AOPs

OECD View API
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Showing 576 to 589 of 589 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
637 Activation, estrogen receptor alpha leads to increased uterine weight via earlier proliferation of cells of the uterine lining John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2413: Increased, uterine weight
638 Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis Wei Mu BY-SA
639 Activation, estrogen receptor alpha leads to precocious puberty via increased kisspeptin release John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2415: Precocious puberty
640 Activation, estrogen receptor alpha leads to decreased fertility via prolonged estrus cycle John Frisch BY-SA 1065: Activation, estrogen receptor alpha 406: decreased, Fertility
641 Activation, estrogen receptor alpha leads to increased, phenotypic female-biased sex ratio via increased, differentiation to ovaries John Frisch BY-SA 1065: Activation, estrogen receptor alpha 2418: Increased, phenotypic female-biased sex ratio
642 Intestinal FXR inhibition leading to steatohepatitis via gut‑liver axis dysregulation Jung-Hwa Oh BY-SA 2421: Inhibition, Intestinal FXR 1489: Increase, Steatohepatitis
644 Bulky DNA adducts leading to chromosomal aberrations and mutations Beckner Andersano BY-SA 1879: Bulky DNA adducts, increase
645 Binding and activation of AhR lead to cardiovascular aging Shiheng Gui BY-SA 2430: Aryl hydrocarbon receptor（AhR）activation 2438: Increase, Cardiovascular aging
646 Binding and activation of AhR/PPARγ lead to lipid metabolism disorders Shiheng Gui BY-SA 1995: Abnormal lipid metabolism
647 Keap1 cysteine modification induced by nanoparticles leading to growth impairment and neurobehavioral decline via dysregulation of Nrf2-mediated antioxidant responses Ying Wang All rights reserved 1115: Increase, Reactive oxygen species None
648 Nanomaterial-induced ferritinophagy activation leading to Parkinson's-like motor dysfunction via iron-dependent ferroptotic neurodegeneration Ying Wang All rights reserved None None
649 Photocatalytic ROS generation by titanium dioxide nanoparticles leading to visual dysfunction and reduced larval survival via retinal photoreceptor oxidative damage Ying Wang All rights reserved None None
650 Polystyrene nanoplastic-induced PPAR signaling dysregulation leading to hepatic steatosis and metabolic dysfunction via oxidative stress-driven lipid metabolism reprogramming Ying Wang All rights reserved None None
651 Suppression, Estrogen receptor (ER) activity leads to Impaired, Spermatogenesis via epigenetic modifications John Frisch BY-SA 1046: Suppression, Estrogen receptor (ER) activity 1758: Impaired, Spermatogenesis