AOP-Wiki

API

All Key Events

Showing 551 to 575 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

985	Relief, Relief of atopic dermatitis Short Name Relief, Relief of atopic dermatitis	0	Individual	Nov 29, 2016	Dec 3, 2016	None
986	Impairment of TDAR Short Name Impairment of TDAR	0	Individual	Nov 29, 2016	Mar 2, 2023	None
987	Metaplasia of goblet cells Short Name Metaplasia of goblet cells	0	Molecular	Nov 29, 2016	Oct 5, 2020	None
988	Decrease, Circulating ecdysis triggering hormone Short Name Decrease, Circulating ETH	1	Tissue	Nov 29, 2016	May 24, 2018	3 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
989	Decreased, synthesis and secretion of molting fluid proteases Short Name	0		Nov 29, 2016	Nov 29, 2016	None
990	Increase, Incomplete ecdysis Short Name Increase, Incomplete ecdysis	1	Individual	Nov 29, 2016	May 24, 2018	5 AOPs 466: Doda decarboxylase leading to mortality 467: Knickkopf leading to mortality 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
992	Decreased, Population 2 Short Name Decreased, Population 2	0		Nov 29, 2016	Nov 29, 2016	None
993	Decrease, Abdominal muscle contraction Short Name Decrease, Abdominal muscle contraction	1	Tissue	Nov 29, 2016	May 24, 2018	3 AOPs 4: Ecdysone receptor agonism leading to mortality via suppression of Ftz-f1 342: Ecdysone receptor hyperactivation leading to mortality via mis-timed activation of nuclear receptor cascade 343: Ecdysone receptor antagonism leading to mortality via mis-timed ecdysone receptor-responsive nuclear receptor cascade
994	Decreased, Synthesis of molting fluid proteases Short Name	0	Tissue	Nov 29, 2016	Dec 3, 2016	None
996	Decrease, Digestion of old cuticle Short Name Decrease, Digestion of old cuticle	0	Organ	Nov 29, 2016	Oct 21, 2020	2 AOPs 358: Chitinase inhibition leading to mortality 359: Chitobiase inhibition leading to mortality
997	Decreased, Population size Short Name Decreased, Population size	0	Population	Nov 29, 2016	Dec 3, 2016	396: Deposition of ionizing energy leads to population decline via impaired meiosis
998	Binding of antagonist, PPAR alpha Short Name Binding of antagonist, PPAR alpha	1	Molecular	Nov 29, 2016	Sep 16, 2017	6: Antagonist binding to PPARα leading to body-weight loss
999	stabilization, co-repressor Short Name stabilization, co-repressor	0		Nov 29, 2016	Nov 29, 2016	None
1000	stabilization, PPAR alpha co-repressor Short Name stabilization, PPAR alpha co-repressor	2	Molecular	Nov 29, 2016	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
1001	Increased, Developmental Defects Short Name Increased, Developmental Defects	1	Molecular	Nov 29, 2016	Aug 31, 2023	43: Disruption of VEGFR Signaling Leading to Developmental Defects
1002	Inhibition, Deiodinase 2 Short Name Inhibition, Deiodinase 2	1	Molecular	Nov 29, 2016	Nov 19, 2025	4 AOPs 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 190: Type II iodothyronine deiodinase (DIO2) inhibition leading to altered amphibian metamorphosis 610: Decreased thyroid hormone levels in the brain regulated via transport, metabolism and TR activation leading to decreased cognition and motor function
1003	Decreased, Triiodothyronine (T3) Short Name Decreased, Triiodothyronine (T3)	1	Tissue	Nov 29, 2016	Oct 7, 2022	10 AOPs 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 189: Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 363: Thyroperoxidase inhibition leading to altered visual function via altered retinal layer structure 364: Thyroperoxidase inhibition leading to altered visual function via decreased eye size 365: Thyroperoxidase inhibition leading to altered visual function via altered photoreceptor patterning 605: Thyroid Peroxidase Inhibition Leading to Reduced, Swimming Performance via Hypomyelination
1004	Reduced, Posterior swim bladder inflation Short Name	1	Organ	Nov 29, 2016	Oct 7, 2022	2 AOPs 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation
1005	Reduced, Swimming performance Short Name Reduced, Swimming performance	1	Individual	Nov 29, 2016	Sep 8, 2021	10 AOPs 155: Deiodinase 2 inhibition leading to increased mortality via reduced posterior swim bladder inflation 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity 334: Glucocorticoid Receptor Agonism Leading to Impaired Fin Regeneration 605: Thyroid Peroxidase Inhibition Leading to Reduced, Swimming Performance via Hypomyelination 608: Thyroid Hormone Excess Leading to Reduced, Swimming Performance via Hypomyelination 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
1007	Reduced, Anterior swim bladder inflation Short Name	1	Organ	Nov 29, 2016	Oct 7, 2022	3 AOPs 156: Deiodinase 2 inhibition leading to increased mortality via reduced anterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 159: Thyroperoxidase inhibition leading to increased mortality via reduced anterior swim bladder inflation
1008	Reduced, Hearing Short Name Reduced, Hearing	1	Organ	Nov 29, 2016	Feb 18, 2019	410: GSK3beta inactivation leading to increased mortality via defects in developing inner ear
1009	Inhibition, Deiodinase 1 Short Name Inhibition, Deiodinase 1	1	Molecular	Nov 29, 2016	Nov 18, 2025	3 AOPs 157: Deiodinase 1 inhibition leading to increased mortality via reduced posterior swim bladder inflation 158: Deiodinase 1 inhibition leading to increased mortality via reduced anterior swim bladder inflation 189: Type I iodothyronine deiodinase (DIO1) inhibition leading to altered amphibian metamorphosis
1011	Increased, Chloride influx Short Name Increased, Chloride influx	0		Nov 29, 2016	Nov 29, 2016	None
1012	Increased, Inhibitory postsynaptic potential Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 160: Ionotropic gamma-aminobutyric acid receptor activation mediated neurotransmission inhibition leading to mortality 161: Glutamate-gated chloride channel activation leading to neurotransmission inhibition associated mortality 471: Neuron defect induced early behavioral change
1013	Inhibition, Motor neuron activity Short Name Inhibition, Motor neuron activity	0		Nov 29, 2016	Nov 29, 2016	None