AOP-Wiki

API

All Key Events

Showing 1076 to 1100 of 1939 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

1314	Activation, LRH-1 Short Name Activation, LRH-1	0	Molecular	Apr 13, 2017	Apr 13, 2017	None
1313	Decrease, cytosolic fatty acid Short Name Decrease, cytosolic fatty acid	0	Molecular	Apr 13, 2017	Apr 13, 2017	None
1312	Increase, Fatty acid beta-oxidation Short Name Increase, Fatty acid β-oxidation	0	Cellular	Apr 13, 2017	Dec 4, 2020	2 AOPs 612: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via reduced adenosine triphosphate 613: Peroxisome proliferator-activated receptor alpha activation leading to early life stage mortality via increased reactive oxygen species production
1310	Activation, PI3K Short Name Activation, PI3K	0	Molecular	Apr 13, 2017	Apr 13, 2017	401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
1309	Activation, aPKC Short Name Activation, aPKC	0	Molecular	Apr 13, 2017	Apr 13, 2017	None
1308	Inhibition, LRH-1 Short Name Inhibition, LRH-1	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1307	Inhibition, LXR Short Name Inhibition, LXR	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1306	Increase, De novo lipogenesis Short Name Increase, De novo lipogenesis	0	Cellular	Apr 12, 2017	Feb 10, 2026	3 AOPs 627: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated mitochondrial dysfunction 628: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated oxidative stress 629: Increased 11β-Hydroxysteroid dehydrogenase type 1 activity leading to MASLD progression via lipogenesis-associated endoplasmic reticulum stress
1305	Increase, cytosolic fatty acid Short Name Increase, cytosolic fatty acid	0	Cellular	Apr 12, 2017	Nov 27, 2017	213: Inhibition of fatty acid beta oxidation leading to nonalcoholic steatohepatitis (NASH)
1304	Activation, FXR Short Name Activation, FXR	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1303	Activation, HSD17B4 Short Name Activation, HSD17B4	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1302	Activation, L-FABP Short Name Activation, L-FABP	0	Molecular	Apr 12, 2017	Apr 13, 2017	None
1301	Activation, SREBP-1 Short Name Activation, SREBP-1	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1300	Activation, mTORC1 Short Name Activation, mTORC1	0	Molecular	Apr 12, 2017	Apr 12, 2017	401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
1299	Activation, AKT Short Name Activation, AKT	0	Molecular	Apr 12, 2017	Apr 12, 2017	401: G protein-coupled estrogen receptor 1 (GPER) signal pathway in the lipid metabolism disrupting effects
1298	Activation, mTORC2 Short Name Activation, mTORC2	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1297	Activation, insulin receptor Short Name Activation, insulin receptor	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1296	Increase, insulin Short Name Increase, insulin	0	Molecular	Apr 12, 2017	Apr 12, 2017	None
1295	Defect of Embryogenesis Short Name Defect of Embryogenesis	1	Tissue	Feb 15, 2017	Sep 16, 2017	210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
1294	Inhibition, Wnt pathway Short Name Inhibition, Wnt pathway	1	Cellular	Feb 15, 2017	Sep 16, 2017	210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building
1293	Activation, FOXO Short Name Activation, FOXO	1	Cellular	Feb 15, 2017	Sep 16, 2017	2 AOPs 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building 591: DBDPE-induced DNA damage increase in liver leading to Non-alcoholic fatty liver disease via liver steatosis and inhibition of regeneration
1292	Activation, JNK Short Name Activation, JNK	1	Cellular	Feb 15, 2017	Sep 16, 2017	2 AOPs 210: Activation of c-Jun N-terminal kinase (JNK) and Forkhead box O (FOXO) and reduction of WNT pathways leading to reproductive failure: Integrated multi-OMICS approach for AOP building 347: Toll-like receptor 4 activation and peroxisome proliferator-activated receptor gamma inactivation leading to pulmonary fibrosis
1291	Hepatotoxicity Short Name Hepatotoxicity	0	Cellular	Feb 15, 2017	Feb 15, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1290	Glutathione homeostasis Short Name Glutathione homeostasis	1	Cellular	Feb 15, 2017	Sep 16, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1289	Perturbation of cholesterol Short Name Perturbation of cholesterol	1	Cellular	Feb 15, 2017	Sep 16, 2017	209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP