Key Event Relationships (KERs)

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Showing 1201 to 1225 of 3081 KERs

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ID Upstream Event Downstream Event Creation Date Last Updated AOPs
3333 2256: Activation of gluten- and TG2-reactive B cells 1931: Disruption of the intestinal barrier Aug 13, 2024 Apr 27, 2025
3336 2256: Activation of gluten- and TG2-reactive B cells 272: Activation/Proliferation, T-cells Aug 13, 2024 Aug 13, 2024 None
3345 2256: Activation of gluten- and TG2-reactive B cells 2260: Activation of gluten-reactive CD4+ T cells Sep 13, 2024 Sep 13, 2024 None
3342 2260: Activation of gluten-reactive CD4+ T cells 2256: Activation of gluten- and TG2-reactive B cells Sep 13, 2024 Feb 27, 2025
3343 2260: Activation of gluten-reactive CD4+ T cells 1931: Disruption of the intestinal barrier Sep 13, 2024 Sep 13, 2024 None
3344 2260: Activation of gluten-reactive CD4+ T cells 2252: Formation of HLA-DQ2/8-gluten complexes Sep 13, 2024 Sep 13, 2024 None
3329 2253: Generation of gluten-reactive T cell receptors 272: Activation/Proliferation, T-cells Aug 13, 2024 Aug 13, 2024 None
3339 2253: Generation of gluten-reactive T cell receptors 2260: Activation of gluten-reactive CD4+ T cells Sep 13, 2024 Sep 13, 2024 None
3385 2253: Generation of gluten-reactive T cell receptors 2275: Co-localization of gluten reactive adaptive T-cells with APC Nov 12, 2024 Apr 8, 2025
3142 1800: Reduced granulosa cell proliferation 405: disrupted, ovarian cycle Mar 7, 2024 Mar 18, 2025
1926 1647: GSK3beta inactivation 1648: β-catenin activation May 29, 2019 May 29, 2019 None
2485 1647: GSK3beta inactivation 1902: Repression of Gbx2 expression Oct 3, 2021 Dec 12, 2021
2533 1954: Gut dysbiosis 1931: Disruption of the intestinal barrier Dec 2, 2021 Dec 2, 2021 None
2544 1954: Gut dysbiosis 1497: Recruitment of inflammatory cells Dec 15, 2021 Dec 15, 2021 None
3440 2295: HCN Channel Inhibition 2296: Reduced Pacemaker Activity in SA Node Nov 24, 2024 Nov 24, 2024
2508 1535: Heart failure 1948: Upregulation of ACE2 Oct 28, 2021 Oct 28, 2021 None
2514 1535: Heart failure 1946: Altered mechanotransduction properties of pericytes Oct 28, 2021 Oct 28, 2021 None
2825 1535: Heart failure 350: Increase, Mortality Jan 5, 2023 Jan 5, 2023 None
1546 1412: Helicobacter pylori infection 1384: Increase, ammonium (NH4+) Jun 2, 2017 Jun 2, 2017
1166 1133: Hemostasis, Depletion from blood of fully functional carboxylated clotting factors 1122: Under carboxylated clotting factors will not assemble on cell surfaces to form clot, Failur Nov 29, 2016 Dec 3, 2016
1514 1393: Hepatocytotoxicity 1394: Sustained proliferation May 30, 2017 Jun 19, 2021
1517 1393: Hepatocytotoxicity 1395: Liver Cancer May 30, 2017 May 1, 2020
2535 1957: hERG channel biogenesis interference 1958: Direct hERG channel blockage Dec 13, 2021 Dec 13, 2021 None
2536 1957: hERG channel biogenesis interference 1959: Induction of hERG trafficking defects Dec 13, 2021 Dec 13, 2021 None
2850 2099: hERG channel blockade 2100: Inhibition of rapid delayed rectifying potassium current Jan 29, 2023 Jan 29, 2023