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Showing 26 to 50 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3464	2250: HSD17B2 inhibition	2251: Increased E2 availability	Jan 2, 2025	Jan 2, 2025	1 AOP 565: 17β-Hydroxysteroid dehydrogenase 2, inhibition leading to activation, estrogen receptor alpha
1495	1387: 7α-hydroxypregnenolone synthesis in the brain, decreased	1389: Locomotor activity, decreased	May 2, 2017	May 17, 2017	1 AOP 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
1496	1387: 7α-hydroxypregnenolone synthesis in the brain, decreased	1388: Dopamine release in the brain, decreased	May 2, 2017	May 25, 2017	2 AOPs 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
1498	1387: 7α-hydroxypregnenolone synthesis in the brain, decreased	1390: Sexual behavior, decreased	May 3, 2017	May 17, 2017	1 AOP 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
356	382: Aberrant, Dendritic morphology	385: Synaptogenesis, Decreased	Nov 29, 2016	Nov 29, 2016	1 AOP 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities
3122	2208: Aberrant, synaptic formation and plasticity	386: Neuronal network function, Decreased	Jan 25, 2024	Jan 25, 2024	1 AOP 522: Estrogen antagonism leading to increased risk of autism-like behavior
3253	2208: Aberrant, synaptic formation and plasticity	341: Impairment, Learning and memory	Jun 19, 2024	Jun 19, 2024	1 AOP 535: Binding and activation of GPER leading to learning and memory impairments
2997	2166: Abnormal expression of NO	1928: increased，Vascular endothelial dysfunction	Aug 20, 2023	Aug 20, 2023	1 AOP 510: Demethylation of PPAR promotor leading to vascular disrupting effects
3459	2301: Abnormal, Behavior	566: impaired, Larval development	Dec 24, 2024	Dec 24, 2024	1 AOP 564: DBDPE-induced inhibition of mitochondrial complex Ⅰ leading to population decline via neurotoxicity and metabotoxicity.
569	560: Abnormal, Foraging activity and behavior	572: Decrease, Number of worker bees	Nov 29, 2016	Dec 3, 2016	2 AOPs 81: Increased metabolic stress contributes to abnormal foraging and leads to colony loss/failure 85: Suppression of immune system contributes to abnormal foraging and leads to colony loss/failure
584	560: Abnormal, Foraging activity and behavior	561: Reduced, Food storage	Nov 29, 2016	Dec 3, 2016	None
1144	560: Abnormal, Foraging activity and behavior	1107: Weakened, Colony	Nov 29, 2016	Dec 3, 2016	5 AOPs 77: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony death/failure 1 88: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure via abnormal role change within caste 180: Varroa mite infestation contributes to abnormal foraging leading to colony loss/failure 182: Weather event contributes abnormal foraging leading to colony loss/failure 183: Nosema infection increases energetic demands leading to colony loss/failure
1148	560: Abnormal, Foraging activity and behavior	564: Abnormal, Roll change within caste	Nov 29, 2016	Dec 3, 2016	None
1150	560: Abnormal, Foraging activity and behavior	1108: Abnormal, Role change within caste	Nov 29, 2016	Dec 3, 2016	2 AOPs 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure
2531	1952: Abnormal, Glucose homeostasis	1953: GDM	Nov 18, 2021	Nov 18, 2021	1 AOP 431: Increased tumor necrosis factor (TNF) leading to increased risk of gestational diabetes mellitus (GDM)
196	183: Abnormal, Morphogenesis	342: Increased, Lethality	Nov 29, 2016	Dec 3, 2016	None
197	183: Abnormal, Morphogenesis	366: Increased, Structural malformations	Nov 29, 2016	Dec 3, 2016	None
1025	183: Abnormal, Morphogenesis	1001: Increased, Developmental Defects	Nov 29, 2016	Dec 3, 2016	None
2408	1891: abnormal, placental labyrinth vasculature morphology	1892: increase, placental insufficiency	May 31, 2021	May 31, 2021	1 AOP 151: AhR activation leading to preeclampsia
1151	1108: Abnormal, Role change within caste	1107: Weakened, Colony	Nov 29, 2016	Dec 3, 2016	3 AOPs 89: Nicotinic acetylcholine receptor activation followed by desensitization contributes to abnormal foraging and directly leads to colony loss/failure 87: Nicotinic acetylcholine receptor activation contributes to abnormal foraging and leads to colony loss/failure 184: Nosema infection causes abnormal role change that leads to colony loss/failure
565	564: Abnormal, Roll change within caste	565: Reduced, Brood care	Nov 29, 2016	Dec 3, 2016	3 AOPs 82: Abnormal role change in worker caste contributes to reduced brood care and leads to colony loss/failure 90: Nicotinic acetylcholine receptor activation contributes to abnormal roll change within the worker bee caste leading to colony loss/failure 2 78: Nicotinic acetylcholine receptor activation contributes to abnormal role change within the worker bee caste leading to colony death failure 1
579	564: Abnormal, Roll change within caste	561: Reduced, Food storage	Nov 29, 2016	Dec 3, 2016	1 AOP 86: Decrease Glucose oxidase activity contributes to reduction of antiseptic in food and leads to colony loss/failure
580	564: Abnormal, Roll change within caste	572: Decrease, Number of worker bees	Nov 29, 2016	Dec 3, 2016	None
1149	564: Abnormal, Roll change within caste	1107: Weakened, Colony	Nov 29, 2016	Dec 3, 2016	None
3299	2242: Dendritic spine abnormality	341: Impairment, Learning and memory	Jul 14, 2024	Jul 14, 2024	None

Key Event Relationships (KERs)

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