| 1170 |
1132: Blood loss and development of anemia, Impaired oxygen delivery and nutrient delivery to tis |
1135: Reduced fitness or even mortality, Acidosis, hypovolemic shock and organ dysfunction |
Nov 29, 2016 |
Dec 3, 2016 |
1 AOP
|
| 2353 |
1867: Bradykinin, activated |
1496: Increased proinflammatory mediators |
Apr 20, 2021 |
Jan 14, 2022 |
1 AOP
|
| 2355 |
1867: Bradykinin, activated |
1866: Hypofibrinolysis |
Apr 20, 2021 |
Jan 24, 2022 |
1 AOP
|
| 2357 |
1867: Bradykinin, activated |
1868: Hyperinflammation |
Apr 20, 2021 |
Oct 19, 2021 |
1 AOP
|
| 3654 |
2093: Decreased brain T4/T3 |
1656: TR Antagnoism |
Oct 8, 2025 |
Oct 8, 2025 |
1 AOP
|
| 3658 |
2093: Decreased brain T4/T3 |
381: BDNF, Reduced |
Oct 8, 2025 |
Oct 8, 2025 |
1 AOP
|
| 2398 |
1879: Bulky DNA adducts, increase |
155: Inadequate DNA repair |
May 17, 2021 |
May 17, 2021 |
2 AOPs
|
| 2399 |
1879: Bulky DNA adducts, increase |
185: Increase, Mutations |
May 17, 2021 |
Sep 14, 2021 |
2 AOPs
|
| 3799 |
1879: Bulky DNA adducts, increase |
1636: Increase, Chromosomal aberrations |
Jun 29, 2026 |
Jul 23, 2026 |
1 AOP
|
| 3800 |
1879: Bulky DNA adducts, increase |
1635: Increase, DNA strand breaks |
Jun 29, 2026 |
Jun 29, 2026 |
1 AOP
|
| 1195 |
1149: Calcium cannot bind to the hydroxyapatite matrix of bone, Osteocalcin and other bone protei |
1150: Uncarboxylated osteocalcin not incorporated into bone matrix, decreasing bone strength, Imp |
Nov 29, 2016 |
Dec 3, 2016 |
None
|
| 3410 |
2282: Cardiac ion channels (e.g., potassium, sodium, calcium) |
1961: Prolongation of Action Potential |
Nov 21, 2024 |
Nov 21, 2024 |
1 AOP
|
| 1808 |
1560: Cell differentiation, altered |
1561: Neural tube defects |
Dec 20, 2018 |
Dec 20, 2018 |
1 AOP
|
| 2603 |
1560: Cell differentiation, altered |
1978: Microcephaly |
Mar 17, 2022 |
Mar 17, 2022 |
None
|
| 3606 |
1560: Cell differentiation, altered |
1068: Endometrial squamous metaplasia, Increase |
Aug 21, 2025 |
Aug 28, 2025 |
None
|
| 3609 |
1560: Cell differentiation, altered |
772: Increase, Hyperplasia (glandular epithelial cells of endometrium) |
Aug 26, 2025 |
Aug 29, 2025 |
None
|
| 995 |
853: Changes/Inhibition, Cellular Homeostasis and Apoptosis |
139: N/A, Hepatotoxicity, Hepatopathy, including a constellation of observable effects |
Nov 29, 2016 |
Dec 2, 2016 |
1 AOP
|
| 1613 |
1454: chronic high fat diet |
1450: decreased dopamine |
Jul 24, 2017 |
Jul 24, 2017 |
1 AOP
|
| 2069 |
1753: Chronic ROS |
1754: Increase, porcupine-induced Wnt secretion and Wnt signaling activation |
Mar 23, 2020 |
Jun 12, 2025 |
None
|
| 1314 |
1251: Chronic, Mucus hypersecretion |
1250: Decreased lung function |
Nov 29, 2016 |
Aug 30, 2021 |
None
|
| 2442 |
1908: CBF, Decreased |
1909: MCC, Decreased |
Jul 19, 2021 |
Mar 24, 2023 |
3 AOPs
|
| 550 |
491: Clonal Expansion/Cell Proliferation, to form Altered Hepatic Foci (AHF) |
378: Tumorigenesis, Hepatocellular carcinoma |
Nov 29, 2016 |
Nov 29, 2016 |
1 AOP
|
| 2290 |
1845: Coagulation |
1846: Thrombosis and DIC |
Mar 25, 2021 |
Jun 23, 2024 |
1 AOP
|
| 2313 |
1845: Coagulation |
1392: Increase, Oxidative Stress |
Apr 8, 2021 |
Apr 8, 2021 |
None
|
| 2360 |
1845: Coagulation |
1869: Diminished Protective Response to ROS |
Apr 20, 2021 |
Jun 21, 2024 |
1 AOP
|