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All KERs

Showing 1801 to 1825 of 3119 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3382	1392: Increase, Oxidative Stress	1553: Increase mutations	Nov 6, 2024	Nov 6, 2024	None
3442	1392: Increase, Oxidative Stress	467: Increased, LDL uptake	Nov 25, 2024	Nov 25, 2024	1 AOP 462: Activation of reactive oxygen species leading the atherosclerosis
3602	1392: Increase, Oxidative Stress	1446: Decrease, Coupling of OXPHOS	Aug 21, 2025	Aug 21, 2025	3 AOPs 324: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and cell death 325: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell growth 326: Excessive reactive oxygen species leading to growth inhibition via uncoupling of oxidative phosphorylation and reduced cell proliferation
3616	1392: Increase, Oxidative Stress	495: Repressed expression of steroidogenic enzymes	Sep 3, 2025	Sep 3, 2025	1 AOP 595: Emerging OPFRS reproductive outcome pathway
3632	1392: Increase, Oxidative Stress	1767: Increase, Protein oxidation	Sep 8, 2025	Sep 8, 2025	5 AOPs 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 599: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and cell injury/death 600: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell growth 601: Excessive reactive oxygen species leading to growth inhibition via fatty acid oxidation and reduced cell proliferation 603: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell cycle disruption
3690	1392: Increase, Oxidative Stress	2363: Mito ROS dysfunction	Nov 7, 2025	Nov 7, 2025	1 AOP 616: organic UV filter and its Photoproducts reproductive toxicity pathways
1362	1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK	1281: Increased, DNA Damage-Repair	Feb 15, 2017	Feb 15, 2017	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
1364	1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK	1280: Activation, HIF-1	Feb 15, 2017	Feb 15, 2017	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
3166	1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK	177: Increase, Mitochondrial dysfunction	Mar 14, 2024	Mar 14, 2024	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
3512	1279: Increase, Oxidative Stress / Activation, PMK-1 P38 MAPK	1115: Increase, ROS	Apr 3, 2025	Apr 3, 2025	1 AOP 207: NADPH oxidase and P38 MAPK activation leading to reproductive failure in Caenorhabditis elegans
2340	1865: Increase, OEC damage	1862: Decrease, Photosystem II efficiency	Apr 11, 2021	Apr 11, 2021	1 AOP 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis
3552	2337: Increase, PLIN2	2333: Increase, Fat mass	Jul 25, 2025	Jul 25, 2025	1 AOP 580: Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index
1241	1173: Increase, Peroxisomal Fatty Acid Beta Oxidation of Fatty Acids	209: Peptide Oxidation	Nov 29, 2016	Dec 3, 2016	None
1230	1170: Increase, Phenotypic enzyme activity	716: Increase, cell proliferation (hepatocytes)	Nov 29, 2016	Dec 31, 2020	1 AOP 37: PPARα activation leading to hepatocellular adenomas and carcinomas in rodents
1231	1170: Increase, Phenotypic enzyme activity	1171: Increase, Clonal Expansion of Altered Hepatic Foci	Nov 29, 2016	Dec 3, 2016	None
2409	1892: increase, placental insufficiency	1893: increase, Preeclampsia	May 31, 2021	May 31, 2021	1 AOP 151: AhR activation leading to preeclampsia
254	220: Increase, Plasma vitellogenin concentrations	252: Increase, Renal pathology due to VTG deposition	Nov 29, 2016	Jun 24, 2024	2 AOPs 29: Estrogen receptor agonism leading to reproductive dysfunction 536: Estrogen receptor agonism leading to reduced survival and population growth due to renal failure
3259	220: Increase, Plasma vitellogenin concentrations	364: Impaired development of, Reproductive organs	Jul 3, 2024	Jul 3, 2024	1 AOP 537: Estrogen receptor agonism leads to reduced fecundity via increased vitellogenin in the liver
1474	1375: Increase, platelet aggregation	1367: Inhibit, gastric ulcer formation	Apr 17, 2017	Apr 17, 2017	1 AOP 217: Gastric ulcer formation
2555	1965: Increase, Pollen abnormal	1863: Decrease, Reproduction	Jan 21, 2022	Jan 21, 2022	1 AOP 435: Deposition of ionising energy leads to population decline via pollen abnormal
2070	1754: Increase, porcupine-induced Wnt secretion and Wnt signaling activation	1755: beta-catenin activation	Mar 23, 2020	Nov 9, 2021	1 AOP 298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
2634	623: Increase, predation	360: Decrease, Population growth rate	Apr 6, 2022	Apr 6, 2022	1 AOP 97: 5-hydroxytryptamine transporter (5-HTT; SERT) inhibition leading to population decline
1744	1524: Increase, Premature molting	350: Increase, Mortality	May 24, 2018	Feb 17, 2021	5 AOPs 358: Chitinase inhibition leading to mortality 359: Chitobiase inhibition leading to mortality 360: Chitin synthase 1 inhibition leading to mortality 361: Sulfonylureareceptor binding leading to mortality 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
774	774: Increase, Preneoplastic foci (hepatocytes)	719: Increase, hepatocellular adenomas and carcinomas	Nov 29, 2016	Feb 15, 2017	3 AOPs 107: Constitutive androstane receptor activation leading to hepatocellular adenomas and carcinomas in the mouse and the rat 117: Androgen receptor activation leading to hepatocellular adenomas and carcinomas (in mouse and rat) 118: Chronic cytotoxicity leading to hepatocellular adenomas and carcinomas (in mouse and rat)
2835	2097: Increase, Pro-Inflammatory Mediators	2098: Abnormal Neural Remodeling	Jan 25, 2023	Sep 10, 2024	1 AOP 483: Deposition of Energy Leading to Learning and Memory Impairment

Key Event Relationships (KERs)

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