AOP-Wiki

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All Key Events

Showing 926 to 950 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1468	Activation, Latent Transforming Growth Factor Beta 1 Short Name TGFbeta1 activation	0	Molecular	Aug 16, 2017	Aug 16, 2017	241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
1467	Growth, reduction Short Name Growth, reduction	0	Individual	Aug 3, 2017	Aug 3, 2017	2 AOPs 242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity 549: Aromatase inhibition leads to reproductive toxicity (including growth and developmental toxicity) in adult female zebrafish
1466	Notochord distortion or malformations Short Name Notochord malformation	0	Organ	Aug 3, 2017	Aug 3, 2017	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
1465	Weak collagen matrix Short Name Weak collagen matrix	0	Tissue	Aug 3, 2017	Aug 3, 2017	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
1464	Reduction of collagen crosslinking Short Name Reduction of collagen crosslinking	0	Tissue	Aug 3, 2017	Aug 3, 2017	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
1463	Inhibition of lysyl oxidase Short Name Inhibition of lysyl oxidase	0	Cellular	Aug 3, 2017	Aug 3, 2017	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
1462	Thiol group of chemicals interact with sulfuhydryl groups of proteins to form thiol adducts Short Name Thiol protein adducts	0	Molecular	Aug 3, 2017	Aug 3, 2017	242: Inhibition of lysyl oxidase leading to enhanced chronic fish toxicity
1461	Increase, DNA double-strand breaks Short Name Increase, DSB	0	Molecular	Aug 2, 2017	Nov 13, 2023	4 AOPs 202: Inhibitor binding to topoisomerase II leading to infant leukaemia 339: DNA methyltransferase inhibition leading to population decline (4) 338: DNA methyltransferase inhibition leading to population decline (3) 330: Excessive reactive oxygen species production leading to mortality (4)
1460	Increased Substance P (SP) by goblet cells Short Name SP release	0	Cellular	Jul 27, 2017	Jul 27, 2017	None
1459	Induction, Cell damage sensing Short Name Cell damage sensing	0	Molecular	Jul 26, 2017	Jul 26, 2017	None
1458	Pulmonary fibrosis Short Name Pulmonary fibrosis	0	Organ	Jul 26, 2017	May 12, 2023	4 AOPs 241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis 173: Substance interaction with the pulmonary resident cell membrane components leading to pulmonary fibrosis 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis 481: AOPs of amorphous silica nanoparticles: ROS-mediated oxidative stress increased respiratory dysfunction and diseases.
1457	Epithelial Mesenchymal Transition Short Name EMT	1	Cellular	Jul 26, 2017	Apr 24, 2024	10 AOPs 241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis 206: Peroxisome proliferator-activated receptors γ inactivation leading to lung fibrosis 280: α-diketone-induced bronchiolitis obliterans 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis 414: Aryl hydrocarbon receptor activation leading to lung fibrosis through TGF-β dependent fibrosis toxicity pathway 415: Aryl hydrocarbon receptor activation leading to lung fibrosis through IL-6 toxicity pathway 443: DNA damage and mutations leading to Metastatic Breast Cancer 298: Increase in reactive oxygen species (ROS) leading to human treatment-resistant gastric cancer 452: Adverse outcome pathway of PM-induced respiratory toxicity 474: Succinate dehydrogenase inactivation leads to cancer by promoting EMT
1456	Increase, Differentiation of fibroblasts Short Name Differentiation of fibroblasts	0	Cellular	Jul 26, 2017	Jul 26, 2017	241: Latent Transforming Growth Factor beta1 activation leads to pulmonary fibrosis
1455	Incudtion, Sustained inflammatory cytokine release Short Name Sustained inflammatory cytokine release	0	Molecular	Jul 26, 2017	Jul 26, 2017	None
1454	chronic high fat diet Short Name chronic high fat diet	0	Individual	Jul 24, 2017	Jul 24, 2017	72: Epigenetic modification of PPARG leading to adipogenesis
1453	decreased methylation of dopamine transporter promoter Short Name	0	Cellular	Jul 24, 2017	Jul 24, 2017	72: Epigenetic modification of PPARG leading to adipogenesis
1452	decreased DNA methylation of tyrosine hydroxylase Short Name	0	Cellular	Jul 24, 2017	Jul 24, 2017	72: Epigenetic modification of PPARG leading to adipogenesis
1451	decreased reward Short Name decreased reward	0	Individual	Jul 24, 2017	Jul 24, 2017	72: Epigenetic modification of PPARG leading to adipogenesis
1450	decreased dopamine Short Name decreased dopamine	0	Molecular	Jul 24, 2017	Jul 24, 2017	72: Epigenetic modification of PPARG leading to adipogenesis
1449	increased adipogenesis Short Name increased adipogenesis	0	Tissue	Jul 24, 2017	Jul 24, 2017	72: Epigenetic modification of PPARG leading to adipogenesis
1448	activation of CCAAT/enhancer-binding protein alpha Short Name activation of CEBPA	0	Molecular	Jul 24, 2017	Jul 24, 2017	72: Epigenetic modification of PPARG leading to adipogenesis
1447	obesity Short Name obesity	0	Individual	Jul 24, 2017	Jul 24, 2017	72: Epigenetic modification of PPARG leading to adipogenesis
1446	Decrease, Coupling of oxidative phosphorylation Short Name Decrease, Coupling of OXPHOS	3	Cellular	Jun 29, 2017	Nov 7, 2025	15 AOPs 267: Uncoupling of oxidative phosphorylation leading to growth inhibition via glucose depletion 263: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased cell proliferation 264: Uncoupling of oxidative phosphorylation leading to growth inhibition via ATP depletion associated cell death 265: Uncoupling of oxidative phosphorylation leading to growth inhibition via increased cytosolic calcium 266: Uncoupling of oxidative phosphorylation leading to growth inhibition via decreased Na-K ATPase activity 268: Uncoupling of oxidative phosphorylation leading to growth inhibition via mitochondrial swelling 534: Succinate dehydrogenase (SDH) inhibition leads to oxidative stress 331: Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 596: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and cell injury/death 598: Excessive reactive oxygen species leading to growth inhibition via protein oxidation and reduced cell proliferation 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production 326: Reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation 332: Reactive oxygen species leading to growth inhibition via protein oxidation and decreased cell proliferation 333: Reactive oxygen species leading to growth inhibition via protein oxidation and cell death
1445	Increase, Lipid peroxidation Short Name Increase, LPO	1	Molecular	Jun 29, 2017	Jun 23, 2026	7 AOPs 329: Excessive reactive oxygen species production leading to mortality (3) 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure 492: Glutathione conjugation leading to reproductive dysfunction via oxidative stress 521: Essential element imbalance leads to reproductive failure via oxidative stress 331: Reactive oxygen species leading to growth inhibition via lipid peroxidation and cell death 615: Suppression of Keap1 cysteine oxidation leading to liver inflammation 326: Reactive oxygen species leading to growth inhibition via lipid peroxidation and decreased cell proliferation
1444	Increase, Follicular atresia Short Name Increase, Follicular atresia	0	Organ	Jun 29, 2017	Nov 25, 2020	2 AOPs 216: Deposition of energy leading to population decline via DNA strand breaks and follicular atresia 299: Deposition of energy leading to population decline via DNA oxidation and follicular atresia