, 2016 Dec 3, 2016
1201 1154: Increased, Triiodothyronine (T3) in tissues 1101: Altered, Amphibian metamorphosis Nov 29, 2016 Dec 3, 2016 None
2243 1154: Increased, Triiodothyronine (T3) in tissues 1829: Altered, TH-dependent gene expression Dec 9, 2020 Dec 9, 2020
2579 1971: tumor growth 1193: N/A, Breast Cancer Feb 15, 2022 Feb 15, 2022 None
3139 1971: tumor growth 1982: Metastasis, Breast Cancer Mar 5, 2024 Mar 5, 2024
1173 1142: Increased, valve movement 1143: Depletion, energy reserves Nov 29, 2016 Dec 3, 2016
1174 1142: Increased, valve movement 1139: Increased, water retention in foot Nov 29, 2016 Dec 3, 2016
1216 1142: Increased, valve movement 1166: Increased, water pumping Nov 29, 2016 Dec 3, 2016 None
1227 1142: Increased, valve movement 623: Increase, predation Nov 29, 2016 Dec 3, 2016
1320 1142: Increased, valve movement 1255: induced spawning Jan 13, 2017 Jan 13, 2017
1334 1142: Increased, valve movement 1257: Induced parturition Jan 30, 2017 Jan 30, 2017
571 576: Increased, Viral susceptibility 577: impaired, Development Nov 29, 2016 Dec 3, 2016
575 576: Increased, Viral susceptibility 560: Abnormal, Foraging activity and behavior Nov 29, 2016 Dec 3, 2016
1224 1166: Increased, water pumping 1139: Increased, water retention in foot Nov 29, 2016 Dec 3, 2016 None