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All KERs

Showing 526 to 550 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1677	1486: Binding of substrate, endocytic receptor	831: Disturbance, Lysosomal function	Oct 25, 2017	Oct 25, 2017	1 AOP 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
1330	1252: Binding, topoisomerase II	1253: MLL translocation	Jan 20, 2017	Apr 26, 2017	None
1634	1252: Binding, topoisomerase II	1461: Increase, DSB	Aug 2, 2017	Aug 1, 2022	1 AOP 202: Inhibitor binding to topoisomerase II leading to infant leukaemia
2056	1739: Binding to ACE2	1738: SARS-CoV-2 cell entry	Mar 2, 2020	Oct 21, 2024	7 AOPs 320: Binding of SARS-CoV-2 to ACE2 receptor leading to acute respiratory distress associated mortality 394: SARS-CoV-2 infection of olfactory epithelium leading to impaired olfactory function (short-term anosmia) 406: SARS-CoV-2 infection leading to hyperinflammation 422: Binding of SARS-CoV-2 to ACE2 in enterocytes leads to intestinal barrier disruption 430: Binding of SARS-CoV-2 to ACE2 leads to viral infection proliferation 379: Binding to ACE2 leading to thrombosis and disseminated intravascular coagulation 468: Binding of SARS-CoV-2 to ACE2 leads to hyperinflammation (via cell death)
2286	1739: Binding to ACE2	188: Neuroinflammation	Feb 23, 2021	Feb 23, 2021	1 AOP 374: Binding of Sars-CoV-2 spike protein to ACE 2 receptors expressed on brain cells (neuronal and non-neuronal) leads to neuroinflammation resulting in encephalitis
2294	1739: Binding to ACE2	1741: Induced, Angiotensin (Ang) II accumulation	Mar 28, 2021	Mar 28, 2021	None
2297	1739: Binding to ACE2	1752: Increased AngII	Mar 28, 2021	Mar 28, 2021	None
2299	1739: Binding to ACE2	1740: ACE2 enzymatic inhibition	Mar 28, 2021	Mar 28, 2021	None
2311	1739: Binding to ACE2	1854: ACE2 dysregulation	Mar 31, 2021	Feb 7, 2023	2 AOPs 385: Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation 428: Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis
2312	1739: Binding to ACE2	1787: Downregulation of ACE2	Mar 31, 2021	Nov 12, 2021	2 AOPs 385: Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation 381: Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
2452	1739: Binding to ACE2	1913: Endothelial cell dysfunction	Aug 4, 2021	Aug 4, 2021	None
2522	1739: Binding to ACE2	1937: ADAM17 induction	Oct 28, 2021	Oct 28, 2021	None
2020	1710: Binding to estrogen receptor (ER)-α	1711: Induction of GATA3 expression	Dec 29, 2019	Aug 14, 2020	1 AOP 314: Binding to estrogen receptor (ER)-α in immune cells leading to exacerbation of systemic lupus erythematosus (SLE)
2534	1956: Binding to hERG channel	1958: Direct hERG channel blockage	Dec 13, 2021	Dec 13, 2021	None
2605	1353: Binding to VGSC	1977: Altered kinetics of sodium channel	Mar 21, 2022	Jul 31, 2024	1 AOP 442: Binding to voltage gate sodium channels during development leads to cognitive impairment
1253	1201: Binding, Immunophilins	980: Inhibition, Calcineurin Activity	Nov 29, 2016	Oct 25, 2017	None
287	261: Binding, SH-/selen-proteins	158: N/A, Interferences with SH-/selen-proteins	Nov 29, 2016	Dec 3, 2016	None
1683	1487: Binding, SH/SeH proteins involved in protection against oxidative stress	177: Increase, Mitochondrial dysfunction	Nov 9, 2017	Nov 9, 2017	None
1689	1487: Binding, SH/SeH proteins involved in protection against oxidative stress	1392: Increase, Oxidative Stress	Nov 9, 2017	Feb 7, 2018	None
1765	1487: Binding, SH/SeH proteins involved in protection against oxidative stress	1538: Protection against oxidative stress, decreased	Sep 13, 2018	Feb 10, 2020	1 AOP 17: Binding of electrophilic chemicals to SH(thiol)-group of proteins and /or to seleno-proteins involved in protection against oxidative stress during brain development leads to impairment of learning and memory
2250	1831: Binding, Thyroid binding globulin in serum	1830: Displacement, Serum thyroxine (T4) from carrier protein	Dec 9, 2020	Dec 9, 2020	1 AOP 367: Competitive binding to thyroid hormone carrier protein thyroid binding globulin (TBG) leading to altered amphibian metamorphosis
2245	957: Binding, Transthyretin in serum	958: Displacement, Serum thyroxine (T4) from transthyretin	Dec 9, 2020	Dec 9, 2020	1 AOP 152: Interference with thyroid serum binding protein transthyretin and subsequent adverse human neurodevelopmental toxicity
2248	957: Binding, Transthyretin in serum	1830: Displacement, Serum thyroxine (T4) from carrier protein	Dec 9, 2020	Dec 9, 2020	1 AOP 366: Competitive binding to thyroid hormone carrier protein transthyretin (TTR) leading to altered amphibian metamorphosis
2269	957: Binding, Transthyretin in serum	961: Increased, Clearance of thyroxine from serum	Jan 26, 2021	Jan 26, 2021	None
2271	957: Binding, Transthyretin in serum	959: Increased, Free serum thyroxine (T4)	Jan 26, 2021	Jan 26, 2021	None

Key Event Relationships (KERs)

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