AOP-Wiki

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All Key Events

Showing 1251 to 1275 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1715	Inhibition of JAK3 Short Name Inhibition of JAK3	1	Molecular	Jan 5, 2020	Feb 15, 2021	315: Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
1716	Blockade of STAT5 phosphorylation Short Name STAT5 inhibition	1	Cellular	Jan 5, 2020	Mar 17, 2025	315: Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
1717	Suppression of STAT5 binding to cytokine gene promoters Short Name	1	Cellular	Jan 5, 2020	Mar 17, 2025	315: Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
1718	Suppression of IL-4 production Short Name Suppression of IL-4 production	1	Cellular	Jan 5, 2020	Mar 17, 2025	315: Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
1719	Impairment of T-cell dependent antibody response Short Name Impairment, TDAR	1	Individual	Jan 5, 2020	Feb 24, 2021	315: Inhibition of JAK3 leading to impairment of T-Cell Dependent Antibody Response
1720	Trypsin inhibition Short Name Inhibition, trypsin	0	Molecular	Jan 8, 2020	Jan 8, 2020	316: Trypsin inhibition leading to pancreatic acinar cell tumors
1721	Increased intestinal monitor peptide level Short Name Increased monitor peptide	0	Organ	Jan 8, 2020	Jan 8, 2020	316: Trypsin inhibition leading to pancreatic acinar cell tumors
1722	Increased blood CCK level Short Name Increased blood CCK level	0	Organ	Jan 8, 2020	Jan 8, 2020	316: Trypsin inhibition leading to pancreatic acinar cell tumors
1723	Increased exocrine secretion from pancreatic acinar cells Short Name	0	Cellular	Jan 8, 2020	Jan 8, 2020	316: Trypsin inhibition leading to pancreatic acinar cell tumors
1724	Acinar cell proliferation Short Name Acinar cell proliferation	0	Cellular	Jan 8, 2020	Jan 8, 2020	316: Trypsin inhibition leading to pancreatic acinar cell tumors
1725	Pancreatic acinar cell tumors Short Name Acinar cell tumors	0	Molecular	Jan 8, 2020	Jan 8, 2020	316: Trypsin inhibition leading to pancreatic acinar cell tumors
1738	SARS-CoV-2 cell entry Short Name SARS-CoV-2 cell entry	4	Cellular	Mar 1, 2020	Apr 4, 2023	10 AOPs 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) 395: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) 406: SARS-CoV-2 infection leading to hyperinflammation 407: SARS-CoV-2 infection leading to pyroptosis 426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. 422: Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
1739	Binding to ACE2 Short Name Binding to ACE2	1	Molecular	Mar 2, 2020	Oct 21, 2024	15 AOPs 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis 381: Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia 385: Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation 394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) 395: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on pericytes leads to disseminated intravascular coagulation resulting in cerebrovascular disease (stroke) 406: SARS-CoV-2 infection leading to hyperinflammation 407: SARS-CoV-2 infection leading to pyroptosis 426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. 427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure. 422: Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption 428: Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
1740	Induced dysregulation of ACE2 Short Name ACE2 enzymatic inhibition	0	Molecular	Mar 10, 2020	Mar 3, 2022	2 AOPs 319: Binding to ACE2 leading to lung fibrosis 383: Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis
1741	Induced, Angiotensin (Ang) II accumulation Short Name	0	Tissue	Mar 10, 2020	Mar 30, 2021	427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure.
1743	Increase plasma Ang II Short Name Increase plasma Ang II	0	Tissue	Mar 10, 2020	Mar 10, 2020	383: Inhibition of Angiotensin-converting enzyme 2 leading to liver fibrosis
1745	Increase,collagen synthesis Short Name Increase,collagen synthesis	0	Cellular	Mar 10, 2020	Mar 10, 2020	None
1746	Induction lung fibrosis Short Name Induction lung fibrosis	0	Organ	Mar 10, 2020	Mar 10, 2020	None
1748	Increase, the risk of acute respiratory failure Short Name	0	Organ	Mar 10, 2020	Mar 10, 2020	2 AOPs 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS)
1750	Increased inflammatory immune responses Short Name Increased inflammatory immune responses	0	Tissue	Mar 10, 2020	Jan 21, 2021	2 AOPs 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction.
1751	Decreased mortality Short Name Decreased mortality	0	Individual	Mar 17, 2020	Mar 17, 2020	None
1752	Increased Angiotensin II Short Name Increased AngII	0	Cellular	Mar 17, 2020	Apr 4, 2021	4 AOPs 319: Binding to ACE2 leading to lung fibrosis 384: Hyperactivation of ACE/Ang-II/AT1R axis leading to chronic kidney disease 385: Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation 381: Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
1753	Chronic reactive oxygen species Short Name Chronic ROS	1	Molecular	Mar 23, 2020	Jun 12, 2025	None
1754	Increase, porcupine-induced Wnt secretion and Wnt signaling activation Short Name	1	Cellular	Mar 23, 2020	Jun 4, 2025	298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer
1755	beta-catenin activation Short Name beta-catenin activation	1	Cellular	Mar 23, 2020	Nov 25, 2022	298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer