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All Key Events

Showing 851 to 875 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1548	Necrotic Tissue Short Name Necrotic Tissue	0	Tissue	Dec 19, 2018	Mar 7, 2019	2 AOPs 273: Mitochondrial complex inhibition leading to liver injury 278: IKK complex inhibition leading to liver injury
1547	Mitochondrial Injury Short Name Mitochondrial Injury	0	Cellular	Dec 19, 2018	Dec 19, 2018	2 AOPs 273: Mitochondrial complex inhibition leading to liver injury 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
1545	Decreased, mitochondrial oxidative phosphorylation Short Name	0	Cellular	Dec 19, 2018	Feb 4, 2026	2 AOPs 273: Mitochondrial complex inhibition leading to liver injury 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
1544	Mitochondrial Complex V inhibition Short Name Mitochondrial Complex V inhibition	0	Molecular	Dec 19, 2018	Mar 7, 2019	273: Mitochondrial complex inhibition leading to liver injury
1543	Mitochondrial Complex IV inhibition Short Name Mitochondrial Complex IV inhibition	0	Molecular	Dec 19, 2018	Mar 7, 2019	2 AOPs 273: Mitochondrial complex inhibition leading to liver injury 589: Inhibition of the mitochondrial complex IV of nigro-striatal neurons leads to parkinsonian motor deficits
1542	Inhibition, Mitochondrial complex III Short Name Inhibition, Mitochondrial complex III	1	Molecular	Dec 19, 2018	Oct 3, 2025	4 AOPs 273: Mitochondrial complex inhibition leading to liver injury 286: Mitochondrial complex III antagonism leading to growth inhibition (1) 287: Mitochondrial complex III antagonism leading to growth inhibition (2) 587: Inhibition of the mitochondrial complex III of nigro-striatal neurons leads to parkinsonian motor deficits
1541	Mitochondrial Complex I inhibition Short Name Mitochondrial Complex I inhibition	0	Molecular	Dec 19, 2018	Dec 19, 2018	564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
1540	lysosomal disruption EMPTY Short Name lysosomal EMPTY	0	Molecular	Nov 12, 2018	Apr 17, 2024	None
1539	Endocytotic lysosomal uptake Short Name Endocytosis	1	Molecular	Nov 6, 2018	Aug 29, 2024	2 AOPs 144: Endocytic lysosomal uptake leading to liver fibrosis 530: Endocytotic lysosomal uptake leads to intestinal barrier disruption
1538	Decreased protection against oxidative stress Short Name	0	Cellular	Sep 13, 2018	Jul 15, 2022	2 AOPs 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory 284: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress leads to chronic kidney disease
1537	Disruption, Sarcomere assembly Short Name Disruption, Sarcomere assembly	0	Cellular	Jun 21, 2018	Jun 21, 2018	261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
1536	Disruption, Intracellular calcium mobilization Short Name	0	Cellular	Jun 21, 2018	Jun 21, 2018	261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
1535	Heart failure Short Name Heart failure	1	Organ	Jun 19, 2018	Dec 3, 2024	11 AOPs 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 426: SARS-CoV-2 spike protein binding to ACE2 receptors expressed on pericytes leads to endothelial cell dysfunction, microvascular injury and myocardial infarction. 427: ACE2 downregulation following SARS-CoV-2 infection triggers dysregulation of RAAS and can lead to heart failure. 539: Decreased Sodium/Potassium ATPase activity leads to Heart failure 550: Increased LMNA gene mutation leading to heart failure 553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure 555: Inhibition, Ether-a-go-go (ERG) Voltage-Gated Potassium Channel leading to heart failure 556: Decreased Na/K ATPase activity leading to heart failure 558: Phosphodiesterase inhibition leading to heart failure 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
1534	Decrease, Blood pressure Short Name Decrease, Blood pressure	0	Individual	Jun 19, 2018	Jun 19, 2018	None
1533	Decrease, Cardiac ejection fraction Short Name Decrease, Cardiac ejection fraction	0	Organ	Jun 19, 2018	Jun 19, 2018	261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
1532	Decrease, Cardiac contractility Short Name Decrease, Cardiac contractility	0	Organ	Jun 19, 2018	Jun 19, 2018	6 AOPs 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility 479: Mitochondrial complexes inhibition leading to left ventricular function decrease via increased myocardial oxidative stress 480: Mitochondrial complexes inhibition leading to heart failure via decreased ATP production 553: Inhibition of Voltage-gated sodium channels (Na⁺ channels) leading to heart failure 556: Decreased Na/K ATPase activity leading to heart failure 558: Phosphodiesterase inhibition leading to heart failure
1531	Decrease, Calcium binding to Troponin C Short Name Decrease, Calcium binding to Troponin C	0	Cellular	Jun 19, 2018	Jun 19, 2018	261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
1530	Decrease, Calcium currents Short Name Decrease, Calcium currents	0	Cellular	Jun 19, 2018	Jun 19, 2018	261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility
1529	Blockade, L-Type Calcium Channels Short Name Blockade, L-Type Calcium Channels	0	Molecular	Jun 19, 2018	Nov 1, 2018	2 AOPs 261: L-type calcium channel blockade leading to heart failure via decrease in cardiac contractility 552: Inhibiton of L-Type Calcium Channels leading to heart failure via QT interval prolongation and Torsades de Pointes (TdP)
1528	Fatty Acid Beta Oxidation, Decreased Short Name Fatty Acid Beta Oxidation, Decreased	1	Molecular	Jun 11, 2018	Apr 30, 2019	6: Antagonist binding to PPARα leading to body-weight loss
1527	Increase, Cell membrane depolarization Short Name Increase, Cell membrane depolarization	0	Cellular	May 24, 2018	May 24, 2018	3 AOPs 361: Sulfonylureareceptor binding leading to mortality 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity
1526	Increase, Opening of voltage-dependent calcium channel Short Name	0	Cellular	May 24, 2018	May 24, 2018	361: Sulfonylureareceptor binding leading to mortality
1525	Increase, Sulfonylurea receptor binding Short Name Increase, SUR binding	0	Molecular	May 24, 2018	May 24, 2018	361: Sulfonylureareceptor binding leading to mortality
1524	Increase, Premature molting Short Name Increase, Premature molting	1	Individual	May 24, 2018	Feb 17, 2021	5 AOPs 358: Chitinase inhibition leading to mortality 359: Chitobiase inhibition leading to mortality 360: Chitin synthase 1 inhibition leading to mortality 361: Sulfonylureareceptor binding leading to mortality 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1
1523	Decrease, Cuticular chitin content Short Name Decrease, Cuticular chitin content	1	Tissue	May 24, 2018	Feb 17, 2021	3 AOPs 360: Chitin synthase 1 inhibition leading to mortality 361: Sulfonylureareceptor binding leading to mortality 606: Ecdysone receptor antagonism leading to mortality via inhibition of chitin synthase 1