AOP-Wiki

API

All Key Events

Showing 901 to 925 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1351	Activated, NMDA receptor Short Name Activated, NMDA receptor	0	Molecular	Apr 14, 2017	Jun 2, 2017	2 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy
1352	Activated, voltage-gated sodium channel Short Name Activated, voltage-gated sodium channel	0	Molecular	Apr 14, 2017	Jun 2, 2017	2 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy
1353	Binding to voltage-gated sodium channel Short Name Binding to VGSC	1	Molecular	Apr 14, 2017	Jul 31, 2024	4 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 442: Binding to voltage gate sodium channels during development leads to cognitive impairment 489: Inhibition of voltage-gated sodium channels leading to decreased cognition
1354	Treat, carbamazepine Short Name Treat, carbamazepine	0	Molecular	Apr 14, 2017	Apr 14, 2017	2 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy
1355	Activated, membrane depolarization Short Name Activated, membrane depolarization	0	Cellular	Apr 14, 2017	Jun 2, 2017	3 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 231: presynaptic neuron 2 repression to epilepsy
1356	Inactive, membrane depolarization Short Name Inactive, membrane depolarization	0	Molecular	Apr 14, 2017	Apr 14, 2017	215: Molecular events lead to epilepsy
1357	Increased, RDX dose Short Name Increased, RDX dose	0	Molecular	Apr 14, 2017	Jun 2, 2017	2 AOPs 215: Molecular events lead to epilepsy 231: presynaptic neuron 2 repression to epilepsy
1358	Repress, GABA-A receptor Short Name Repress, GABA-A receptor	0	Molecular	Apr 14, 2017	Apr 14, 2017	215: Molecular events lead to epilepsy
1359	Activate, GABA-A receptor Short Name Activate, GABA-A receptor	0	Molecular	Apr 14, 2017	Apr 14, 2017	215: Molecular events lead to epilepsy
1360	Activate, presynaptic neuron 2 Short Name Activate, presynaptic neuron 2	0	Molecular	Apr 14, 2017	Apr 14, 2017	215: Molecular events lead to epilepsy
1361	Increase, GABA Short Name Increase, GABA	0	Molecular	Apr 14, 2017	Apr 14, 2017	215: Molecular events lead to epilepsy
1362	Increased, hippocampal hyperdepolarization Short Name	0	Molecular	Apr 14, 2017	Jun 2, 2017	3 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 231: presynaptic neuron 2 repression to epilepsy
1363	Increased, epilepsy Short Name Increased, epilepsy	0	Individual	Apr 14, 2017	Jun 2, 2017	4 AOPs 215: Molecular events lead to epilepsy 230: presynaptic neuron 1 activation to epilepsy 231: presynaptic neuron 2 repression to epilepsy 471: Neuron defect induced early behavioral change
1365	Increase, Apoptosis Short Name Increase, Apoptosis	0	Cellular	Apr 15, 2017	Apr 15, 2017	6 AOPs 322: Alkylation of DNA leading to reduced sperm count 444: Ionizing radiation leads to reduced reproduction in Eisenia fetida via reduced spermatogenesis and cocoon hatchability 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways 509: Nrf2 inhibition leading to vascular disrupting effects through activating apoptosis signal pathway and mitochondrial dysfunction 330: Excessive reactive oxygen species production leading to mortality (4) 622: Calcineurin inhibitor induced nephrotoxicity leading to kidney failure
1366	Decrease, Oogenesis Short Name Decrease, Oogenesis	0	Organ	Apr 15, 2017	Apr 30, 2020	9 AOPs 336: DNA methyltransferase inhibition leading to population decline (1) 337: DNA methyltransferase inhibition leading to population decline (2) 338: DNA methyltransferase inhibition leading to population decline (3) 339: DNA methyltransferase inhibition leading to population decline (4) 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 238: Deposition of energy leading to population decline via DNA strand breaks and oocyte apoptosis 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia 311: Deposition of energy leading to population decline via DNA oxidation and oocyte apoptosis 396: Deposition of ionizing energy leads to population decline via impaired meiosis
1367	Inhibit, gastric ulcer formation Short Name Inhibit, gastric ulcer formation	0	Organ	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1368	Inhibition, PTGS-1 (Prostaglandin-endoperoxide synthase 1) Short Name Inhibition, PTGS-1	0	Molecular	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1369	Activation, PTGS-1 (Prostaglandin-endoperoxide synthase 1) Short Name Activation, PTGS-1	0	Molecular	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1370	Activation, PTGS-2 (Prostaglandin-endoperoxide synthase 2) Short Name Activation, PTGS-2	0	Molecular	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1371	Inhibition, PTGS-2 (Prostaglandin-endoperoxide synthase 2) Short Name	0	Molecular	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1372	Increase, bicarbonate Short Name Increase, bicarbonate	0	Molecular	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1373	Increase, mucous Short Name Increase, mucous	0	Molecular	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1374	Increase, mucosal blood flow Short Name Increase, mucosal blood flow	0	Tissue	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1375	Increase, platelet aggregation Short Name Increase, platelet aggregation	0	Tissue	Apr 17, 2017	Apr 17, 2017	217: Gastric ulcer formation
1376	Increase, angiogenesis Short Name Increase, angiogenesis	1	Tissue	Apr 17, 2017	Feb 29, 2024	2 AOPs 217: Gastric ulcer formation 439: Activation of the AhR leading to metastatic breast cancer