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Showing 3026 to 3050 of 3164 KERs

ID	Upstream Event	Downstream Event	Creation Date	Last Updated	AOPs

1720	1507: Activation of PPARγ	149: Increase, Inflammation	Mar 18, 2018	Mar 18, 2018	None
3697	1507: Activation of PPARγ	202: Inhibition, Nuclear factor kappa B (NF-kB)	Dec 3, 2025	Dec 3, 2025	None
3816	1507: Activation of PPARγ	2441: Increased fatty acid synthesis and transport	Jul 9, 2026	Jul 9, 2026	1 AOP 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
3818	1507: Activation of PPARγ	1824: Decrease, FAO	Jul 9, 2026	Jul 9, 2026	1 AOP 646: Binding and activation of AhR/PPARγ lead to lipid metabolism disorders
2990	2165: Activation of PPAR	2167: Activation of MMP-2 MMP-9	Aug 20, 2023	Aug 20, 2023	1 AOP 510: Demethylation of PPAR promotor leading to vascular disrupting effects
2991	2165: Activation of PPAR	2168: Activation of angiopoietin like protein 4	Aug 20, 2023	Aug 20, 2023	1 AOP 510: Demethylation of PPAR promotor leading to vascular disrupting effects
2992	2165: Activation of PPAR	2169: Activation of Angiogenic cytokines	Aug 20, 2023	Aug 20, 2023	1 AOP 510: Demethylation of PPAR promotor leading to vascular disrupting effects
3278	2165: Activation of PPAR	1392: Increase, Oxidative Stress	Jul 4, 2024	Jul 4, 2024	1 AOP 510: Demethylation of PPAR promotor leading to vascular disrupting effects
1291	1238: Oxidation	1236: Generation of novel epitopes , Antigen presentation	Nov 29, 2016	Dec 3, 2016	None
1292	1238: Oxidation	1215: TRPA1 activation, TRPA1 Receptor	Nov 29, 2016	Dec 3, 2016	None
1293	1238: Oxidation	1234: Production of nerve growth factor , Epithelial irritation	Nov 29, 2016	Dec 3, 2016	None
2994	2167: Activation of MMP-2 MMP-9	1928: increased，Vascular endothelial dysfunction	Aug 20, 2023	Aug 20, 2023	1 AOP 510: Demethylation of PPAR promotor leading to vascular disrupting effects
2942	2146: Activation of MEK, ERK1/2	1339: Increase, intracellular calcium	Jun 20, 2023	Apr 11, 2024	2 AOPs 499: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via disrupted neurotransmitter release 500: Activation of MEK-ERK1/2 leads to deficits in learning and cognition via ROS and apoptosis
2701	2036: Activation, mGLUr	389: Increased, Intracellular Calcium overload	Jul 25, 2022	Jul 25, 2022	None
2703	2036: Activation, mGLUr	2037: Activation, IP3R	Jul 25, 2022	Jul 25, 2022	1 AOP 464: Calcium overload in dopaminergic neurons of the substantia nigra leading to parkinsonian motor deficits
2673	2009: Activation, inflammation pathway	2010: Pulmonary inflammation	Jun 17, 2022	Jun 17, 2022	1 AOP 452: Adverse outcome pathway of PM-induced respiratory toxicity
2981	2009: Activation, inflammation pathway	1928: increased，Vascular endothelial dysfunction	Aug 19, 2023	Aug 19, 2023	2 AOPs 507: Nrf2 inhibition leading to vascular disrupting effects via inflammation pathway 511: The AOP framework on ROS-mediated oxidative stress induced vascular disrupting effects
3006	2009: Activation, inflammation pathway	2175: Endothelial cell death	Aug 21, 2023	Aug 21, 2023	None
3007	2009: Activation, inflammation pathway	2176: Decreased endothelial cell proliferation	Aug 21, 2023	Aug 21, 2023	None
3008	2009: Activation, inflammation pathway	1472: Decrease, ATP production	Aug 21, 2023	Aug 21, 2023	None
3009	2009: Activation, inflammation pathway	2161: Increase, Vascular disrupting effects	Aug 21, 2023	Aug 21, 2023	None
3756	2009: Activation, inflammation pathway	344: Increase, Liver fibrosis	Mar 25, 2026	Mar 25, 2026	1 AOP 638: Co-exposure to microplastics and cadmium leading to progression from NAFLD to liver tumorigenesis
1512	1391: Activation of Cyp2E1	1392: Increase, Oxidative Stress	May 30, 2017	Jul 1, 2021	2 AOPs 220: Cyp2E1 Activation Leading to Liver Cancer 450: Inhibition of AChE and activation of CYP2E1 leading to sensory axonal peripheral neuropathy and mortality
1515	1391: Activation of Cyp2E1	1393: Hepatocytotoxicity	May 30, 2017	Dec 6, 2018	1 AOP 220: Cyp2E1 Activation Leading to Liver Cancer
1610	1448: activation of CEBPA	1028: Activation of specific nuclear receptors, PPAR-gamma activation	Jul 24, 2017	Jul 24, 2017	1 AOP 72: Epigenetic modification of PPARG leading to adipogenesis

Key Event Relationships (KERs)

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