AOP-Wiki

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All Key Events

Showing 1001 to 1025 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1453	decreased methylation of dopamine transporter promoter Short Name	0	Cellular	Jul 24, 2017	Jul 24, 2017	72: Epigenetic modification of PPARG leading to adipogenesis
1454	chronic high fat diet Short Name chronic high fat diet	0	Individual	Jul 24, 2017	Jul 24, 2017	72: Epigenetic modification of PPARG leading to adipogenesis
1455	Incudtion, Sustained inflammatory cytokine release Short Name Sustained inflammatory cytokine release	0	Molecular	Jul 26, 2017	Jul 26, 2017	None
1456	Increase, Differentiation of fibroblasts Short Name Differentiation of fibroblasts	0	Cellular	Jul 26, 2017	Jul 26, 2017	241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
1457	Epithelial Mesenchymal Transition Short Name EMT	1	Cellular	Jul 26, 2017	Apr 24, 2024	10 AOPs 241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis 280: α-diketone-induced bronchiolitis obliterans 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis 414: Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway 415: Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway 443: DNA damage and mutations leading to Metastatic Breast Cancer 298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer 452: Adverse outcome pathway of PM-induced respiratory toxicity 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT
1458	Pulmonary fibrosis Short Name Pulmonary fibrosis	0	Organ	Jul 26, 2017	May 12, 2023	4 AOPs 241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis 481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
1459	Induction, Cell damage sensing Short Name Cell damage sensing	0	Molecular	Jul 26, 2017	Jul 26, 2017	None
1460	Increased Substance P (SP) by goblet cells Short Name SP release	0	Cellular	Jul 27, 2017	Jul 27, 2017	None
1461	Increase, DNA double-strand breaks Short Name Increase, DSB	0	Molecular	Aug 2, 2017	Nov 13, 2023	4 AOPs 202: Inhibitor binding to topoisomerase II leading to infant leukaemia 339: DNA methyltransferase inhibition leading to population decline (4) 338: DNA methyltransferase inhibition leading to population decline (3) 330: Excessive reactive oxygen species production leading to mortality (4)
1462	Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts Short Name Thiol protein adducts	0	Molecular	Aug 3, 2017	Aug 3, 2017	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
1463	Inhibition of lysyl oxidase Short Name Inhibition of lysyl oxidase	0	Cellular	Aug 3, 2017	Aug 3, 2017	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
1464	Reduction of collagen crosslinking Short Name Reduction of collagen crosslinking	0	Tissue	Aug 3, 2017	Aug 3, 2017	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
1465	Weak collagen matrix Short Name Weak collagen matrix	0	Tissue	Aug 3, 2017	Aug 3, 2017	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
1466	Notochord distortion or malformations Short Name Notochord malformation	0	Organ	Aug 3, 2017	Aug 3, 2017	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
1467	Growth, reduction Short Name Growth, reduction	0	Individual	Aug 3, 2017	Aug 3, 2017	2 AOPs 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
1468	Activation, Latent Transforming Growth Factor Beta 1 Short Name TGFbeta1 activation	0	Molecular	Aug 16, 2017	Aug 16, 2017	241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
1469	Activation, Transforming Growth Factor beta pathway Short Name TGFbeta pathway activation	0	Molecular	Aug 16, 2017	Aug 16, 2017	241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
1470	inherited mutations in offspring Short Name increase in inherited mutations	0	Individual	Aug 20, 2017	Aug 20, 2017	None
1471	Increase, Uncoupling of photophosphorylation Short Name	0	Cellular	Oct 10, 2017	Oct 10, 2017	245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
1472	Decrease, ATP production Short Name Decrease, ATP production	1	Cellular	Oct 10, 2017	Feb 4, 2026	5 AOPs 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
1473	Decrease, Chlorophyll synthesis Short Name Decrease, Chlorophyll synthesis	0	Cellular	Oct 10, 2017	Oct 10, 2017	245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
1474	Decrease, Light harvest capacity Short Name Decrease, Light harvest capacity	0	Cellular	Oct 10, 2017	Oct 10, 2017	245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
1475	Decrease, Photosynthesis Short Name Decrease, Photosynthesis	0	Cellular	Oct 10, 2017	Jan 20, 2026	4 AOPs 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants 386: Deposition of ionizing energy leading to population decline via inhibition of photosynthesis 389: Oxygen-evolving complex damage leading to population decline via inhibition of photosynthesis 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
1476	Decrease, Glycolysis Short Name Decrease, Glycolysis	0	Cellular	Oct 10, 2017	Oct 10, 2017	245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants
1477	Oxidative phosphorylation, decreased Short Name OXPHOS, decreased	0	Cellular	Oct 10, 2017	Oct 16, 2025	4 AOPs 245: Reduction in photophosphorylation leading to growth inhibition in aquatic plants 276: Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome 328: Excessive reactive oxygen species production leading to mortality (2) 387: Deposition of ionising energy leading to population decline via mitochondrial dysfunction