Prototypical Stressors

Showing 451 to 475 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

811	Ivabradine		2 AOPs 560: Inhibition of Funny current (If) leading to Arrhythmias 562: HCN Channel Inhibition leading to Arrhythmias
531	Kaempferol	Kaempferol, CAS-RN: 520-18-3, DTXSID7020768	154: Inhibition of Calcineurin Activity Leading to Impaired T-Cell Dependent Antibody Response
29	Kainic acid	Kainic acid, CAS-RN: 487-79-6, DTXSID7040526	None
397	KCN	Potassium cyanide, CAS-RN: 151-50-8, DTXSID0024268	None
475	Kenpaullone		None
282	Ketoconazole	Ketoconazole, CAS-RN: 65277-42-1, DTXSID7029879	4 AOPs 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior 349: Inhibition of 11β-hydroxylase leading to decresed population trajectory 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
181	Ketoprofen	Ketoprofen, CAS-RN: 22071-15-4, DTXSID6020771	177: Cyclooxygenase 1 (COX1) inhibition leading to renal failure and mortality
186	Ketorolac Tromethamine	Ketorolac tromethamine, CAS-RN: 74103-07-4, DTXSID0045597	None
217	kinoprene	Kinoprene, CAS-RN: 42588-37-4, DTXSID3032624	201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
109	Lambda-Cyhalothrin	λ-Cyhalothrin, CAS-RN: 91465-08-6, DTXSID7032559	None
59	Lead	Lead, CAS-RN: 7439-92-1, DTXSID2024161	8 AOPs 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP) 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure 556: Decreased Na/K ATPase activity leading to heart failure 558: Phosphodiesterase inhibition leading to heart failure 560: Inhibition of Funny current (If) leading to Arrhythmias
30	Lead(II)		None
31	Lead(II) acetate trihydrate	Lead(II) acetate trihydrate, CAS-RN: 6080-56-4, DTXSID3031521	None
760	Lei Gong Teng (Common Threewingnut Root)		486: Binding to the extracellular protein laminin leading to decreased cognitive function
32	Letrozole	Letrozole, CAS-RN: 112809-51-5, DTXSID4023202 Fadrozole, CAS-RN: 102676-47-1, DTXSID5034141	2 AOPs 153: Aromatase Inhibition leading to Ovulation Inhibition and Decreased Fertility in Female Rats 346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
161	Levothyroxine	Levothyroxine, CAS-RN: 51-48-9, DTXSID8023214	None
694	Liarozole	Liarozole, CAS-RN: 115575-11-6, DTXSID9048277	None
483	LiCl		None
99	Lidocaine	Lidocaine, CAS-RN: 137-58-6, DTXSID1045166	553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure
415	Light (290-700 nm)		282: Adverse outcome pathway on photochemical toxicity initiated by light exposure
112	Lindane	Lindane, CAS-RN: 58-89-9, DTXSID2020686	10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
564	Linuron	Linuron, CAS-RN: 330-55-2, DTXSID2024163	619: Androgen receptor antagonism leads to delayed preputial separation via reduced fibroblast growth factor in genital-tubercle tissues
376	Lipopolysaccharride	Lipopolysaccharride, CAS-RN: NOCAS, DTXSID4036695	237: Substance interaction with lung resident cell membrane components leading to atherosclerosis via acute phase response
551	Losartan	Losartan, CAS-RN: 114798-26-4, DTXSID7023227	319: Binding to ACE2 leading to lung fibrosis
779	lotenone		475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons