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All KERs

Showing 1801 to 1825 of 3130 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1644	341: Impairment, Learning and memory	635: Decreased, locomotion	Aug 11, 2017	Aug 11, 2017	1 AOP 99: Histamine (H2) receptor antagonism leading to reduced survival
2872	341: Impairment, Learning and memory	2121: decreased, IQ	Apr 4, 2023	Apr 4, 2023	1 AOP 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms
125	110: Impairment, Endothelial network	298: Insufficiency, Vascular	Nov 29, 2016	Jan 18, 2022	1 AOP 43: Disruption of VEGFR Signaling Leading to Developmental Defects
976	110: Impairment, Endothelial network	317: Altered, Cardiovascular development/function	Nov 29, 2016	Jun 9, 2017	1 AOP 150: Aryl hydrocarbon receptor activation leading to early life stage mortality, via reduced VEGF
3173	2213: Impaired, urethral tube closure	2082: Hypospadias	Mar 20, 2024	Dec 3, 2024	1 AOP 527: Decreased, Chicken Ovalbumin Upstream Promoter Transcription Factor II (COUP-TFII) leads to Hypospadias, increased
665	583: impaired, Thoracic shivering	568: impaired, Hive thermoregulation	Nov 29, 2016	Dec 3, 2016	None
2164	1758: Impaired, Spermatogenesis	330: Decrease, Fertility	Jul 13, 2020	Jul 13, 2020	None
2274	1758: Impaired, Spermatogenesis	406: decreased, Fertility	Jan 29, 2021	Aug 15, 2022	1 AOP 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory
2692	1758: Impaired, Spermatogenesis	2032: Viable offspring, decreased	Jul 18, 2022	Jul 18, 2022	None
2937	1758: Impaired, Spermatogenesis	2147: Decreased, Viable Offspring	Jun 2, 2023	Sep 29, 2023	2 AOPs 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone 521: Essential element imbalance leads to reproductive failure via oxidative stress
3621	1758: Impaired, Spermatogenesis	520: Decreased sperm quantity or quality in the adult, Decreased fertility	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
3622	1758: Impaired, Spermatogenesis	1863: Decrease, Reproduction	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
2632	1989: Impaired, Oocyte maturation and ovulation	1990: Increased, Oocyte Atresia	Apr 5, 2022	Apr 5, 2022	1 AOP 445: Estrogen Receptor Alpha Agonism leads to Impaired Reproduction
3079	637: impaired, Learning and memory	896: Parkinsonian motor deficits	Oct 17, 2023	Oct 17, 2023	1 AOP 471: Neuron defect induced early behavioral change
563	566: impaired, Larval development	563: Death/Failure, Colony	Nov 29, 2016	Dec 3, 2016	4 AOPs 82: Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure 86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
3460	566: impaired, Larval development	2302: Increase, Malformations	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
701	697: impaired, ion channels	698: Altered, Action Potential	Nov 29, 2016	Dec 3, 2016	1 AOP 104: Altered ion channel activity leading impaired heart function
574	568: impaired, Hive thermoregulation	563: Death/Failure, Colony	Nov 29, 2016	Dec 3, 2016	2 AOPs 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure 80: Nicotinic acetylcholine receptor activation contributes to accumulation of damaged mitochondrial DNA and leads to colony loss/failure
1153	568: impaired, Hive thermoregulation	1107: Weakened, Colony	Nov 29, 2016	Dec 3, 2016	1 AOP 79: Nicotinic acetylcholine receptor activation contributes to impaired hive thermoregulation and leads to colony loss/failure
572	577: impaired, Development	572: Decrease, Number of worker bees	Nov 29, 2016	Dec 3, 2016	1 AOP 84: Suppression of immune system contributes to impaired development and leads to colony loss/failure
3618	2080: Impaired, blood testis barrier	520: Decreased sperm quantity or quality in the adult, Decreased fertility	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
1821	1569: Impaired T cell activation	983: Suppression, Suppression of T-cell dependent antibody response (TDAR)	Dec 25, 2018	Dec 25, 2018	None
1822	1569: Impaired T cell activation	986: Impairment of TDAR	Dec 25, 2018	Jun 1, 2019	None
1922	1569: Impaired T cell activation	1644: Impaired Ab production	May 23, 2019	Jun 25, 2019	None
3425	2287: Impaired Sodium-Calcium Exchange	389: Increased, Intracellular Calcium overload	Nov 21, 2024	Nov 21, 2024	1 AOP 556: Decreased Na/K ATPase activity leading to heart failure

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