Prototypical Stressors

Showing 651 to 675 of 853 Prototypical Stressors

ID	Prototypical Stressor Name	Associated Chemical(s): Name, CAS-RN, DTXSID	Associated AOPs

445	Psammaplin A		2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
541	psychosocial stress		403: combined unhealthy lifestyle factors leading to metabolic syndrome
171	Pyrethrins and Pyrethroids		3 AOPs 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse 442: Binding to voltage gate sodium channels during development leads to cognitive impairment 553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure
419	Pyridaben	Pyridaben, CAS-RN: 96489-71-3, DTXSID5032573	None
815	Pyridostigmine		559: Inhibition of acetylcholinesterase (AChE) leading to arrhythmias
851	Pyrimidifen	Pyrimidifen, CAS-RN: 105779-78-0, DTXSID9057925	3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits
215	pyriproxyfen	Pyriproxyfen, CAS-RN: 95737-68-1, DTXSID1032640	201: Juvenile hormone receptor agonism leading to male offspring induction associated population decline
313	Pyrolidine dithiocarbamate		242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
703	Quinidine	Quinidine, CAS-RN: 56-54-2, DTXSID4023549	None
542	Radiation		None
460	Radiomimetic compounds		None
173	Raloxifene	Raloxifene, CAS-RN: 84449-90-1, DTXSID3023550	2 AOPs 165: Antiestrogen activity leading to ovarian adenomas and granular cell tumors in the mouse 440: Hypothalamus estrogen receptors activity suppression leading to ovarian cancer via ovarian epithelial cell hyperplasia
586	RB1		315: Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
113	RDX		10: Binding to the picrotoxin site of ionotropic GABA receptors leading to epileptic seizures in adult brain
303	Reactive oxygen species		5 AOPs 148: EGFR Activation Leading to Decreased Lung Function 149: Peptide Oxidation Leading to Hypertension 282: Adverse outcome pathway on photochemical toxicity initiated by light exposure 296: Oxidative DNA damage leading to chromosomal aberrations and mutations 462: Activation of reactive oxygen species leading the atherosclerosis
840	Redox status		504: SULT1E1 inhibition leading to uterine adenocarcinoma via increased estrogen availability at target organ level
693	Repaglinide	Repaglinide, CAS-RN: 135062-02-1, DTXSID3023552	None
179	Reserpine	Reserpine, CAS-RN: 50-55-5, DTXSID7021237	170: Anti-dopaminergic activity leading to mammary adenomas and carcinomas in the SD rat
520	Resiquimod	Resiquimod, CAS-RN: 144875-48-9, DTXSID7040603	313: Stimulation of TLR7/8 in dendric cells leading to Psoriatic skin disease
49	Resorcinol	Resorcinol, CAS-RN: 108-46-3, DTXSID2021238 Tetraphenyl m-phenylene bis(phosphate), CAS-RN: 57583-54-7, DTXSID8069197	None
652	Retinoic acid		None
60	Retinol	Retinol, CAS-RN: 68-26-8, DTXSID3023556	38: Protein Alkylation leading to Liver Fibrosis
448	RG 108		2 AOPs 290: Mitochondrial ATP synthase antagonism leading to growth inhibition (1) 291: Mitochondrial ATP synthase antagonism leading to growth inhibition (2)
248	RH-5849		2 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade
644	Rocilinostat / Ricolinostat		None