Prototypical Stressors

Showing 451 to 475 of 853 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

161	Levothyroxine	Levothyroxine, CAS-RN: 51-48-9, DTXSID8023214	None
694	Liarozole	Liarozole, CAS-RN: 115575-11-6, DTXSID9048277	None
483	LiCl		None
99	Lidocaine	Lidocaine, CAS-RN: 137-58-6, DTXSID1045166	553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure
415	Light (290-700 nm)		282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
112	Lindane	Lindane, CAS-RN: 58-89-9, DTXSID2020686	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
564	Linuron	Linuron, CAS-RN: 330-55-2, DTXSID2024163	None
376	Lipopolysaccharride	Lipopolysaccharride, CAS-RN: NOCAS, DTXSID4036695	237: Substance interaction with lung resident cell membrane components leading to atherosclerosis
551	Losartan	Losartan, CAS-RN: 114798-26-4, DTXSID7023227	319: Binding to ACE2 leading to lung fibrosis
779	lotenone		475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
502	Low LET Radiation		None
334	low molecular weight proteins		257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
374	LPS		None
575	Lysodren, Mitotan, Mitotane	Lysodren, Mitotan, Mitotane, CAS-RN: 164203-73-0, DTXSID30425146	349: Inhibition of 11β-hydroxylase leading to decresed population trajectory
245	Makisterone A		4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1
546	Malathion	Malathion, CAS-RN: 121-75-5, DTXSID4020791	2 AOPs 551: Increased Muscarinic M2 Receptor leading to Arrhythmia 559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
606	Malonoben	Malonoben, CAS-RN: 10537-47-0, DTXSID1042106	None
314	Mancozeb	Mancozeb, CAS-RN: 8018-01-7, DTXSID0034695	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
33	Maneb	Maneb, CAS-RN: 12427-38-2, DTXSID9020794	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
721	Manganese	Manganese, CAS-RN: 7439-96-5, DTXSID2024169	2 AOPs 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
263	Meclofenamic acid	Meclofenamic acid, CAS-RN: 644-62-2, DTXSID0048559	152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
679	Meconium		None
189	Mefenamic acid	Mefenamic acid, CAS-RN: 61-68-7, DTXSID5023243	None
192	Meloxicam	Meloxicam, CAS-RN: 71125-38-7, DTXSID1020803	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
271	Mental stress		403: combined unhealthy lifestyle factors leading to metabolic syndrome