Prototypical Stressors

Showing 651 to 675 of 871 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

772	PPAR agonist		529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
300	PPARalpha antagonists		2 AOPs 6: Antagonist binding to PPARα leading to body-weight loss 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
611	Pralnacasan (VX-740, HMR3480)		277: Impaired IL-1R1 signaling leading to Impaired T-Cell Dependent Antibody Response
608	Pralnacasan (VX-740)		None
487	Pralnacasan (VX-740) and Belnacasan (VX-765)		None
764	Preferred: Altered Gravity		None
702	Probucol	Probucol, CAS-RN: 23288-49-5, DTXSID2045440	None
705	Procainamide	Procainamide, CAS-RN: 51-06-9, DTXSID7023512	None
47	Prochloraz	Prochloraz, CAS-RN: 67747-09-5, DTXSID4024270	346: Aromatase inhibition leads to male-biased sex ratio via impacts on gonad differentiation
565	Procymidone	Procymidone, CAS-RN: 32809-16-8, DTXSID9033923	3 AOPs 344: Androgen receptor (AR) antagonism leading to nipple retention (NR) in male (mammalian) offspring 477: Androgen receptor (AR) antagonism leading to hypospadias in male (mammalian) offspring 619: Androgen receptor antagonism leads to delayed preputial separation via reduced fibroblast growth factor in genital-tubercle tissues
505	Progesterone,estrogen,melatonin,Letrozole		309: Luteinizing hormone receptor antagonism leading to reproductive dysfunction
287	Propiconazole	Propiconazole, CAS-RN: 60207-90-1, DTXSID8024280	None
155	Propyl Acetate	Propyl acetate, CAS-RN: 109-60-4, DTXSID6021901	None
139	Propylene oxide		None
582	Propylpyrazoletriol		None
48	Propylthiouracil	6-Propyl-2-thiouracil, CAS-RN: 51-52-5, DTXSID5021209	5 AOPs 175: Thyroperoxidase inhibition leading to altered amphibian metamorphosis 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 271: Inhibition of thyroid peroxidase leading to impaired fertility in fish 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure
681	Prototypical stressor		211: Handbook development AOP
445	Psammaplin A		2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
541	psychosocial stress		403: combined unhealthy lifestyle factors leading to metabolic syndrome
862	Pyrene	Pyrene, CAS-RN: 129-00-0, DTXSID3024289	3 AOPs 644: Bulky DNA adducts leading to chromosomal aberrations and mutations 645: Binding and activation of AhR lead to cardiovascular aging 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
171	Pyrethrins and Pyrethroids		3 AOPs 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 442: Binding to voltage gate sodium channels during development leads to cognitive impairment 553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure
419	Pyridaben	Pyridaben, CAS-RN: 96489-71-3, DTXSID5032573	None
815	Pyridostigmine		559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
851	Pyrimidifen	Pyrimidifen, CAS-RN: 105779-78-0, DTXSID9057925	3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
215	pyriproxyfen	Pyriproxyfen, CAS-RN: 95737-68-1, DTXSID1032640	201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline