AOP-Wiki

API

All Key Events

Showing 851 to 875 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1300	Activation, mTORC1 Short Name Activation, mTORC1	0	Molecular	Apr 12, 2017	Apr 12, 2017	401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
1301	Activation, SREBP-1 Short Name Activation, SREBP-1	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1302	Activation, L-FABP Short Name Activation, L-FABP	0	Molecular	Apr 12, 2017	Apr 13, 2017	None
1303	Activation, HSD17B4 Short Name Activation, HSD17B4	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1304	Activation, FXR Short Name Activation, FXR	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1305	Increase, cytosolic fatty acid Short Name Increase, cytosolic fatty acid	0	Cellular	Apr 12, 2017	Nov 27, 2017	213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
1306	Increase, De novo lipogenesis Short Name Increase, De novo lipogenesis	0	Cellular	Apr 12, 2017	Feb 10, 2026	3 AOPs 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
1307	Inhibition, LXR Short Name Inhibition, LXR	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1308	Inhibition, LRH-1 Short Name Inhibition, LRH-1	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1309	Activation, aPKC Short Name Activation, aPKC	0	Molecular	Apr 13, 2017	Apr 13, 2017	None
1310	Activation, PI3K Short Name Activation, PI3K	0	Molecular	Apr 13, 2017	Apr 13, 2017	401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
1312	Increase, Fatty acid beta-oxidation Short Name Increase, Fatty acid β-oxidation	0	Cellular	Apr 13, 2017	Dec 4, 2020	2 AOPs 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production
1313	Decrease, cytosolic fatty acid Short Name Decrease, cytosolic fatty acid	0	Molecular	Apr 13, 2017	Apr 13, 2017	None
1314	Activation, LRH-1 Short Name Activation, LRH-1	0	Molecular	Apr 13, 2017	Apr 13, 2017	None
1315	Increase, Selective Serotonin Reuptake Inhibitors (SSRIs) Short Name Increase, SSRIs	0	Molecular	Apr 13, 2017	Apr 13, 2017	None
1316	Inhibit, serotonin transporter activity Short Name Inhibit, serotonin transporter activity	0	Molecular	Apr 13, 2017	Apr 13, 2017	214: Network of SSRIs (selective serotonin reuptake inhibitors)
1317	Decreased, serotonin transporter activity Short Name	0	Molecular	Apr 13, 2017	May 31, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1318	Decreased, extracellular sodium (Na+) Short Name Decreased, extracellular Na+	0	Molecular	Apr 13, 2017	Apr 13, 2017	214: Network of SSRIs (selective serotonin reuptake inhibitors)
1319	Decreased, extracellular chloride (Cl-) Short Name Decreased, extracellular chloride (Cl-)	0	Molecular	Apr 13, 2017	Apr 13, 2017	214: Network of SSRIs (selective serotonin reuptake inhibitors)
1320	Increased, extracellular serotonin Short Name Increased, extracellular serotonin	2	Molecular	Apr 13, 2017	Feb 13, 2025	8 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 223: Serotonin transporter activation to seizure 224: Serotonin transporter activation to depression 225: Serotonin transporter activation to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension 568: Inhibition, 5-hydroxytryptamine transporter (5-HTT; SERT) leads to Inhibition, Feeding
1321	Increased, intracellular sodium (Na+) Short Name Increased, intracellular sodium (Na+)	0	Molecular	Apr 13, 2017	Apr 13, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 556: Decreased Na/K ATPase activity leading to heart failure
1322	Increased, intracellular chloride (Cl-) Short Name Increased, intracellular chloride (Cl-)	0	Molecular	Apr 13, 2017	Apr 13, 2017	2 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 215: Molecular events lead to epilepsy
1323	Decreased, intracellular serotonin Short Name Decreased, intracellular serotonin	0	Molecular	Apr 13, 2017	May 31, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1324	Decreased, packaged serotonin Short Name Decreased, packaged serotonin	0	Molecular	Apr 13, 2017	May 31, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension
1325	Decreased, synaptic release Short Name Decreased, synaptic release	0	Molecular	Apr 13, 2017	May 31, 2017	4 AOPs 214: Network of SSRIs (selective serotonin reuptake inhibitors) 221: Mental stress to depression 222: Mental stress to agitation 226: SSRI (Selective serotonin reuptake inhibitor) to hypertension