AOP-Wiki

API

All KERs

Showing 526 to 550 of 3164 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

3195	2219: Binding of (ant)agonist to PPAR alpha	2223: Reduced number of oligodendrocytes	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
2319	1851: Binding of agonist, Angiotensin II receptor type 1 receptor (AT1R)	1115: Increase, ROS	Apr 10, 2021	Apr 10, 2021	2 AOPs 382: Angiotensin II type 1 receptor (AT1R) agonism leading to lung fibrosis 319: Binding to ACE2 leading to lung fibrosis
919	875: Binding of agonist, Ionotropic glutamate receptors	388: Overactivation, NMDARs	Nov 29, 2016	Nov 29, 2016	2 AOPs 48: Binding of agonists to ionotropic glutamate receptors in adult brain causes excitotoxicity that mediates neuronal cell death, contributing to learning and memory impairment. 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
3506	875: Binding of agonist, Ionotropic glutamate receptors	2078: Loss of drebrin	Mar 9, 2025	Mar 9, 2025	1 AOP 475: Binding of chemicals to ionotropic glutamate receptors leads to impairment of learning and memory via loss of drebrin from dendritic spines of neurons
360	387: Binding of agonist, NMDARs	388: Overactivation, NMDARs	Nov 29, 2016	Nov 29, 2016	None
3182	2217: Binding of antagonist to glucocorticoid hormone receptor	2220: GR antagonism	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
3181	2216: Binding of antagonist to thyroid hormone receptor	1656: TR Antagnoism	Apr 12, 2024	Apr 12, 2024	1 AOP 525: Reduced oligodendrocyte differentiation during neurodevelopment leading to impaired learning and memory
228	201: Binding of antagonist, NMDA receptors	341: Impairment, Learning and memory	Nov 29, 2016	Dec 3, 2016	None
229	201: Binding of antagonist, NMDA receptors	195: Inhibition, NMDARs	Nov 29, 2016	Jun 13, 2018	2 AOPs 13: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development induces impairment of learning and memory abilities 12: Chronic binding of antagonist to N-methyl-D-aspartate receptors (NMDARs) during brain development leads to neurodegeneration with impairment in learning and memory in aging
1023	998: Binding of antagonist, PPAR alpha	1000: stabilization, PPAR alpha co-repressor	Nov 29, 2016	Jun 11, 2018	1 AOP 6: Antagonist binding to PPARα leading to body-weight loss
1944	1653: Binding of inhibitor, mitochondrial complex III	1542: Inhibition, Mitochondrial complex III	Jun 7, 2019	Jun 7, 2019	1 AOP 273: Mitochondrial complex inhibition leading to liver injury
1945	1654: Binding of inhibitor, mitochondrial complex IV	1543: Mitochondrial Complex IV inhibition	Jun 7, 2019	Jun 7, 2019	1 AOP 273: Mitochondrial complex inhibition leading to liver injury
1946	1655: Binding of inhibitor, mitochondrial complex V	1544: Mitochondrial Complex V inhibition	Jun 7, 2019	Jun 7, 2019	1 AOP 273: Mitochondrial complex inhibition leading to liver injury
933	888: Binding of inhibitor, NADH-ubiquinone oxidoreductase (complex I)	887: Inhibition, NADH-ubiquinone oxidoreductase (complex I)	Nov 29, 2016	Aug 25, 2017	3 AOPs 3: Inhibition of the mitochondrial complex I of nigro-striatal neurons leads to parkinsonian motor deficits 276: Inhibition of complex I of the electron transport chain leading to chemical induced Fanconi syndrome 273: Mitochondrial complex inhibition leading to liver injury
1833	1580: Binding of MSAs to microtubules	1581: Disturbance in microtubule dynamic instability	Jan 29, 2019	Jan 29, 2019	1 AOP 279: Microtubule interacting drugs lead to peripheral neuropathy
3556	2307: Binding to the QB site D1 protein	1862: Decrease, Photosystem II efficiency	Aug 5, 2025	Feb 23, 2026	1 AOP 567: Binding to plastoquinone B site leading to decreased population growth rate via photosystem II inhibition
1677	1486: Binding of substrate, endocytic receptor	831: Disturbance, Lysosomal function	Oct 25, 2017	Oct 25, 2017	1 AOP 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
1330	1252: Binding, topoisomerase II	1253: MLL translocation	Jan 20, 2017	Apr 26, 2017	None
1634	1252: Binding, topoisomerase II	1461: Increase, DSB	Aug 2, 2017	Aug 1, 2022	1 AOP 202: Inhibitor binding to topoisomerase II leading to infant leukaemia
2056	1739: Binding to ACE2	1738: SARS-CoV-2 cell entry	Mar 2, 2020	Oct 21, 2024	7 AOPs 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) 406: SARS-CoV-2 infection leading to hyperinflammation 422: Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
2286	1739: Binding to ACE2	188: Neuroinflammation	Feb 23, 2021	Feb 23, 2021	1 AOP 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis
2294	1739: Binding to ACE2	1741: Induced, Angiotensin (Ang) II accumulation	Mar 28, 2021	Mar 28, 2021	None
2297	1739: Binding to ACE2	1752: Increased AngII	Mar 28, 2021	Mar 28, 2021	None
2299	1739: Binding to ACE2	1740: ACE2 enzymatic inhibition	Mar 28, 2021	Mar 28, 2021	None
2311	1739: Binding to ACE2	1854: ACE2 dysregulation	Mar 31, 2021	Feb 7, 2023	2 AOPs 385: Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation 428: Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis

Key Event Relationships (KERs)

All KERs