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Showing 826 to 850 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

2787	1562: Decreased Na/K ATPase activity	1527: Increase, Cell membrane depolarization	Oct 19, 2022	Oct 19, 2022	1 AOP 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity
3287	1562: Decreased Na/K ATPase activity	2236: Decreased, sodium uptake in gills	Jul 8, 2024	Dec 3, 2024	1 AOP 539: Decreased Sodium/Potassium ATPase activity leads to Heart failure
3444	1562: Decreased Na/K ATPase activity	1321: Increased, intracellular sodium (Na+)	Nov 26, 2024	Nov 26, 2024	1 AOP 556: Decreased Na/K ATPase activity leading to heart failure
3542	2325: Decreased number of LT CD8+ cells	1971: tumor growth	Jun 10, 2025	Jun 10, 2025	None
2293	1837: decreased oocyte maturation	406: decreased, Fertility	Mar 26, 2021	Mar 26, 2021	1 AOP 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory
2278	1836: Decreased plasma Cortisol level	1837: decreased oocyte maturation	Feb 9, 2021	Feb 9, 2021	1 AOP 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory
1917	1642: plasma retinoic acid	1640: Altered, Photoreceptor patterning	May 22, 2019	May 22, 2019	1 AOP 297: Inhibition of retinaldehyde dehydrogenase leads to population decline
3111	2203: Decreased proliferation of cortical NPCs	2204: Altered brain morphology	Jan 14, 2024	Jan 14, 2024	1 AOP 520: Retinoic acid receptor agonism during neurodevelopment leading to impaired learning and memory
3125	2203: Decreased proliferation of cortical NPCs	2201: RAR agonism	Feb 2, 2024	Feb 2, 2024	None
3126	2203: Decreased proliferation of cortical NPCs	2210: Reduced cortical thickness	Feb 2, 2024	Feb 2, 2024	1 AOP 523: Retinoic acid receptor agonism during neurodevelopment leading to microcephaly
1766	1538: Protection against oxidative stress, decreased	1392: Increase, Oxidative Stress	Sep 13, 2018	Feb 7, 2020	1 AOP 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
1812	1563: Decreased proximal tubular vectorial transport	1564: Chemical induced Fanconi syndrome	Dec 20, 2018	Dec 20, 2018	1 AOP 276: Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome
1916	1641: retinoic acid	1642: plasma retinoic acid	May 22, 2019	May 22, 2019	1 AOP 297: Inhibition of retinaldehyde dehydrogenase leads to population decline
1615	1451: decreased reward	1452: decreased DNA methylation of tyrosine hydroxylase	Jul 24, 2017	Jul 24, 2017	1 AOP 72: Epigenetic modification of PPARG leading to adipogenesis
1616	1451: decreased reward	1453: decreased methylation of dopamine transporter promoter	Jul 24, 2017	Jul 24, 2017	1 AOP 72: Epigenetic modification of PPARG leading to adipogenesis
1617	1451: decreased reward	1450: decreased dopamine	Jul 24, 2017	Jul 24, 2017	1 AOP 72: Epigenetic modification of PPARG leading to adipogenesis
2611	1981: Decrease,SIRT1(sirtuin 1) levels	1172: Increased activation, Nuclear factor kappa B (NF-kB)	Mar 22, 2022	Aug 27, 2023	1 AOP 443: DNA damage and mutations leading to Metastatic Breast Cancer
1650	520: Decreased sperm quantity or quality in the adult, Decreased fertility	406: decreased, Fertility	Aug 11, 2017	Aug 11, 2017	1 AOP 64: Glucocorticoid Receptor (GR) Mediated Adult Leydig Cell Dysfunction Leading to Decreased Male Fertility
3619	520: Decreased sperm quantity or quality in the adult, Decreased fertility	1863: Decrease, Reproduction	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
2161	1798: Decreased spermatogenesis	406: decreased, Fertility	Jul 13, 2020	Jul 13, 2020	2 AOPs 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2388	1798: Decreased spermatogenesis	1696: Decrease of egg production and cummulative fecundity	May 12, 2021	May 12, 2021	1 AOP 396: Deposition of ionizing energy leads to population decline via impaired meiosis
2620	1798: Decreased spermatogenesis	328: Decrease, Fecundity	Mar 28, 2022	Mar 28, 2022	1 AOP 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2623	1798: Decreased spermatogenesis	1863: Decrease, Reproduction	Mar 28, 2022	Mar 28, 2022	1 AOP 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2624	1798: Decreased spermatogenesis	360: Decrease, Population growth rate	Mar 28, 2022	Mar 28, 2022	1 AOP 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability
2076	1756: Decreased, 11KT	1758: Impaired, Spermatogenesis	Apr 16, 2020	Apr 19, 2021	2 AOPs 323: PPARalpha Agonism Leading to Decreased Viable Offspring via Decreased 11-Ketotestosterone 348: Inhibition of 11β-Hydroxysteroid Dehydrogenase leading to decreased population trajectory

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