AOPs

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Showing 51 to 75 of 578 AOPs

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ID Title Point of Contact License MIE AO OECD Status OECD Project
589 Inhibition of the mitochondrial complex IV of nigro-striatal neurons leads to parkinsonian motor deficits Barbara Viviani BY-SA 1543: Mitochondrial Complex IV inhibition 896: Parkinsonian motor deficits
588 Inhibition of the mitochondrial complex II of nigro-striatal neurons leads to parkinsonian motor deficits Barbara Viviani BY-SA 2118: Succinate dehydrogenase, inhibited 896: Parkinsonian motor deficits
587 Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits Barbara Viviani BY-SA 1542: Inhibition, Mitochondrial complex III 896: Parkinsonian motor deficits
586 The increasing accumulation of HMGB1 in the nucleus causes cardiomyocyte death via HMGB1/HSPB1/CCN2 pathway Peihua Luo All rights reserved None None
585 AKT Inhibition blocks the autophagy flow through the PRKAA/AMPK pathway and leads to cardiotoxicity Peihua Luo All rights reserved None None
584 SQLE accumulation leads to hepatotoxicity via cholesterol/sphingolipid metabolic disturbance and lysosomal damage Peihua Luo All rights reserved None None
583 Vascular endothelial HER2 inhibition disrupts cardiomyocyte calcium homeostasis via EGFR/STAT3/PTX3 axis leading to cardiac contractile dysfunction Peihua Luo All rights reserved None None
582 Inhibition of EphA2 phosphorylation leads to liver damage via the ERK/ MDM2/p53 axis Peihua Luo All rights reserved None None
581 Glucocorticoid receptor (GR) activation during development leads to cognitive function (COG) decrease Marie-Gabrielle Zurich All rights reserved 122: Increase, Glucocorticoid receptor activation 402: Cognitive function, decreased
580 Mineralocorticoid Receptor Activation Leading to Increased Body Mass Index Théo Jamay All rights reserved 2331: Activation, Mineralocorticoid Receptor 2335: Increase, body mass index
579 Transthyretin disruption in developing fish leading to projected decline in fish population Adriana Webb BY-SA None None
578 AhR activation leading to cancer progression via immunosuppression Léo SPORTES-MILOT BY-SA 18: Activation, AhR 1971: Increased, tumor growth
577 AhR activation leading to endometriosis Léna CAUDAL BY-SA 18: Activation, AhR None
576 5α-reductase inhibition leading to increased nipple retention (NR) in male (rodent) offspring Terje Svingen BY-SA 1617: Inhibition, 5α-reductase 1786: Nipple retention (NR), increased
575 Decreased testosterone synthesis leading to increased nipple retention (NR) in male (rodent) offspring Terje Svingen BY-SA None 1786: Nipple retention (NR), increased
574 Inhibition, cytochrome oxidase leads to Loss of olfactory function John Frisch BY-SA 1840: Inhibition, cytochrome oxidase 2317: Loss of olfactory function
573 Inhibition, cytochrome oxidase leads to Increased, pulmonary edema John Frisch BY-SA 1840: Inhibition, cytochrome oxidase 2316: Increased, pulmonary edema
572 BMP4 Suppression Disrupting Cytoskeletal Remodeling Leading to Neural Tube Closure Defects Job Berkhout All rights reserved None None
571 5α-reductase inhibition leading to hypospadias in male (mammalian) offspring Terje Svingen BY-SA 1617: Inhibition, 5α-reductase 2082: Hypospadias, increased
570 Decreased testosterone synthesis leading to hypospadias in male (mammalian) offspring Terje Svingen BY-SA None 2082: Hypospadias, increased
569 Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway Huimin Ma All rights reserved 2309: Decreased DNA methylation of FAM50B/PTCHD3 2121: decreased, Intellectual Quotient
568 Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding John Frisch BY-SA 619: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) 1016: Inhibition, Feeding
567 Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition Li Xie BY-SA 2307: Binding of plastoquinone B (QB) within D1 protein of Photosystem II 360: Decrease, Population growth rate
566 Decreased, GnRH pulsatility/release leading to estradiol availability, increased via impaired ovulation Martina Panzarea All rights reserved None 2306: Persistent vaginal cornification
565 17β-Hydroxysteroid dehydrogenase 2, inhibition leading to activation, estrogen receptor alpha Martina Panzarea All rights reserved 2250: 17β-Hydroxysteroid dehydrogenase 2, inhibition None