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Showing 1101 to 1125 of 3081 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

846	831: Disturbance, Lysosomal function	837: Occurrence, Cytoplasmic vacuolization (kupffer cell)	Nov 29, 2016	Dec 3, 2016	1 AOP 130: Phospholipase A2 (LPLA2) inhibitors leading to hepatotoxicity
1678	831: Disturbance, Lysosomal function	898: Disruption, Lysosome	Oct 25, 2017	Oct 25, 2017	1 AOP 257: Receptor mediated endocytosis and lysosomal overload leading to kidney toxicity
1497	1388: Dopamine release in the brain, decreased	1389: Locomotor activity, decreased	May 2, 2017	May 2, 2017	1 AOP 218: Inhibition of CYP7B activity leads to decreased reproductive success via decreased locomotor activity
1502	1388: Dopamine release in the brain, decreased	1390: Sexual behavior, decreased	May 9, 2017	May 9, 2017	1 AOP 219: Inhibition of CYP7B activity leads to decreased reproductive success via decreased sexual behavior
520	472: Down Regulation, CPT1A	179: Decrease, Fatty acid β-oxidation	Nov 29, 2016	Dec 3, 2016	1 AOP 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
1373	1286: Down Regulation, GSS and GSTs gene	1287: Glutathione synthesis	Feb 15, 2017	Feb 15, 2017	1 AOP 209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
1376	1286: Down Regulation, GSS and GSTs gene	1290: Glutathione homeostasis	Feb 15, 2017	Feb 15, 2017	1 AOP 209: Perturbation of cholesterol and glutathione homeostasis leading to hepatotoxicity: Integrated multi-OMICS approach for building AOP
524	474: Down Regulation, HMGCS2	477: Decreased, Ketogenesis	Nov 29, 2016	Dec 3, 2016	1 AOP 60: NR1I2 (Pregnane X Receptor, PXR) activation leading to hepatic steatosis
446	427: Down Regulation, K-Cl co-transporter 2 (KCC2)	428: Delay, Developmental GABA shift	Nov 29, 2016	Dec 3, 2016	None
2136	1787: Downregulation of ACE2	1743: Increase plasma Ang II	May 15, 2020	May 15, 2020	None
2137	1787: Downregulation of ACE2	1752: Increased AngII	May 15, 2020	May 15, 2020	1 AOP 381: Binding of viral S-glycoprotein to ACE2 receptor leading to dysgeusia
2517	1787: Downregulation of ACE2	1935: Ang (1-7) levels reduced	Oct 28, 2021	Oct 28, 2021	None
2502	1945: Dysfunctional autophagy	1942: Accumulation, Toxic Tau oligomers	Oct 26, 2021	Oct 26, 2021	1 AOP 429: A cholesterol/glucose dysmetabolism initiated Tau-driven AOP toward memory loss (AO) in sporadic Alzheimer's Disease with plausible MIE's plug-ins for environmental neurotoxicants
2676	1945: Dysfunctional autophagy	2011: Emphysema	Jun 17, 2022	Jun 17, 2022	1 AOP 452: Adverse outcome pathway of PM-induced respiratory toxicity
2006	1703: Cardiovascular dysregulation	445: Respiratory distress/arrest	Nov 25, 2019	Dec 19, 2019	1 AOP 16: Acetylcholinesterase inhibition leading to acute mortality
3223	2224: Dysregulation of transcriptional expression within PPAR signaling network	179: Decrease, Fatty acid β-oxidation	May 14, 2024	May 24, 2024	1 AOP 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
3224	2224: Dysregulation of transcriptional expression within PPAR signaling network	2225: Disrupted Lipid Storage	May 14, 2024	May 29, 2024	1 AOP 529: Xenobiotic binding to peroxisome proliferator-activated receptors (PPARs) causes dysregulation of lipid metabolism leading to liver steatosis
2493	1854: ACE2 dysregulation	1497: Recruitment of inflammatory cells	Oct 19, 2021	Oct 19, 2021	None
2532	1854: ACE2 dysregulation	1954: Gut dysbiosis	Dec 2, 2021	Dec 2, 2021	1 AOP 428: Binding of S-protein to ACE2 in enterocytes induces ACE2 dysregulation leading to gut dysbiosis
2831	1854: ACE2 dysregulation	2096: (Micro)vascular dysfunction	Jan 23, 2023	Feb 28, 2023	1 AOP 385: Viral spike protein interaction with ACE2 leads to microvascular dysfunction, via ACE2 dysregulation
1856	1600: Eczematous eruption	1601: Scaling, Lichenification	Feb 4, 2019	Feb 4, 2019	None
3498	2310: FAM50B/PTCHD3 expression	2311: PI3K-Akt pathway	Mar 2, 2025	Mar 2, 2025	1 AOP 569: Decreased DNA methylation of FAM50B/PTCHD3 leading to IQ loss of children via PI3K-Akt pathway
3650	2363: Mito ROS dysfunction	889: Proteostasis, impaired	Oct 3, 2025	Oct 3, 2025	1 AOP 593: Redox cycling of a chemical by mitochondria leads to degeneration of nigrostriatal dopaminergic neurons
3691	2363: Mito ROS dysfunction	1262: Apoptosis	Nov 7, 2025	Nov 7, 2025	1 AOP 616: organic UV filter and its Photoproducts reproductive toxicity pathways
2680	2011: Emphysema	2008: Chronic obstructive pulmonary disease	Jun 17, 2022	Jun 17, 2022	1 AOP 452: Adverse outcome pathway of PM-induced respiratory toxicity

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