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All Key Events

Showing 376 to 400 of 1907 Key Events

ID	Title	Event Component Count	Biological Organization	Created At	Last Updated	AOPs

724	Inhibition, Pyruvate dehydrogenase kinase (PDK) enzyme Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
726	Increased, Induction of pyruvate dehydrogenase (PDH) Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	108: Inhibition of pyruvate dehydrogenase kinase leading to hepatocellular adenomas and carcinomas (in mouse and rat)
728	Increase, Aneuploid offspring Short Name Increase, Aneuploid offspring	1	Individual	Nov 29, 2016	May 27, 2019	106: Chemical binding to tubulin in oocytes leading to aneuploid offspring
733	Increase, Necrosis (terminal bronchiolar cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
734	Increase, Regenerative cell proliferation (terminal bronchiolar epithelial cells) Short Name	1	Cellular	Nov 29, 2016	Dec 3, 2016	109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
735	Increase, Hyperplasia (terminal bronchiolar cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
736	Increase, Adenomas/carcinomas (bronchioloalveolar) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	109: Cytotoxicity leading to bronchioloalveolar adenomas and carcinomas (in mouse)
737	Decreased, Uptake of inorganic iodide Short Name Decreased, Uptake of inorganic iodide	1	Cellular	Nov 29, 2016	Sep 16, 2017	None
739	Increase, Hypertrophy and proliferation (follicular cell) Short Name	2	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
740	Increase, Hyperplasia (follicular cells) Short Name	1	Cellular	Nov 29, 2016	Sep 16, 2017	3 AOPs 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
741	Increase, Adenomas/carcinomas (follicular cell) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	3 AOPs 110: Inhibition of iodide pump activity leading to follicular cell adenomas and carcinomas (in rat and mouse) 119: Inhibition of thyroid peroxidase leading to follicular cell adenomas and carcinomas (in rat and mouse) 162: Enhanced hepatic clearance of thyroid hormones leading to thyroid follicular cell adenomas and carcinomas in the rat and mouse
743	Decreased, Testosterone binding to androgen receptor (hypothalamus) Short Name	1	Molecular	Nov 29, 2016	Sep 16, 2017	111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
744	Increase, Hyperplasia (Leydig cells) Short Name Increase, Hyperplasia (Leydig cells)	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) 120: Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
745	Increase, Leydig cell tumors Short Name Increase, Leydig cell tumors	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat) 120: Inhibition of 5α-reductase leading to Leydig cell tumors (in rat)
746	Increase, Dopaminergic activity Short Name Increase, Dopaminergic activity	1	Cellular	Nov 29, 2016	Sep 16, 2017	2 AOPs 112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat) 611: Behavioral abnormalities due to increased expression of dopamine transporter and receptor-related genes
747	Decreased, Prolactin Short Name Decreased, Prolactin	1	Tissue	Nov 29, 2016	Sep 16, 2017	112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
748	Increased, Estrogen receptor (ER) activity Short Name	1	Molecular	Nov 29, 2016	Dec 3, 2016	465: Alcohol dehydrogenase leading to reproductive dysfunction
749	Decreased, Progesterone from corpus luteum Short Name	1	Tissue	Nov 29, 2016	Sep 16, 2017	112: Increased dopaminergic activity leading to endometrial adenocarcinomas (in Wistar rat)
752	Altered, Meiotic chromosome dynamics Short Name Altered, Meiotic chromosome dynamics	1	Cellular	Nov 29, 2016	May 27, 2019	3 AOPs 106: Chemical binding to tubulin in oocytes leading to aneuploid offspring 396: Deposition of ionizing energy leads to population decline via impaired meiosis 435: Deposition of ionising energy leads to population decline via pollen abnormal
753	Increase, Thyroid-stimulating hormone (TSH) Short Name	2	Tissue	Nov 29, 2016	Sep 16, 2017	None
754	Increased, Luteinizing hormone (LH) Short Name Increased, Luteinizing hormone (LH)	1	Tissue	Nov 29, 2016	Sep 16, 2017	111: Decrease in androgen receptor activity leading to Leydig cell tumors (in rat)
756	Hippocampal gene expression, Altered Short Name Hippocampal gene expression, Altered	1	Tissue	Nov 29, 2016	Aug 11, 2018	7 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals
757	Hippocampal anatomy, Altered Short Name Hippocampal anatomy, Altered	1	Tissue	Nov 29, 2016	Jul 24, 2024	6 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 442: Binding to voltage gate sodium channels during development leads to cognitive impairment
758	Hippocampal Physiology, Altered Short Name Hippocampal Physiology, Altered	1	Tissue	Nov 29, 2016	Jul 24, 2024	9 AOPs 42: Inhibition of Thyroperoxidase and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 8: Upregulation of Thyroid Hormone Catabolism via Activation of Hepatic Nuclear Receptors, and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 134: Sodium Iodide Symporter (NIS) Inhibition and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity 300: Thyroid Receptor Antagonism and Subsequent Adverse Neurodevelopmental Outcomes in Mammals 490: Co-activation of IP3R and RyR leads to reduced IQ and increased socio-economic burden through non-cholinergic mechanisms 458: AhR activation in the liver leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 459: AhR activation in the thyroid leading to Subsequent Adverse Neurodevelopmental Outcomes in Mammals 442: Binding to voltage gate sodium channels during development leads to cognitive impairment
759	Increased, Kidney Failure Short Name Increased, Kidney Failure	1	Population	Nov 29, 2016	Jan 16, 2019	5 AOPs 33: Kidney toxicity induced by activation of 5HT2C 377: Dysregulated prolonged Toll Like Receptor 9 (TLR9) activation leading to Multi Organ Failure involving Acute Respiratory Distress Syndrome (ARDS) 413: Oxidation and antagonism of reduced glutathione leading to mortality via acute renal failure 447: Kidney failure induced by inhibition of mitochondrial electron transfer chain through apoptosis, inflammation and oxidative stress pathways 622: Calcineurin inhibitor induced nephrotoxicity leading to kidney failure